Chemical composition and acetylcholinesterase inhibitory activity of essential oils of Myrceugenia myrcioides(Cambess.) O. Berg and Eugenia riedelianaO. Berg, Myrtaceae

Souza, Amanda de; Lopes, Elaine Cristina; Silva, Michelle C. da; Cordeiro, Inês; Young, Maria Cláudia Marx; Sobral, Marcos; Moreno, Paulo Roberto Hrihorowitsch

doi:10.1590/s0102-695x2010000200007

Cited by 19 publications

(12 citation statements)

References 21 publications

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“…Essential oils are mixtures of many bioactive compounds whose occurrence are strongly dependent on wide range of factors ranging from plant species used [3] the part of the plant used [4] , the season the plant was harvested [5] , population differences of the same species [6] , or even between individuals of the same population [7] , [8] . Although the bio-inhibitory effect of an essential oil could be explained in terms of the individual effects or joint effects of some main constituents there is still little knowledge on the nature of interaction between these compounds.…”

Section: Discussionmentioning

confidence: 99%

In-vitro anti-cholinesterase activity of essential oil from four tropical medicinal plants

et al. 2015

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The chemical inhibition of acetyl-cholinesterase (AChE) is a potent strategy for addressing signal related neuropathology and natural products are potential sources of compounds with such properties. Essential oil extracts from leaf, seed, stem and rhizome of four medicinal plants [Aframomum melegueta K. Schum, Crassocephalum crepidioides (Benth S. More), Monodora myristica (Gaertn.), and Ocimum gratissimum (Linn)] were tested for acetyl-cholinesterase inhibitory activity (AChEI) using Ellman's colorimentric method and compared to a reference acetyl-cholinesterase inhibitor (galantamine). The seed (IC50 = 6.71 mg/l) and leaf (IC50 = 6.54 mg/l) extracts from O. gratissimum showed values that matched the capacity of the reference inhibitor (IC50 = 6.62 mg/l). The least potent extract was rhizome extracts of A. melegueta (IC50 = 28.97 mg/l) about four times that of the reference inhibitor. Principal component analysis (PCA) showed that the intrinsic properties (bioactive ingredient factor) of each extract (PC1 = 29.50%) was the most important factor defining the difference or similarity in potency to the reference acetyl-cholinesterase inhibitor while ‘dose response’ (PC2 = 11.38%) was the second most important factor. The outstanding AChEI property of O. gratissimum extracts could largely be attributed to the high monoterpene content while the weak potency of rhizome extracts of A. melegueta may be attributed to its predominant concentrations of sesquiterpenes. Since potency could be related to interaction between bioactive components, understanding the interaction between ratios of monoterpene and sesquiterpene in extracts could be important in determining their potency for AChEI.

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Section: Discussionmentioning

confidence: 99%

In-vitro anti-cholinesterase activity of essential oil from four tropical medicinal plants

et al. 2015

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“…The IC 50 values were obtained for the hydroalcoholic extract, the essential oil, beta-asarone, and alpha-asarone and were 182.31 ± 16.78 µg/mL, 10.67 ± 0.81 µg/mL, 3.33 ± 0.02 µM, and 46.38 ± 2.69 µM, respectively. Souza et al [19] reported the AChE inhibitory activity of the essentials oils from Myrceugenia myrcioides (Cambess.) O. Berg and Eugenia riedeliana O. Berg.…”

Section: Cholinesterase Inhibitory Effect Of the Essential Oil MIXmentioning

confidence: 99%

Cognitive Facilitation and Antioxidant Effects of an Essential Oil Mix on Scopolamine-Induced Amnesia in Rats: Molecular Modeling of In Vitro and In Vivo Approaches

et al. 2020

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The present study investigated the capability of an essential oil mix (MO: 1% and 3%) in ameliorating amnesia and brain oxidative stress in a rat model of scopolamine (Sco) and tried to explore the underlying mechanism. The MO was administered by inhalation to rats once daily for 21 days, while Sco (0.7 mg/kg) treatment was delivered 30 min before behavioral tests. Donepezil (DP: 5 mg/kg) was used as a positive reference drug. The cognitive-enhancing effects of the MO in the Sco rat model were assessed in the Y-maze, radial arm maze (RAM), and novel object recognition (NOR) tests. As identified by gas chromatography–mass spectrometry (GC–MS), the chemical composition of the MO is comprised by limonene (91.11%), followed by γ-terpinene (2.02%), β-myrcene (1.92%), β-pinene (1.76%), α-pinene (1.01%), sabinene (0.67%), linalool (0.55%), cymene (0.53%), and valencene (0.43%). Molecular interactions of limonene as the major compound in MO with the active site of butyrylcholinesterase (BChE) was explored via molecular docking experiments, and Van der Waals (vdW) contacts were observed between limonene and the active site residues SER198, HIS438, LEU286, VAL288, and PHE329. The brain oxidative status and acetylcholinesterase (AChE) and BChE inhibitory activities were also determined. MO reversed Sco-induced memory deficits and brain oxidative stress, along with cholinesterase inhibitory effects, which is an important mechanism in the anti-amnesia effect. Our present findings suggest that MO ameliorated memory impairment induced by Sco via restoration of the cholinergic system activity and brain antioxidant status.

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“…(( E )-nerolidol, 24.6% and α-pinene, 24.0%) [ 27 ], E. verticillata (Vell.) Angely (valerianol, 28.1% and 10- epi -γ-eudesmol, 12.6%) [ 64 ], and E. xiriricana Mattos (spathulenol, 15.4% and β-pinene, 14.1%) [ 32 ]. In addition, three species presented other constituents such as esters, carboxylic acid, and oxygenated monoterpenes as main compounds.…”

Section: Volatile Profilesmentioning

confidence: 99%

Essentials Oils from Brazilian Eugenia and Syzygium Species and Their Biological Activities

et al. 2020

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The Eugenia and Syzygium genera include approximately 1000 and 1800 species, respectively, and both belong to the Myrtaceae. Their species present economic and medicinal importance and pharmacological properties. Due to their chemical diversity and biological activity, we are reporting the essential oils of 48 species of these two genera, which grow in South America and found mainly in Brazil. Chemically, a total of 127 oil samples have been described and displayed a higher intraspecific and interspecific diversity for both Eugenia spp. and Syzygium spp., according to the site of collection or seasonality. The main volatile compounds were sesquiterpene hydrocarbons and oxygenated sesquiterpenes, mainly with caryophyllane and germacrane skeletons and monoterpenes of mostly the pinane type. The oils presented many biological activities, especially antimicrobial (antifungal and antibacterial), anticholinesterase, anticancer (breast, gastric, melanoma, prostate), antiprotozoal (Leishmania spp.), antioxidant, acaricidal, antinociceptive and anti-inflammatory. These studies can contribute to the rational and economic exploration of Eugenia and Syzygium species once they have been identified as potent natural and alternative sources to the production of new herbal medicines.

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Chemical composition and acetylcholinesterase inhibitory activity of essential oils of Myrceugenia myrcioides(Cambess.) O. Berg and Eugenia riedelianaO. Berg, Myrtaceae

Cited by 19 publications

References 21 publications

In-vitro anti-cholinesterase activity of essential oil from four tropical medicinal plants

In-vitro anti-cholinesterase activity of essential oil from four tropical medicinal plants

Cognitive Facilitation and Antioxidant Effects of an Essential Oil Mix on Scopolamine-Induced Amnesia in Rats: Molecular Modeling of In Vitro and In Vivo Approaches

Essentials Oils from Brazilian Eugenia and Syzygium Species and Their Biological Activities

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