Chemical composition and anticancer activity of essential oils of Mediterranean sage (Salvia officinalis L.) grown in different environmental conditions

Russo, Alessandra; Formisano, Carmen; Rigano, Daniela; Senatore, Felice; Delfine, Sebastiano; Cardile, Venera; Rosselli, Sergio; Bruno, Maurizio

doi:10.1016/j.fct.2012.12.036

Cited by 191 publications

(124 citation statements)

References 30 publications

(33 reference statements)

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“…Polyphenol compounds are commonly found in sage, however, crude extracts will present different concentrations of polyphenols depending on several conditions like extraction method, plant geographic origin and harvest season (Russo et al 2013).…”

Section: Discussionmentioning

confidence: 99%

Pharmacological perspectives from Brazilian Salvia officinalis (Lamiaceae): antioxidant, and antitumor in mammalian cells

Garcia

Menti

Lambert

et al. 2016

An. Acad. Bras. Ciênc.

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Salvia offi cinalis (Lamiaceae) has been used in south of Brazil as a diary homemade, in food condiment and tea-beverage used for the treatment of several disorders. The objective of this study was to characterize chemical compounds in the hydroalcoholic (ExtHS) and aqueous (ExtAS) extract from Salvia offi cinalis (L.) by gas chromatography-mass spectrometry (GC-MS) and by high-resolution electrospray ionization mass spectrometry (ESI-QTOF MS/MS), evaluate in vitro ability to scavenge the free radical 2,2-diphenyl-1-picrylhydrazyl (DPPH • ) and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS •+ ), catalase (CAT-like) and superoxide dismutase (SOD-like) activity, moreover cytotoxic by MTT assay, alterations on cell morphology by giemsa and apoptotic-induced mechanism for annexin V/propidium iodide. Chemical identifi cation sage extracts revealed the presence of acids and phenolic compounds. In vitro antioxidant analysis for both extracts indicated promising activities. The cytotoxic assays using tumor (Hep-2, HeLa, A-549, HT-29 and A-375) and in non-tumor (HEK-293 and MRC-5), showed selectivity for tumor cell lines. Immunocytochemistry presenting a majority of tumor cells at late stages of the apoptotic process and necrosis. Given the results presented here, Brazilian Salvia offi cinalis (L.) used as condiment and tea, may protect the body against some disease, in particularly those where oxidative stress is involved, like neurodegenerative disorders, infl ammation and cancer.

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Section: Discussionmentioning

confidence: 99%

Pharmacological perspectives from Brazilian Salvia officinalis (Lamiaceae): antioxidant, and antitumor in mammalian cells

Garcia

Menti

Lambert

et al. 2016

An. Acad. Bras. Ciênc.

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show abstract

“…SO has a wide range of constituents include alkaloids, carbohydrate, fatty acids, glycosidic derivatives (e.g., cardiac glycosides, flavonoid glycosides, saponins), poly acetylenes, steroids and waxes [8,9].…”

Section: Biochemical Contents and Phytochemistrymentioning

confidence: 99%

Recent Studies on the Neuropharmacological Effects of Salvia officinalis L.: A Promising Candidate for Alzheimer's Disease

Hasanein¹,

Sharifi²,

Emamjomeh³

2017

Med chem

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Salvia is the largest genus of the Lamiaceae family including about 100 species. Salvia officinalis L. (SO) is one of the most appreciated herbs for richness of the essential oil content and its numerous biologically active compounds. SO has been used in herbal medicine for many centuries. In Islamic literature, it is considered as one of the greatest forms of healing medicine. The leaves of the plant have a wide range of biological activities, such as anti-bacterial, fungistatic, virustatic, anticancer, astringent, eupeptic and antihydrotic effects. Recently, this plant has been focused for its application in traditional medicine as well as to find new neurobiological properties. In this review, the up-todate information on the neurobiological effects of SO on the central nervous system will be reviewed. These include analgesic, memory enhancing, neuroprotective, anticonvulsant, anti-addictive, sedative, anxiolytic, and skeletal muscle relaxant effects. Furthermore, chemical compounds responsible for these effects and the clinical studies on this plant are presented and discussed.

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“…The essential oil of S. rubifolia was significantly more effective than the essential oil of S. bracteata that maybe resulted from the difference in the concentration of sesquiterpenes. 112 Russo et al 24 have shown that essential oil of S. officinalis caused the inhibition of cell growth and induction of apoptosis cell death when treated on human melanoma cell lines (A375, M14, and A2058). Because of the influence of environmental and pedoclimatic conditions on the qualitative chemical composition of essential oil, there is difference in the anticancer activity among the essential oils of S. officinalis collected from different places.…”

Section: Other Type Of Cancersmentioning

confidence: 99%

“…Salvia officinalis ( Figure 1C), another important sage widely used in Europe for both culinary and medicinal preparations, 21,22 is reported to have the highest amount of essential oil in leaves compared to the other species of Salvia, which exhibits potent antioxidant capacity, as well as anticancer, antispasmodic, antimicrobial, anti-inflammatory, and carminative and mucolytic activities. 18,19,23,24 Many other species of the genus Salvia have also been studied for their composition and most of the phytochemicals are with potential anticancer properties ( Table 1). In recent years, the potential use of Salvia as a new anticancer agent has been recognized.…”

Section: Introductionmentioning

confidence: 99%

The anticancer properties of phytochemical extracts from Salvia plants

Jiang¹,

Zhang²,

Rupasinghe³

2016

BTAT

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Chemical composition and anticancer activity of essential oils of Mediterranean sage (Salvia officinalis L.) grown in different environmental conditions

Cited by 191 publications

References 30 publications

Pharmacological perspectives from Brazilian Salvia officinalis (Lamiaceae): antioxidant, and antitumor in mammalian cells

Pharmacological perspectives from Brazilian Salvia officinalis (Lamiaceae): antioxidant, and antitumor in mammalian cells

Recent Studies on the Neuropharmacological Effects of Salvia officinalis L.: A Promising Candidate for Alzheimer's Disease

The anticancer properties of phytochemical extracts from Salvia plants

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