Chemical composition and antimicrobial, antioxidant activities and anti-inflammatory potential of Achillea millefolium L., Anethum graveolens L., and Carum copticum L. essential oils

Kazemi, Mohsen

doi:10.1016/j.hermed.2015.09.001

Cited by 46 publications

(32 citation statements)

References 28 publications

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“…Moreover, DPPH, MCA and RP exhibited a positive linear correlation (r=0.608** for DPPH and MCA, r=0.720* for DPPH and RP, and r=0.642* for MCA and RP values). Principal component analysis and correlation coefficients exhibited that flavonoid and phenolic compounds are responsible for the antioxidant activity in extracts of A. gypsicola , important correlations of antioxidant activities and polyphenols have been reported in different previous studies about Achillea species . Our results are in agreement with previous data in terms of correlations among flavonoid, phenolic compounds, DPPH, RP and MCA assays in Achillea species.…”

Section: Resultssupporting

confidence: 92%

“…Our results showed that the free radical scavenging capacity of the plants harvested in full flowering stage was higher than many Achillea species in previous study. It was determined that some Achillea species showed stronger antioxidant activity than positive controls also at previous studies by researchers, as in our study . Antioxidant activity can be varied in different organs and phenological stages of the same species.…”

Section: Resultssupporting

confidence: 75%

“…There are many reports about the antimicrobial activity of the volatile oils of Achillea species . Kazemi reported that volatile oil of A. millefolium showed higher antimicrobial activity than the control antibiotics against all fungal and bacterial organisms tested ( C. albicans , A. fumigatus , B. cereus , E. faecalis , S. aureus , E. coli , P. aeruginosa , P. mirabilis , S. typhimurium and C. freundii ).…”

Section: Resultsmentioning

confidence: 99%

“…In another study, Afshari and Rahimmalek reported that the highest antioxidant activity of A. aucheri species was determined at the 50 % flowering stage, while the lowest activity was obtained at 5‐leaf stage. So far, many studies have shown that the phenolic compounds (phenolic acids and flavonoids) of Achillea species are correlated with antioxidant activity . Therefore, determination of the composition of phenolic compounds in their phenological stages can be important for the antioxidant activity.…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of Phytochemical Compositions and Biological Properties of Achillea gypsicola at Different Phenological Stages

Açıkgöz

2019

Chemistry & Biodiversity

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Phytochemicals, which are commonly found at different levels in many medicinal plants, are natural strong antioxidants used in traditional medicine. In this research, determination of differences of phytochemical compositions and biological properties were aimed as periodically (pre-, full and post flowering) and daily (6 am, 1 pm and 8 pm) in Achillea gypsicola HUB.-MOR. The volatile oils belonging to A. gypsicola were obtained by hydrodistillation and analyzed by gas chromatography-flame ionization detection (GC-FID) and gas chromatography-mass spectrometry (GC/MS). The antimicrobial activities of the volatile oils were determined with disc diffusion method. The microdilution method was used to determine minimum inhibitory concentration (MIC). Total phenolic and flavonoid contents were determined by spectrophotometric methods and antioxidant capacities were evaluated by 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical, reducing power (RP) and metal chelating activity (MCA) assay. In addition, the phenolic acid and flavonoid compositions were evaluated by reversed phase-high-performance liquid chromatography (RP-HPLC). This study presented a comprehensive report for the first time on evaluation of the phytochemical composition and the biological properties of A. gypsicola at different phenological stages. Thirty-two compounds, containing the major component as camphor, 1,8-cineole and borneol, were detected. Designated harvest time for the highest yield of volatile oils was found to be at full flowering stage-1 pm. It has been observed that the volatile oil composition changes periodically and even daily. Also, in this research, menthol and menthone were found as the composition of volatile oil in Achillea species for the first time. Full flowering stage was found as the richest period in terms of phenolic acid and flavonoid compositions of A. gypsicola for the first time. The species examined in this research showed a high antioxidant and antimicrobial activity in comparison to other studies with Achillea species. The volatile oils exhibited high performances with range of inhibition zones (8.3-42.3 mm) and minimum inhibitory concentration values (2.25-144 μg/ml). Besides, a high correlation between antioxidant activity and phenolic content of A. gypsicola was found. These results suggest that A. gypsicola can be used as a safe source in the cosmetic, food and pharmaceutical industries.

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Section: Resultssupporting

confidence: 92%

Section: Resultssupporting

confidence: 75%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Evaluation of Phytochemical Compositions and Biological Properties of Achillea gypsicola at Different Phenological Stages

Açıkgöz

2019

Chemistry & Biodiversity

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“…Recently, many natural medicines, which have fewer side effects and offer the possibility of long-term use, have been evaluated to determine their antibacterial and anti-inflammatory potential [34][35][36][37][38]. Included among these is a large group of perennial plants in the Polygonaceae, which are used in East Asian medicine to promote blood circulation, relieve pain, treat diuretic and menstrual disorders, and alleviate respiratory problems.…”

Section: Introductionmentioning

confidence: 99%

Biocompatibility and Antimicrobial Activity of Reynoutria elliptica Extract for Dental Application

Yang

Kang

2020

Plants

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This study was conducted to determine whether nature-derived Reynoutria elliptica extracts exhibit biocompatibility and antimicrobial effects against oral pathogens such as Streptococcus mutans and Candida albicans. Fine particles of Reynoutria elliptica extract were used to probe for biocompatibility and antimicrobial activity toward these pathogens, and results were evaluated with an MTT (3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide) assay, spectrophotometric growth inhibitory assay, the total number of colony-forming units (CFU), an agar disk diffusion test, and scanning electron microscopy (SEM). In addition, UV/VIS spectroscopy was used to determine the levels of flavonoid and polyphenol in experimental solutions. Several experimental groups showed cell viability higher than 70%, and the antimicrobial activity toward both S. mutans and C. albicans was significantly higher than was that seen for the control group. In CFU and agar disk diffusion tests with C. albicans, increases in the concentration of Reynoutria elliptica extract led to significantly increased antimicrobial effects. Additionally, SEM results showed that Reynoutria elliptica extract changed the morphology and density of S. mutans and C. albicans. The results of this research can be applied to the use of Reynoutria elliptica extracts for the development of oral products that are biologically friendly and can control oral diseases such as dental caries and candida-associated denture stomatitis.

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Essential Oils of Six Achillea Species: Chemical Profiles, Antimicrobial Potential and Toxicity toward Crustaceans

Stojanović

Stojanović-Radić

et al. 2022

Chemistry & Biodiversity

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This is the first comparative study on antimicrobial activity of essential oils (EOs) of six Achillea species (A. crithmifolia, A. distans, A. grandifolia, A. millefolium, A. nobilis, and A. lingulata) against ATCC and clinical microbial strains isolated from human swabs and on their toxicological potential on crustaceans. Oxygenated monoterpenes represented the major compound class in all six EOs, ranging from around 50 % (A. millefolium, A. nobilis, and A. lingulata) up to over 80 % (A. crithmifolia and A. grandifolia). Specific phytochemical profiles of the major volatiles were determined for each species. Still, borneol was the dominant compound in EOs of three yarrow species: A. distans, A. lingulata, and A. millefolium. Other major compounds were 1,8-cineole in A. crithmifolia, camphor in A. grandifolia, and artemisia ketone in A. nobilis EO. Antimicrobial activities of EOs were examined by a microdilution method revealing inhibitory action against all 15 studied strains in the range of 0.07 -20.00 mg/mL (MICs). High toxicity (LC 50 < 100 μg/mL) in Artemia salina acute toxicity bioassay was a shared characteristic, appearing in five out of six tested EOs, i. e., those isolated from A. lingulata, A. millefolium, A. distans, A. nobilis, and A. grandifolia. In both types of biological tests, A. lingulata EO has shown the highest and A. crithmifolia EO the lowest potential. The strongest activities, recorded for EO of A. lingulata, which was the only studied species from the section Anthemoideae, may be explained by its somewhat unusual chemical composition. According to the obtained results, the second dominant compound of this EO is γ-palmitolactone, which may be a significant agent regarding the antimicrobial activity and toxicity to crustaceans, either on its own or in union with other components, and it may be a suitable topic for further research.

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Chemical composition and antimicrobial, antioxidant activities and anti-inflammatory potential of Achillea millefolium L., Anethum graveolens L., and Carum copticum L. essential oils

Cited by 46 publications

References 28 publications

Evaluation of Phytochemical Compositions and Biological Properties of Achillea gypsicola at Different Phenological Stages

Evaluation of Phytochemical Compositions and Biological Properties of Achillea gypsicola at Different Phenological Stages

Biocompatibility and Antimicrobial Activity of Reynoutria elliptica Extract for Dental Application

Essential Oils of Six Achillea Species: Chemical Profiles, Antimicrobial Potential and Toxicity toward Crustaceans

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