Chemical Composition and Antibacterial Activity of the Essential Oil of <i>Espeletia nana</i>

Peña, Aránzazu; Rojas, Luis; Aparicio, Rosa; Alarcón, Libia; Baptista, José Gregorio; Velasco, Judith; Carmona, Juan; Usubillaga, Alfredo

doi:10.1177/1934578x1200700530

Cited by 10 publications

(11 citation statements)

References 13 publications

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“…These substances exert their toxic effect against some microorganisms through disruption of their membrane integrity, inhibiting respiration and ion transport processes [5c] . There are no previous reports on either the chemical composition or antimicrobial activity of the essential oil of R. Bracteosa, but similar antimicrobial activity against Gram-positive bacteria was reported by Peña et al [6] for the essential oil of Espeletia nana. The most abundant compounds of E. nana oil were α-pinene (38.1%), β-pinene (17.2%), and myrcene (15.0%).…”

supporting

confidence: 56%

Chemical Composition and Antibacterial Activity of the Essential Oil of Ruilopezia bracteosa

Alarcón

Peña

Velascd

et al. 2015

Natural Product Communications

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The essential oil from the leaves of Ruilopezia bracteosa was obtained by hydrodistillation, and analyzed by GC-MS. Eighteen components, which made up 99.6% of the oil were identified, the most abundant being β-myrcene (34.2%), α-pinene (24.3%), 7-epi--selinene (9.1%), β-pinene (8.5%) and 6,9-guaiadiene (4.4%). Antibacterial activity was tested against Gram-positive and Gram-negative bacteria using broth microdilution and disk agar diffusion methods. MIC values found presented significant differences between both methods, which may be due to diffusion factors.

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supporting

confidence: 56%

Chemical Composition and Antibacterial Activity of the Essential Oil of Ruilopezia bracteosa

Alarcón

Peña

Velascd

et al. 2015

Natural Product Communications

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“…It can contribute up to 30% of the essential oils in ginger rhizomes. 24 ZBN has several pharmacological properties such as antioxidant, 25 anticancer, 26 antiulcer, 27 antibacterial, 28 and antiviral 29 effect. ZBN possess the ability to modulate the inflammatory PI3K/AKT/mTOR pathway in human cells.…”

Section: Introductionmentioning

confidence: 99%

Anti-inflammatory and anti-apoptotic effect of zingiberene on isoproterenol-induced myocardial infarction in experimental animals

Li¹,

Radhiga

Kanimozhi

et al. 2020

Hum Exp Toxicol

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This study aimed to investigate the antihyperlipidemic and anti-inflammatory effect of zingiberene (ZBN) on isoproterenol-(ISO) induced myocardial infarction in rats. ZBN (10 mg/kg b.wt.) was orally administered to rats for 21 days and ISO (85 mg/kg b.wt.) was subcutaneously injected into the rats at 24 h intervals for the last 2 consecutive days. We observed increased serum creatine kinase, creatine kinase-MB, cardiac troponin T, and I levels in ISO-treated MI rats. Conversely, ZBN oral administration significantly prevented in cardiac marker enzyme activities in ISO-mediated rats. We also noticed that ZBN oral administration prevented ISO-induced expression of lipid peroxidative markers, total cholesterol, triglycerides, phospholipids, free fatty acids, very-low-density lipoprotein cholesterol (VLDL-C), low-density lipoprotein cholesterol (LDL-C) to the normal basal level. Furthermore, ZBN restored ISO-mediated antioxidant status, increased level of high-density lipoprotein cholesterol (HDL-C), and tissue phospholipids to the near-normal levels. Besides, ZBN pre-treatment significantly reduced the level of inflammatory markers (TNF-α, IL-6, NF-κB, and IL-1β) in ISO-induced MI in rats. We noticed that ZBN pretreatment inhibited the pro-apoptotic proteins Bax and cytochrome c and increased the Bcl-2 expression in ISO induced rats. The gene expression profiling by qRT-PCR array illustrates that ZBN treatment prevents the ISO mediated activation of cardiac markers, inflammatory, and fibrosis-related genes in the heart tissue. Taken together, pre-treatment with ZBN attenuated ISO-induced MI resolved exhibits the anti-inflammatory and antiapoptotic effect.

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“…It can contribute up to 30% of the essential oils in ginger rhizomes. 21 The limited numbers of recent investigations have revealed that ZGB exhibits many important biological activities, including antioxidant activity, 22 anticarcinogenic activity, 23 antiulcer activity, 24 antibacterial activity 25 and antiviral activity. 26 However, whether ZGB exerts protective effects against oxidative cytotoxicity in neuronal models as a result of its antioxidant property has not been investigated.…”

Section: Introductionmentioning

confidence: 99%

Zingiberene attenuates hydrogen peroxide-induced toxicity in neuronal cells

et al. 2014

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In this experimental design, we explored the neuroprotective potential of zingiberene (ZGB), a monocyclic sesquiterpene, in hydrogen peroxide (H2O2)-induced toxicity in newborn rat cerebral cortex cell cultures for the first time. The rats were exposed to H2O2 for 6 h to determine the oxidative stress levels. To evaluate cell viability, both 3-(4,5-dimethylthiazole-2-yl)-2,5-diphenyltetrazolium bromide and lactate dehydrogenase assays were carried out. Total antioxidant capacity (TAC) and total oxidative stress (TOS) parameters were used to evaluate oxidative changes. Besides determining 8-hydroxy-2-deoxyguanosine (8-OH-dG) levels in vitro, single-cell gel electrophoresis was also performed to measure the resistance of neuronal DNA to H2O2- exposed rats. Our results showed that survival and TAC levels of the cells decreased, while TOS, 8-OH-dG levels and the mean values of the total scores of cells showing DNA damage increased in the H2O2 alone-treated cultures. But pretreatment of ZGB suppressed the cytotoxicity, genotoxicity and oxidative stress that were increased by H2O2. Based on these observations, it is suggested that the sesquiterpene ZGB can be used as a novel and natural potential therapeutic in counteracting oxidative damages in the field of neurodegenerative disorders.

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Chemical Composition and Antibacterial Activity of the Essential Oil of Espeletia nana

Cited by 10 publications

References 13 publications

Chemical Composition and Antibacterial Activity of the Essential Oil of Ruilopezia bracteosa

Chemical Composition and Antibacterial Activity of the Essential Oil of Ruilopezia bracteosa

Anti-inflammatory and anti-apoptotic effect of zingiberene on isoproterenol-induced myocardial infarction in experimental animals

Zingiberene attenuates hydrogen peroxide-induced toxicity in neuronal cells

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