Chemical composition and antibacterial activity of <i>Berberis vulgaris</i> (<i>barberry</i>) against bacteria associated with caries

Kazemipoor, Maryam; Tehrani, Pooya Fadaei; Zandi, Hengameh; Yazdi, Reza Golvardi

doi:10.1002/cre2.379

Cited by 11 publications

(6 citation statements)

References 37 publications

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“…For chitosan decoded with CuO/TiO 2 , the CH 2 bending vibration was observed at 1449 cm −1 [ 35 ]. The peak C-O stretching of the berbamine characteristics was measured at 1060 cm −1 [ 32 ]. Cu-Ti-O has a metal-oxygen stretching vibration of 707, 587, and 528 cm −1 [ 36 ].…”

Section: Resultsmentioning

confidence: 99%

“…The antibacterial potential of a Berberis vulgaris plant extract against microorganisms linked with caries, such as Streptococcus spp. and Lactobacillus rhamnosus, was determined in several in vitro studies [ 32 ]. These nanoparticles and phytocompounds are powerful antibacterial and anticancer agents on their own; however, combining them with the natural polymer chitosan could result in a new hybrid treatment strategy that delivers better results and overcomes individual flaws.…”

Section: Introductionmentioning

confidence: 99%

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[Retracted] CuO‐TiO2‐Chitosan‐Berbamine Nanocomposites Induce Apoptosis through the Mitochondrial Pathway with the Expression of P53, BAX, and BCL‐2 in the Human K562 Cancer Cell Line

Elderdery

Alzahrani

Hamza

et al. 2022

Bioinorganic Chemistry and Applications

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In this study, cells from human Chronic Myelogenous Leukemia (K562) were cultivated with CuO-TiO 2 -Chitosan-Berbamine nanocomposites. We examined nanocomposites using XRD, DLS, FESEM, TEM, PL, EDAX, and FTIR spectroscopy, as well as MTT for cytotoxicity, and AO/EtBr for apoptotic morphology assessment. The rate of apoptosis and cell cycle arrests was determined using flow cytometry. Flow cytometry was also employed to identify pro- and antiapoptotic proteins such as Bcl2, Bad, Bax, P53, and Cyt C. The FTIR spectrum revealed that the CuO-TiO 2 -Chitosan-Berbamine nanocomposites were electrostatically interlocked. The nanocomposites' XRD signals revealed a hexagonal shape. In the DLS spectrum, nanocomposites were found to have a hydrodynamic diameter. As a result of their cytotoxic action, nanocomposites displayed concentration-dependent cytotoxicity. The nanocomposites, like Doxorubicin, caused cell cycle phase arrest in K562 cells. After treatment with IC 50 concentrations of CuO-TiO 2 -Chitosan-Berbamine nanocomposites and Doxorubicin, a substantial percentage of cells were in G2/M stage arrest. Caspase-3, -7, -8, -9, Bax, Bad, Cyt C, and P53 expression were considerably enhanced in K562 cells, whereas Bcl2 expression was decreased, indicating that these cells may have therapeutic potential against human blood cancer/leukemia-derived disorders. As a result, the nanocomposites demonstrated outstanding anticancer potential against leukemic cells. CuO-TiO 2 -Chitosan-Berbamine, according to our findings.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

[Retracted] CuO‐TiO2‐Chitosan‐Berbamine Nanocomposites Induce Apoptosis through the Mitochondrial Pathway with the Expression of P53, BAX, and BCL‐2 in the Human K562 Cancer Cell Line

Elderdery

Alzahrani

Hamza

et al. 2022

Bioinorganic Chemistry and Applications

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“…It is one of the compounds obtained from the alcoholic extract of the flower buds of Dianthus caryophyllus, the extract showed antibacterial activities against the pathogenic bacteria E. coli and S. aureus (25). The compound 1,1,1,5,7,7,7-Heptamethyl-3,3bis(trimethylsiloxy)tetrasiloxane is among the compounds present in the extract of the stem and fruits of Berberis vulgaris, which showed antibacterial activities against caries-causing bacteria (27). 3-Trimethylsilyloxystearic acid is among the compounds present in the methanolic extract of Orobanche crenata, the extract showed strong antioxidant properties and inhibition of the spread of human hepatocellular carcinoma (HepG2), human prostate cancer (PC3), human breast cancer (MCF-7), and human colon carcinoma (HCT-116) (19).…”

Section: Effects Of Endophytic Fungal Filtrates On the Growth Of Some...mentioning

confidence: 99%

Antagonistic Activity of Endophytic Fungi Isolated From Aloe Vera Leaves Against Some Plant Pathogenic Fungi

M. A. A. Al Nuaimy,

S. N. Hawar

2024

Iraqi J. Agric. Sci.

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The present study was aimed to test the antagonistic activity of endophytic fungi isolated from Aloe vera leaves against a number of plant-pathogenic fungi. The results showed that the highest antagonistic activity was exerted by Penicillium chermesinum against the pathogenic fungus Rhizoctonia solani, with an inhibition rate of 78.57%. Also, Talaromyces verruculosus and P. chermesinum showed their highest antagonistic activities against pathogenic fungus Fusarium 1 with inhibition rates of 61.79% and 61.53%, respectively, while T. verruculosus showed an inhibition rate of 62.91% against the pathogenic fungus Fusarium 2. Most of the endophytic fungi showed the least percentage of inhibition against Macrophomina phaseolina compared to the rest of the pathogenic fungi. The fungal filtrates showed a concentration-dependent inhibition rate against the plant pathogens, with a range of 0.00-48.13%. The highest inhibitory activity of Aspergillus niger was recorded at a concentration of 60% against Fusarium 2, R. solani, and Fusarium 1, with rates of 48.13, 37.39, and 36.66%, respectively. The results also showed the ineffectiveness of all fungal filtrates against the pathogenic fungus M. phaseolina. Chemical analysis of the filtrates of the endophytic fungi which showed antagonistic activity against pathogenic fungi was also conducted by using GC-MS. The results showed the presence of effective compounds with biological effects, such as Pentadecanoic acid, Oleic Acid, Limonene, cis-Vaccenic acid, Hexanedioic acid, bis(2-ethylhexyl) ester, Cycloheptasiloxane, and tetracamethyl-.

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“…Recently, Arkadiusz Dziedzic et al ( 16 ) found that berberine can effectively inhibit the growth of S. mutans in vitro . Maryam Kazemipoor et al ( 22 ) reported that barberry plant extract and CHX (chlorhexidine) have similar antimicrobial activity against S. mutans . However, in our knowledge, the antibiofilm effect of berberine on S. mutans has received little or no attention.…”

Section: Introductionmentioning

confidence: 99%

The inhibitory effect of berberine chloride hydrate on Streptococcus mutans biofilm formation at different pH values

Zhou,

Liu,

Wen

et al. 2023

Microbiol Spectr

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Streptococcus mutans ( S. mutans ) is one of the major cariogenic bacteria of dental caries owing to its ability to adhere to tooth surfaces and biofilm formation. Berberine chloride hydrate (BH), a quaternary ammonium salt alkaloid, has diverse pharmacological efforts against microorganisms. However, the effect of BH on S. mutans biofilm has not been reported. Considering that berberine is a quaternary ammonium salt alkaloid, which needs to adapt to a large variation in pH values and the acid resistance of S. mutans , we employed three groups including pH 5 (acidic), pH 8 (alkaline), and unprocessed group (neutral) to examine the antibiofilm activities of BH against S. mutans during different pH values. In this study, we found BH effectively suppresses S. mutans biofilm formation as well as its cariogenic virulence including acid production and EPS synthesis significantly, and the inhibitory effort was reduced under acidic condition whereas elevated under alkaline condition. In addition, we preliminarily explored the influence of pH values on the structural stability and biosafety of BHas well as the underlying mechanism of inhibition of S. mutans biofilm formation with BH. Our study showed BH could maintain a good structural stability and low toxicity to erythrocytes at different pH values. And BH could downregulate the expression of srtA, spaP, and gbpC, which play critical roles in the adhesion process, promoting bacterial colonization and biofilm formation. Furthermore, comX and ldh expression levels were downregulated in BH-treated group, which might explain its inhibitory effect on acid production. IMPORTANCE Dental caries is a common chronic detrimental disease, which could cause a series of oral problem including oral pain, difficulties in eating, and so on. Recently, many natural products have been considered as fundamental sources of therapeutic drugs to prevent caries. Berberine as a plant extract showed good antibiofilm abilities against microorganism. Our study focuses on its antibiofilm abilities against S. mutans, which was defined as major cariogenic bacterium and explored the role of pH values and possible underlying mechanisms in the inhibitory effect of BH on S. mutans biofilm formation. This study demonstrated a promising prospect for BH as an adjuvant drug in the prevention and management of dental caries.

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Chemical composition and antibacterial activity of Berberis vulgaris (barberry) against bacteria associated with caries

Cited by 11 publications

References 37 publications

[Retracted] CuO‐TiO2‐Chitosan‐Berbamine Nanocomposites Induce Apoptosis through the Mitochondrial Pathway with the Expression of P53, BAX, and BCL‐2 in the Human K562 Cancer Cell Line

[Retracted] CuO‐TiO2‐Chitosan‐Berbamine Nanocomposites Induce Apoptosis through the Mitochondrial Pathway with the Expression of P53, BAX, and BCL‐2 in the Human K562 Cancer Cell Line

Antagonistic Activity of Endophytic Fungi Isolated From Aloe Vera Leaves Against Some Plant Pathogenic Fungi

The inhibitory effect of berberine chloride hydrate on Streptococcus mutans biofilm formation at different pH values

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