Chemical Composition and Antibacterial Activity of the Essential Oil of <i>Spirulina platensis</i> from Morocco

Bellahcen, Touria Ould; Cherki, M.; Cayuela, José Antonio; Cherif, Abdelmjid; Elamrani, Abdelaziz

doi:10.1080/0972060x.2019.1669492

Cited by 16 publications

(30 citation statements)

References 32 publications

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“…Overall, we may infer that the antibacterial outcomes of CFTD and BFTD against selected strains were dose-dependent. Some compounds identified in the CFTD and BFTD by GC-MS comprise antibacterial activity like ethylbenzene [50], tetradecane [51], benzene [52], pentadecanoic acid [53], heneicosane [54], octadec-9-enoic acid [55], and 3H-1,2,4-triazole-3-thione [56] which confirms the results of antibacterial T. domingensis. As the T. domingensis has been used traditionally as antiwound activity, it would be a good edition in the pharmaceutical field [57].…”

Section: Discussionsupporting

confidence: 54%

Chemical Composition and Biological Evaluation of Typha domingensis Pers. to Ameliorate Health Pathologies: In Vitro and In Silico Approaches

Dilshad

Khan

Saeed

et al. 2022

BioMed Research International

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Human diseases are becoming more prevalent, necessitating the development of modalities to overcome the challenges of treating various disorders. In the current research, we analyzed the biomedicinal role of Typha domingensis which is an important medicinal plant. The species is traditionally used in the treatment of neurological disorders and skin malignancies. The chloroform (CFTD) and n-butanol fractions of T. domingensis (BFTD) were subjected to chemical profiling through the determination of total polyphenolic contents and GC-MS analysis. The oral toxicity test was applied to investigate the toxicity of the extracts. Antioxidant capacity was analyzed by four in vitro methods: DPPH, ABTS, FRAP, and CUPRAC. The pharmacological potential was evaluated through clinically significant enzyme inhibition assays, thrombolytic, and antimicrobial activities. In silico molecular docking approach was applied to confirm the role of T. domingensis against the enzymes. The polyphenolic quantification revealed that the BFTD was comparatively rich in total phenolic and flavonoid contents (97.14 milligrams gallic acid equivalent (mg GAE/g) and 362.5 milligrams quercetin equivalent per gram of dry extract (mg QE/g DE), respectively), as compared to the CFTD. The GC-MS analysis of the CFTD and BFTD resulted in the tentative identification of 67 and 29 compounds, respectively, with the major components of fatty acids and essential oil. The oral toxicity test revealed the safety and biocompatibility of CFTD and BFTD. Both the fractions showed promising antioxidant activity. Tyrosinase was found as the major enzyme inhibited by BFTD (78.67%) and CFTD (68.09%), whereas the standard kojic acid showed 85.58% inhibition. The inhibition results of acetylcholinesterase and butyrylcholinesterase by BFTD (71.65 and 60.79%, respectively) are higher than CFTD. Both the fractions were found active against various strains of bacteria. Furthermore, the molecular docking studies of the compounds showed a good docking score against all the docked enzymes among which deoxycaesaldekarin C was found with the highest binding affinities in comparison to the standard. The current study suggests that T. domingensis is nontoxic and can be a potential source of phytoconstituents with promising pharmacological potential.

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Section: Discussionsupporting

confidence: 54%

Chemical Composition and Biological Evaluation of Typha domingensis Pers. to Ameliorate Health Pathologies: In Vitro and In Silico Approaches

Dilshad

Khan

Saeed

et al. 2022

BioMed Research International

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“…On the other hand, it has been reported that 2-heptanone, 6-methyl-5-heptene-2-one, and 2-undecanone ketones, produced by Pseudoalteromonas sp. GA327, present antibacterial properties against pathogenic Gram-positive and Gram-negative bacteria [ 31 , 32 , 33 , 34 , 35 ]. Regarding the inhibitory activity of the volatile ester butyl formate, one of the VOCs detected in higher amounts in Pseudoalteromonas sp.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Antibacterial Activity of Volatile Organic Compounds Produced by the Octocoral-Associated Bacteria Bacillus sp. BO53 and Pseudoalteromonas sp. GA327

et al. 2020

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The present research aimed to evaluate the antibacterial activity of volatile organic compounds (VOCs) produced by octocoral-associated bacteria Bacillus sp. BO53 and Pseudoalteromonas sp. GA327. The volatilome bioactivity of both bacteria species was evaluated against human pathogenic antibiotic-resistant bacteria, methicillin-resistant Staphylococcus aureus, Acinetobacter baumanni, and Pseudomonas aeruginosa. In this regard, the in vitro tests showed that Bacillus sp. BO53 VOCs inhibited the growth of P. aeruginosa and reduced the growth of S. aureus and A. baumanni. Furthermore, Pseudoalteromonas sp. GA327 strongly inhibited the growth of A. baumanni, and P. aeruginosa. VOCs were analyzed by headspace solid-phase microextraction (HS-SPME) joined to gas chromatography-mass spectrometry (GC-MS) methodology. Nineteen VOCs were identified, where 5-acetyl-2-methylpyridine, 2-butanone, and 2-nonanone were the major compounds identified on Bacillus sp. BO53 VOCs; while 1-pentanol, 2-butanone, and butyl formate were the primary volatile compounds detected in Pseudoalteromonas sp. GA327. We proposed that the observed bioactivity is mainly due to the efficient inhibitory biochemical mechanisms of alcohols and ketones upon antibiotic-resistant bacteria. This is the first report which describes the antibacterial activity of VOCs emitted by octocoral-associated bacteria.

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“…Antibacterial compounds in leaves extract were γ-Muurolene (Perigo et al 2016), 1-Tricosene (Susilo et al 2022), 2,4-Di-tert-butylphenol, 4-Di-tert-butylphenol (Aissaoui et al 2018) 9-Eicosene, (Lulamba et al 21021), α-Pinene (Rivas da Silva et al 2012;Dhar et al 2014). Cyclohexene, 4-methylene-1-(1 methylethyl)-or β-Terpinene (Guimarães et al 2019), Cyclopentaneacetic acid, 3-oxo-2-pentyl-, methyl ester (Shannon and Abu-Ghannam 2016), D-Limonene (Costa et al 2019;Han et al 2020), Ethylbenzene (Bellahcen et al 2019), Heptadecane, 8-methyl- (Ashraf et al 2018), Heptadecanoic acid, methyl ester (Mohadjerani et al 2016), Hexanedioic acid, bis(2-ethylhexyl) ester (alkane); Hexatriacontane (alkane) (Afzal et al 2014), Isopropyl myristate (Cardoso et al 2006), Methyl stearate (fatty acid methyl ester) (Agoramoorthy et al 2007), Nonadecane (Wijayanti and Dewi 2022), Oxalic acid, allyl hexadecyl ester (Dicarboxylic acid) (Zayed and Samling 2016), o-Xylene (Nimbeshaho et al 2020), Pentadecanoic acid, 14methyl-, methyl ester (Fatty-acid) (Yoon et al 2018), p-Xylene (Nimbeshaho et al 2020), Tetratetracontane (Agarwal et al 2017, Jamil et al 2021), and Tritetracontane (Martins et al 2015. While antibacterial compounds in rhizome were 1HCyclopenta [1,3] [3aS (3a.alpha., 3b.beta., 4.beta.,7.alpha., 7aS) or β-Cubebene (Constant et al 2019);1H-Cycloprop[e]azulen-7-ol, decahydro-1,1,7-trimethyl-4-methylene-, [1ar-(1a.alpha., 4a.alpha.,7.beta.,7a.beta.,7b.alpha.…”

Section: Phytochemical Profile Analysis Of N-hexane Extracts Of Etlin...mentioning

confidence: 99%

“…While antibacterial compounds in rhizome were 1HCyclopenta [1,3] [3aS (3a.alpha., 3b.beta., 4.beta.,7.alpha., 7aS) or β-Cubebene (Constant et al 2019);1H-Cycloprop[e]azulen-7-ol, decahydro-1,1,7-trimethyl-4-methylene-, [1ar-(1a.alpha., 4a.alpha.,7.beta.,7a.beta.,7b.alpha. ) or spatulenol) (Cazella et al 2019); 1-Hexadecanol (fatty acid) (Togashi et al 2007), 5-Octadecene, (E)- (Naragani et al 2016), 9-Hexadecenoic acid, methyl ester, (Z)- (Rahman et al 2014), α -Pinene (Rivas da Silva et al 2012Dhar et al 2014), Bicyclo[3.1.0]hexane, 4methylene-1-(1-methylethyl)-or sabibine (Utegenova et al 2018), Camphene (de Freitas et al 2020, Copaene (Martins et al 2015, Cyclohexanol, 1-methyl-4-(1-methylethenyl)-, cis-or β-Terpinene (Guimarães et al 2019), Cyclopentaneacetic acid, 3-oxo-2-pentyl-, methyl ester (Shannon and Abu-Ghannam 2016), Decane (Kawuri and Darmayasa 2019), D-Limonene (Costa et al 2019;Han et al 2020), E-15-Heptadecenal (Supardy et al 2012), Ethylbenzene (Bellahcen et al 2019), Eucalyptol (Ghomi and Ahd 2010), γ -Terpinene (Guimarães et al 2019), Heptadecane, 8-methyl-(Ashraf et al 2018, Heptadecanoic acid, methyl ester (Köse et al 2016), Hexadecanoic acid, ethyl ester (Ghareeb et al 2022), Hexadecanoic acid, methyl ester (Ghareeb et al 2022), Isopropyl myristate (Cardoso et al 2006), Nonane (Kawuri and Darmayasa 2019), o-Xylene (Zayed and Samling 2016), Terpinen-4-ol (Cordeiro et al 2020, Tetradecane (Naragani et al 2016, Tridecanoic acid, 12-methyl-...…”

Section: Phytochemical Profile Analysis Of N-hexane Extracts Of Etlin...mentioning

confidence: 99%

Antibacterial and phytochemical constituent of Etlingera rubroloba A.D. Poulsen extract, an endemic ginger from Wallacea Region, Indonesia

ANDILA

NUGROHO²

2022

Biodiversitas

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Abstract. Andila PS, Nugroho LH. 2022. Antibacterial and phytochemical constituent of Etlingera rubroloba A.D. Poulsen extract, an endemic ginger from Wallacea Region, Indonesia. Biodiversitas 23: 3646-3658. Etlingera rubroloba (Blume) AD Poulsen is one of the wild species of the Zingiberaceae which is a native and endemic species in the Wallacea region and has not been studied well for its biology and phytochemical potential. This study aimed to investigate the potential antibacterial activity of hexane extract from the leaves and rhizome of E. rubroloba and study their phytochemical content. The antibacterial activity test was carried out by the agar disc diffusion method against several human pathogenic bacteria and be measured for the Minimum Inhibitory Concentration (MIC) and Zone of inhibition. The phytochemical profile was tested for total phenol content (TPC), total flavonoid content (TFC) and GC-MS analysis. The study results show that TPC of E. rubroloba extracts respectively 15.68±0.80 mg Gallic Acid Equivalent (GAE)/g sample (leaves) and 11.89±0.76 mg GAE/g sample (rhizomes), while TFC value were 33.99±2.24 mg Quercetin Equivalent (QE)/g sample (leaves) and 32.46±0.67 mg QE/g sample (rhizomes). The antibacterial test revealed that E. rubroloba extracts were effective against Bacillus cereus ATCC11778 (with MIC value 0.5 mg/mL using leaves extract and 1 mg/mL in rhizomes), but it was not effective against Escherichia coli ATCC 25922, Staphylococcus aureus ATCC 25923 and Staphylococcus epidermidis ATCC12228. The hexane extracts of E. rubroloba contained a total of 28 and 58 compounds were identified in the leaf extract and rhizome, respectively. The dominant compounds in the leaf extract (Pentadecanoic acid, 14-methyl-, methyl ester; Methyl stearate) and in the rhizome extract (Hexadecanoic acid, ethyl ester; Isopropyl myristate; 9-Octadecenoic acid (Z)-, methyl ester; 9,12- Octadecadienoic acid, methyl ester, (E,E)-) is well known to have antibacterial activity. Based on the results of the antibacterial and phytochemical studies, it can be suggested that E. rubroloba has the potential as an antibacterial agent.

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Chemical Composition and Antibacterial Activity of the Essential Oil of Spirulina platensis from Morocco

Cited by 16 publications

References 32 publications

Chemical Composition and Biological Evaluation of Typha domingensis Pers. to Ameliorate Health Pathologies: In Vitro and In Silico Approaches

Chemical Composition and Biological Evaluation of Typha domingensis Pers. to Ameliorate Health Pathologies: In Vitro and In Silico Approaches

Antibacterial Activity of Volatile Organic Compounds Produced by the Octocoral-Associated Bacteria Bacillus sp. BO53 and Pseudoalteromonas sp. GA327

Antibacterial and phytochemical constituent of Etlingera rubroloba A.D. Poulsen extract, an endemic ginger from Wallacea Region, Indonesia

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