Chemical composition and acaricidal activity of the essential oil of Baccharis dracunculifolia De Candole (1836) and its constituents nerolidol and limonene on larvae and engorged females of Rhipicephalus microplus (Acari: Ixodidae)

Lage, Tiago Coelho de Assis; Montanari, Ricardo Marques; Fernandes, Sérgio Antônio; Monteiro, Caio Márcio de Oliveira; Senra, Tatiane de Oliveira Souza; Zeringóta, Viviane; Matos, Renata da Silva; Daemon, Erik

doi:10.1016/j.exppara.2014.10.011

Cited by 45 publications

(14 citation statements)

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“…2005) and acari (de Assis Lage et al. 2015). Recently, nerolidol was proven to exert antinociceptive activity mediated by the GABAergic system, and anti-inflammatory activity decreasing TNF-α and IL-1β proinflammatory cytokines (Fonsêca et al.…”

Section: Resultsmentioning

confidence: 99%

Phytochemical investigations and antiproliferative secondary metabolites from Thymus alternans growing in Slovakia

Dall’Acqua

Peron

Ferrari

et al. 2017

Pharmaceutical Biology

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Context:Thymus alternans Klokov (Lamiaceae) is a neglected species of the genus Thymus (Sect. Serpyllum) endemic to Carpathian area, where it is used as a flavouring agent and for medicinal purposes.Objective: The aim of the work was to identify antiproliferative constituents from the flowering aerial parts of this plant.Materials and methods:Thymus alternans extracts were analyzed by HPLC-MSn and subjected to extensive chromatographic separations. The isolated compounds (phenolics and triterpenes) were structurally elucidated by MS and 1D and 2D NMR experiments. Essential oil (EO) composition was determined by GC-FID and GC-MS. Six purified triterpenes and EO were assayed for in vitro antiproliferative activity against a panel of human cancer cells, namely, breast (MDA-MB 231), colon (HCT-15 and HCT116), lung (U1810), pancreatic (BxPC3), melanoma (A375) and cervical carcinoma (A431) cells.Results: The structures of the isolated compounds were achieved on the basis of H-NMR and MS experiments. Luteolin-4′-O-β-d-glucopyranoside (P1), chrysoeriol-7-O-β-d-glucopyranoside (P2), chrysoeriol-5-O-β-d-glucopyranoside (P3), apigenin-7-O-β-d-glucopyranoside (P4), rosmarinic acid (P5), rosmarinic acid-3′-O-β-d-glucopyranoside (P6), caffeic acid-3-O-β-d-glucopyranoside (P7), 3α-hydroxy-urs-12,15-diene (T1), α-amyrin (T2), β-amyrin (T3), isoursenol (T4), epitaraxerol (T5), and oleanolic acid (T6). GC-MS analysis revealed that the EO of T. alternans was devoid of phenols and belonged to the nerolidol-chemotype, that is typical of the Sect. Serpyllum. The six purified triterpenes (T1-T6) were active with IC50 ranging from 0.5 to 5 μM being comparable or better than those of reference compounds betulinic acid and cisplatin. The EO exhibited significant effects on A375, MDA-MB 231 and HCT116 cell lines with IC50 in the range of 5–8 μg/mL.Conclusion: The reported results suggest that T. alternans can be considered as a good source of phytoconstituents with possible importance in the pharmaceutical field.

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Section: Resultsmentioning

confidence: 99%

Phytochemical investigations and antiproliferative secondary metabolites from Thymus alternans growing in Slovakia

Dall’Acqua

Peron

Ferrari

et al. 2017

Pharmaceutical Biology

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“…Thus, the essential oil extracted from the Tunisian plant, and more precisely from its flowers, is very rich in (E)-nerolidol, since it is present at 40% of the total volatile constituents (Table 2). (E)-nerolidol is an odorant compound prized by the perfume industry (18) but some studies have shown that it may have anti-parasitic (19), anti-malarial (20), anti-mite (21) and cytotoxic (22) properties. A recent study has even highlighted the effect of RT*: Retention time, RI: Retention index determined on a HP5-MS fused silica column relative to a series of n-alkanes (C8-C26), tr: trace, percentage lower than 0.1% (E)-nerolidol and caryophyllene oxide (23) on some cancer cells.…”

Section: Component Identificationmentioning

confidence: 99%

Chemical composition, antibacterial and antioxidant activities of essential oils from flowers, leaves and aerial parts of Tunisian Dittrichia Viscosa

Gharred

Dbeibia

Falconieri

et al. 2019

Journal of Essential Oil Research

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The objective of this work was to determine the chemical composition, the antioxidant and antibacterial activities of the essential oils (EOs) extracted by hydrodistillation from different organs of the D. viscosa: flowers, leaves and aerial parts. The main compounds identified by GC/MS are oxygenated sesquiterpenes. Among these compounds, (E)-nerolidol (40.7%) is the most abundant constituent of flowers' essential oil while caryophyllene oxide (9.9%), isolongifolan-7-α-ol (10.3%) and α-eudesmol (9.1%) are the major constituents of the leaves' essential oil. The presence of these compounds in the aerial parts' essential oil is solely due to those of the flowers and leaves that constitute these aerial parts. The volatile extracts showed antioxidant effects with IC 50 values ranging between 9.25 and 9.75 mg.mL −1. On the other hand, EOs showed antibacterial effects on both Gram-positive and Gram-negative bacteria. The highest activity was obtained with flowers' essential oil against Enterococcus faecalis and Escherichia coli.

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“…Monoterpenoids and sesquiterpenoids are frequently found in the EOs of Baccharis [ 3 , 30 ]. Sesquiterpenoids seemed to be more abundant in the majority of the species [ 3 , 6 , 7 , 16 , 22 , 30 , 31 , 32 , 33 ]. However, the EO of some species contained more monoterpenoids than sesquiterpenoids, such as in B. obovata [ 21 ], B. schultzii , B. regnelli Sch.…”

Section: Resultsmentioning

confidence: 99%

Essential Oils of Five Baccharis Species: Investigations on the Chemical Composition and Biological Activities

et al. 2018

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This paper provides a comparative account of the essential oil chemical composition and biological activities of five Brazilian species of Baccharis (Asteraceae), namely B. microdonta, B. pauciflosculosa, B. punctulata, B. reticularioides, and B. sphenophylla. The chemical compositions of three species (B. pauciflosculosa, B. reticularioides, and B. sphenophylla) are reported for the first time. Analyses by GC/MS showed notable differences in the essential oil compositions of the five species. α-Pinene was observed in the highest concentration (24.50%) in B. reticularioides. Other major compounds included α-bisabolol (23.63%) in B. punctulata, spathulenol (24.74%) and kongol (22.22%) in B. microdonta, β-pinene (18.33%) and limonene (18.77%) in B. pauciflosculosa, and β-pinene (15.24%), limonene (14.33%), and spathulenol (13.15%) in B. sphenophylla. In vitro analyses for antimalarial, antitrypanosomal, and insecticidal activities were conducted for all of the species. B. microdonta and B. reticularioides showed good antitrypanosomal activities; B. sphenophylla showed insecticidal activities in fumigation bioassay against bed bugs; and B. pauciflosculosa, B. reticularioides, and B. sphenophylla exhibited moderate antimalarial activities. B. microdonta and B. punctulata showed cytotoxicity. The leaves and stems of all five species showed glandular trichomes and ducts as secretory structures. DNA barcoding successfully determined the main DNA sequences of the investigated species and enabled authenticating them.

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Chemical composition and acaricidal activity of the essential oil of Baccharis dracunculifolia De Candole (1836) and its constituents nerolidol and limonene on larvae and engorged females of Rhipicephalus microplus (Acari: Ixodidae)

Cited by 45 publications

References 40 publications

Phytochemical investigations and antiproliferative secondary metabolites from Thymus alternans growing in Slovakia

Phytochemical investigations and antiproliferative secondary metabolites from Thymus alternans growing in Slovakia

Chemical composition, antibacterial and antioxidant activities of essential oils from flowers, leaves and aerial parts of Tunisian Dittrichia Viscosa

Essential Oils of Five Baccharis Species: Investigations on the Chemical Composition and Biological Activities

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