Chemical composition and antibacterial activities of essential oils from rhizomes and aerial parts of <i>Homalomena cochinchinensis</i> (Araceae)

Doan

et al. 2023

In this study, we analyzed the volatile constituents of the n-hexane extract from the rhizomes of Homalomena cochinchinensis Engl. by gas chromatography-mass spectrometry (GC-MS). We also investigated the anti-inflammatory, acetylcholinesterase (AChE) inhibitory, and cytotoxic activities of this extract. GC-MS analysis revealed the presence of 25 compounds, of which linalool was the primary component (17.6%). The extract significantly inhibited lipopolysaccharide-induced production of nitric oxide in RAW264.7 cells (IC50 = 21.08 ± 1.80 µg/mL); displayed weak cytotoxic activity against SK-LU-1, HepG2, and MCF7 cancer cell lines (IC50 values ranged from 154.60 to 184.25 µg/mL); and exhibited a weak capacity for AChE inhibition (IC50 = 131.10 ± 9.76 µg/mL). This report is the first to examine the volatile components and biological activities of the n-hexane extract from rhizomes of Homalomena cochinchinensis.

Section: Resultscontrasting

confidence: 59%

Section: Introductionmentioning

confidence: 99%

Volatile Components and Biological Activities of n-Hexane Extract From Rhizomes of Homalomena cochinchinensis

Doan

et al. 2023

“…Previous studies showed that linalool and terpinen-4-ol were the major components of the rhizome oils of H. aromatica, H. cochinchinesis, H. occulta, and H. sagittifolia. [25][26][27][28][29][30][31][32] These results demonstrate the close phylogenetic relationships between H. aromatica, H. cochinchinesis, H. occulta, H. sagittifolia, and H. gigantea.…”

Section: Resultsmentioning

confidence: 67%

Volatile Constituents and Anti-Osteoporotic Activity of the n-Hexane Extract From Homalomena gigantea Rhizome

Pham

Ngo

Dang

et al. 2022

This study analyzed the chemical composition and anti-osteoporosis activity of the n-hexane extract of Homalomena gigantea rhizome. Sixty compounds, representing 92.0% of the extract, were identified by gas chromatography-mass spectrometry. Linalool (15.3%), oplopanone (9.8%), ( Ε)-α-atlantone (5.6%), khusinol acetate (5.4%), bullatantriol (4.3%), and β-sitosterol (3.8%) were the main constituents. The anti-osteoporotic activity of the n-hexane extract was determined by measuring alkaline phosphatase (ALP) activity, collagen content, and the mineralization of MC3T3-E1 cells. At concentrations of 4.0 and 20.0 µg/mL, the n-hexane extract increased ALP activity by 8.2% and 23.7%, and increased collagen secretion by MC3T3-E1 cells by 114.9% and 112.4%, respectively. At 4 µg/mL, the extract significantly promoted the mineralization of MC3T3-E1 cells by as much as 133.2% compared to the negative control. These results suggested that H. gigantea rhizome contains a natural anti-osteoporotic compound.

“…Furthermore, we compared the chemical composition of H. cochinchinensis rhizome essential oil with that of essential oil from the aerial parts of the plant. 7 This comparison revealed substantial differences in the prevalence of the primary components. Specifically, Van et al 7 reported that myrcene (41.1%), sabinene (8.2%), and d -limonene (9.1%) are the main constituents in the essential oil from the aerial parts of H. cochinchinensis ; however, these compounds were only minor components of our H. cochinchinensis rhizome essential oil (0.7%, 1.0%, and 0.8%, respectively).…”

Section: Resultsmentioning

confidence: 95%

Phytochemical Composition and Bioactivities of Essential Oils from Rhizomes of Homalomena pendula and Homalomena cochinchinensis

Doan

et al. 2023

In this study, we investigated the chemical composition and potential biological properties of essential oils extracted from the rhizomes of two Homalomena species, H. pendula (Blume) Bakh.f. and H. cochinchinensis Engl. Using GC–MS analysis, we found that H. pendula essential oil contains 59 components while H. cochinchinensis essential oil contains 58. Both essential oils were rich in oxygenated monoterpenes, with linalool and terpinen-4-ol being the most prevalent compounds. Additionally, H. cochinchinensis essential oil exhibited moderate anti-inflammatory activity with an IC50 value of 170.81 ± 11.44 µg/mL, whereas H. pendula essential oil showed moderate activity against acetylcholinesterase (AChE) with an IC50 value of 130.65 ± 1.27 µg/mL. This study is the first to report the chemical composition and biological effects of H. pendula essential oil, as well as the anti-inflammatory effects of H. cochinchinensis essential oil.