CHEMICAL COMPOSITION AND ANTIBACTERIAL ACTIVITIES OF HOMALOMENA VIETNAMENSIS BOGNER &amp; V. D. NGUYEN (ARACEAE)

Van, Hong Thien; Nguyen, Quang Phuc; Tran, Gia-Buu; Huynh, Nguyen Tuong An

doi:10.15414/jmbfs.2020.10.2.201-204

Cited by 3 publications

(1 citation statement)

References 9 publications

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“…septica, and H. rubescens have also been identified to have antibacterial, antifungal and anticancer effects (Vijayaraghavan et al, 2017;Jangad and Licardo, 2018;Haryanti et al, 2021;Van et al, 2021).…”

Section: Discussionmentioning

confidence: 99%

Phytochemical composition and antibacterial activity of selected medicinal plants in a local community in the Philippines

2023

Int. J. Biosci.

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A survey of medicinal plants in a local community in Guimbal, Iloilo, Philippines identified ten plant species namely, hagonoy (Chromolaena odorata), pitogo (Cycas rumphii), adgao (Premna odorata), labnog (Ficus leucantatoma), talus (Homalomena rubescens), sinaw-sinaw (Peperomia pellucida), palochina (Senna alata), badyang (Alocasia macrorrhizos); bagacay (Bambusa vulgaris) and karupi (Alpinia sp). From these plants, two least-studied medicinal plants, B. vulgaris and Alpinia sp. were determined of their phytochemical composition and antibacterial properties following standard procedures. Aqueous and ethanolic extracts were prepared from these plants and the antibacterial activity of the extracts against two Gram-negative bacteria, Aeromonas hydrophila and Vibrio harveyi, and a Gram-positive, spore-forming bacterium, Bacillus albus were determined using Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC).Phytochemical analyses of B. vulgaris and Alpinia sp., indicated the presence of alkaloids, carbohydrates, glycosides, phytosterols, flavonoids and phenols and tannins. All extracts of the two medicinal plants inhibited the growth of A. hydrophila at a concentration of 0.5 g ml -1 . The MBC and MIC for B. vulgaris aqueous extract and Alpinia sp. ethanolic extract against V. harveyi showed inhibition at 0.5g ml -1 except for the MIC of B. vulgaris aqueous extract which was at 0.25 g ml -1 . There was no inhibition of B. albus from all extracts of both medicinal plants. These two medicinal plants can be further explored as potential sources of ingredients for the development of novel antibacterial drugs particularly in inhibiting Gram-negative bacteria.

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Section: Discussionmentioning

confidence: 99%

Phytochemical composition and antibacterial activity of selected medicinal plants in a local community in the Philippines

2023

Int. J. Biosci.

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Homalolides C-D, two new sesquiterpenoids from the rhizomes of Homalomena pendula

Nguyen

Hoang

Anh

et al. 2022

Natural Product Research

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Two new sesquiterpenoids, homalolides CD (1-2), were co-isolated from the rhizomes of Homalomena pendula collected in Vietnam with five known ones, aromadendrane-4α,10αdiol (3), bullatantriol (4), 1β,4β,6α-trihydroxy-eudesmane (5), 1β,4β,6β-trihydroxyeudesmane (6), and 1β,4β,7α-trihydroxy-eudesmane (7). The structures and relative configuration of new compounds were elucidated by 1D-/2D-NMR, IR, UV and HRESIMS analyses, and by comparisons to the reported data in the literature. Homalolide C presented an unprecedented skeleton with the 4/8 bicyclic system. All isolates did not exhibit appreciable inhibitory effects on LPS-induced NO production in the RAW 264.7 macrophage cell line and on the growth of human lung cancer cell line (SK-LU-1).

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Investigation of Potential Antioxidant, Thrombolytic and Neuropharmacological Activities of Homalomena aromatica Leaves Using Experimental and In Silico Approaches

et al. 2021

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The leaves of Homalomena aromatica are traditionally used in Bangladesh for the treatment of different chronic ailments. The purpose of this study was to explore in vitro antioxidant, thrombolytic activities, and in vivo neuropharmacological effects of methanolic extract of Homalomena aromatica (MEHA) leaves. Antioxidant activity of MEHA was assessed by a DPPH free radical scavenging assay and total phenolics content, total flavonoids content were also measured. The thrombolytic activity was determined by percentage of clot lysis and neuropharmacological activities by hole board, tail suspension, forced swimming and elevated plus maze tests. The results showed that the IC50 value of the extract against DPPH was 199.51 μg/mL. Quantitative analysis displayed higher contents of phenolics and flavonoids (147.71 mg gallic acid equivalent/g & 66.65 mg quercetin equivalent/g dried extract, respectively). The extract also showed a significant clot lysis (33.31%) activity. In case of anxiolytic activity, the elevate plus maze (EPM) test demonstrated an increase in time spent in open arms, and in case of hole board test, the number of head dipping was also significantly increased (p < 0.05). All the test compared with control (1% Tween in water) and standard (diazepam 1 mg/kg), significant dose (200 & 400 mg/kg) dependent anxiolytic activity was found. In antidepressant activity, there was a significant decrease in period of immobility in both test models (tail suspension and forced swimming) (p < 0.05). Moreover, 13 compounds were identified as bioactive, showed good binding affinities to xanthine oxidoreductase, tissue plasminogen activator receptor, potassium channel receptor, human serotonin receptor targets in molecular docking experiments. Furthermore, ADME/T analysis revealed their drug-likeness, likely pharmacological actions and non-toxic upon consumption. Taken together, our finding support the traditional medicinal use of this plant, which may provide a potential source for future drug discovery.

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CHEMICAL COMPOSITION AND ANTIBACTERIAL ACTIVITIES OF HOMALOMENA VIETNAMENSIS BOGNER & V. D. NGUYEN (ARACEAE)

Cited by 3 publications

References 9 publications

Phytochemical composition and antibacterial activity of selected medicinal plants in a local community in the Philippines

Phytochemical composition and antibacterial activity of selected medicinal plants in a local community in the Philippines

Homalolides C-D, two new sesquiterpenoids from the rhizomes of Homalomena pendula

Investigation of Potential Antioxidant, Thrombolytic and Neuropharmacological Activities of Homalomena aromatica Leaves Using Experimental and In Silico Approaches

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