Chemical composition and antinociceptive effect of aqueous extract from Rourea induta Planch. leaves in acute and chronic pain models

Ethnopharmacological and botanical evaluation of medicinal plants used by Brazilian Amazon Indian community

“…Although this effect is not yet scientifically proven, it has been shown that the aqueous extract Rourea induta has analgesic action. related to the inhibition of release of inflammatory mediators (KALEGARI et al, 2014), which may correlate with their healing potential.…”

A review on traditional uses, phytochemistry, and pharmacology of the genus Rourea

“…Treatment of aqueous extract on mice resulted in the significant antinociceptive effect on different pain models without affecting the motor activity and corporal temperature of the mice, and the extract did not depend on the opioid system (Kalegari et al, 2014a).…”

“…induta Planch is commonly known as chapeudinha, pau-de-porco, or campeira and is widely distributed in Brazil. It is traditionally used in folk medicine to treat rheumatisms and Chagas disease (Kalegari et al, 2014a). R. cuspidate Benth ex.…”

Phytotherapeutical implications in pain perception - focusing on schizophrenia

“…Besides the studies mentioned above, there are a lot others that approve of the traditional medical practices, arguing their perspectives through testing the effects of the plants used. It is worth reminding here the researches made on the antinociceptive effects of plant extracts such as Phyllanthus fraternus family Euphorbiaceae, with proven action on chronic pain induced in mice showing a potential worth mentioning in managing persistent pain [58]; Rourea induta Planch family Connaraceae -aqueous extract from leaves -proven high effectiveness in antinociceptive action, approving of previous phytotherapeutic use [59]; Pistacia integerrima family Anacardiaceae -the pistagremic acid isolated from this plant shows a strong peripheral as well as central antinociceptive activity, presenting also antiinflammatory and antipyretic qualities [60]; Xeromohis nilotica family Rubiaceaeaqueous extract from root bark -has a short antiinflammatory quality and an antinociceptive effect [61]; Impatiens balsamina family Balsaminaceae -flower methanol extract -central and peripheral antinociceptive proprieties are reported [62]; Geoffroea decorticans family Febaceae -aqueous extract from fruits and syrup-own significant antinociceptive effects [63]; Remirea maritime family Cyperaceae -aqueous extract from this plant indicates analgesic proprieties in different experimental pain models, leading to the assumption that they manifest due to the inhibition of peripheral mediators which could be related to the powerful antioxidant effects noticed in vitro [64]. All of the above are sustaining custom plant treatment.…”

“…Aqueous extract from leavesantinociceptive actions [59] leaf ethanolic extract -in vitro antioxidant activity associated to in vivo hepatoprotective potential [131,132,133] treatment of rheumatisms and Chagas disease [134] Solanum kwebense (Solanaceae) --cerebellar cortical substance degeneration, involving selectively Purkinje neurons [65] abdominal pain, inflammation and rheumatism [32] Xeromohis nilotica (Rubiaceae) aqueous extract from root bark -antinociceptive effect [61] aqueous extract from root bark-short antiinflammatory quality [61]; rootbark extracts -sedative activities [135,136]; antischistosomal [137], molluscidal [138] activities pain, fever, epilepsy and mental disorder [139,140] Consequently, if we take into consideration that synergism between cannabinoids and opioids modulates performance in the fight against pain by targeting multiple pain mechanisms and also the aforementioned antipsychotic and antinociceptive proprieties of cannabidiol and the involvement of opioid mechanisms in pain and schizophrenia, we might be looking at the beginning of a new era in the treatment of pain, but also in the battle against schizophrenia, this complex severe mental illness with modified perception of pain.…”