Chemical Characterization, Phytotoxic, Antimicrobial and Insecticidal Activities of<i>Vitex agnus-castus</i>’ Essential Oil from East Mediterranean Region

Ulukanlı, Zeynep; Çenet, Menderes; Öztürk, Bintuğ; Bozok, Fuat; Karabörklü, Salih; Demirci, Salih Cercis

doi:10.1080/0972060x.2015.1004125

Cited by 23 publications

(18 citation statements)

References 8 publications

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“…Additionally, the EO of Vitex agnus-castus was reported to be rich with monoterpenes, particularly 1,8-cineole, sabinene, trans-β -farnesene, and α -pinene. This EO was found to exhibit significant inhibitory activity on Lactuca sativa and Lepidium sativum [ 24 ].…”

Section: Phytotoxic Eos Derived From Plants Rich In Monoterpenesmentioning

confidence: 99%

Phytotoxic Effects of Plant Essential Oils: A Systematic Review and Structure-Activity Relationship Based on Chemometric Analyses

Abd‐ElGawad

Gendy

Assaeed

et al. 2020

Plants

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Herbicides are natural or synthetic chemicals used to control unwanted plants (weeds). To avoid the harmful effects of synthetic herbicides, considerable effort has been devoted to finding alternative products derived from natural sources. Essential oils (EOs) from aromatic plants are auspicious source of bioherbicides. This review discusses phytotoxic EOs and their chemical compositions as reported from 1972 to 2020. Using chemometric analysis, we attempt to build a structure-activity relationship between phytotoxicity and EO chemical composition. Data analysis reveals that oxygenated terpenes, and mono- and sesquiterpenes, in particular, play principal roles in the phytotoxicity of EOs. Pinene, 1,8 cineole, linalool, and carvacrol are the most effective monoterpenes, with significant phytotoxicity evident in the EOs of many plants. Caryophyllene and its derivatives, including germacrene, spathulenol, and hexahydrofarnesyl acetone, are the most effective sesquiterpenes. EOs rich in iridoids (non-terpene compounds) also exhibit allelopathic activity. Further studies are recommended to evaluate the phytotoxic activity of these compounds in pure forms, determine their activity in the field, evaluate their safety, and assess their modes of action.

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Section: Phytotoxic Eos Derived From Plants Rich In Monoterpenesmentioning

confidence: 99%

Phytotoxic Effects of Plant Essential Oils: A Systematic Review and Structure-Activity Relationship Based on Chemometric Analyses

Abd‐ElGawad

Gendy

Assaeed

et al. 2020

Plants

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“…Two round filter papers were placed into each glass petri dish (90 mm in diameter) and then sterilized at 121 ∘ C for 15 min. Afterwards, sterilized seeds with aqueous sodium hypochlorite solution (1.5%, v/v) for 10 min were aseptically placed onto double layered membranes [32]. EO of T. cilicicum was dissolved in 0.5% Tween 80 at the concentrations from 0.062 to 2.0 mg/mL.…”

Section: Disc Diffusionmentioning

confidence: 99%

Essential Oil Constituents ofTanacetum cilicicum: Antimicrobial and Phytotoxic Activities

Ulukanlı

Demirci

Yılmaztekin

2017

Journal of Food Quality

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Aerial parts of Tanacetum cilicicum were hydrodistillated for 3 h using Clevenger. Essential oil (EO) yield was 0.4% (v/w). According to the GC/MS analyses, EO of T. cilicicum consisted of monoterpenes [ -pinene (2.95 ± 0.19%), sabinene (2.32 ± 0.11%), and limonene (3.17 ± 0.25)], oxygenated monoterpenes [eucalyptol (5.08 ± 0.32%), camphor (3.53 ± 0.27%), linalool (7.01 ± 0.32%), -terpineol (3.13 ± 0.23%), and borneol (4.21 ± 0.17%)], and sesquiterpenes [sesquisabinene hydrate (6.88 ± 0.41%), nerolidol (4.90 ± 0.33%), -muurolol (4.57% ± 0.35), spathulanol (2.98 ± 0.12%), juniper camphor (2.68 ± 0.19%), (-)-caryophyllene oxide (2.64 ± 0.19%), 8-hydroxylinalool (2.62 ± 0.15%), and Δ-cadinene (2.48 ± 0.16%)]. In the antimicrobial assay, MIC/MBC values of the EO were the most significant on B. subtilis (0.39/0.78 L/mL) and B. cereus (0.78/1.56 L/mL). The most prominent phytotoxic activities of the EO were observed on L. sativa, L. sativum, and P. oleracea. The results of the present study indicated that EO of T. cilicicum includes various medicinally and industrially crucial phytoconstituents that could be in use for industrial applications. The finding of this study is the first report on this species from the East Mediterranean region.

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“…The components and the quality of the extracted essential oil was investigated using gas chromatography (GC, Agilent Technologies 6890N Network system) with flame ionization detection (FID) detector GC/FID and gas chromatography combined with a mass selective detector GC/MS (Ulukanli, et al, 2015). Retention indices (RI) calculations were also confirmed with the results obtained from alkanes (C8-C32).…”

Section: Gas Chromatography-mass Spectrophotometry Analysismentioning

confidence: 91%

Antitumoral effects of Santolina chameacyparissus on Non-Small Cell Lung Cancer Cells

Kont¹,

Demir²,

Tok³

et al. 2021

JECM

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Santolina chameacyparissus (Santo) is an evergreen plant which is traditionally used for its anti-inflammatory effects in various diseases. In this study, we aimed to explore the effects of Santo in non-small cell lung cancer cells. We extracted volatile oil from the plant and evaluated cytotoxicity, apoptosis, and motility effects of the extract on two non-small cell lung cancer (NSCLC) cell lines; one is a patient derived and the other one is a commercially available A549 cells. We also identified its components via GC/MS and investigated possible targets of the major components of the plant using qPCR and docking studies. Cytotoxicity tests showed dose dependent cell killing activity and flow cytometry assays exposed apoptotic effects of Santo. The essential oil also remarkably decreased migration rate of A549 cells, therefore we evaluated the expression levels of epithelial to mesenchymal transition related genes E-cadherin and Vimentin ratio, ZEB1 and SNAIL and another motility related gene Ezrin. Santo did not change the expression of EMT related genes but decreased Ezrin levels. According to the results of the GS/MS analysis, Artemisia ketone and Camphor were identified as major molecules of the extract. Docking analysis also revealed that artemisia ketone, the major component of the Santo extract, potentially showed strong binding to the active site of ezrin protein and both artemisia ketone and camphor had ability to bind DNA. The results of the present study indicate that Santo and its components artemisia ketone and camphor are promising anti-cancer agents, and their potential in targeting DNA and oncogenic proteins in the lung cancer cells seems worth to focus on this plant in cancer related drug discovery science.

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Chemical Characterization, Phytotoxic, Antimicrobial and Insecticidal Activities ofVitex agnus-castus’ Essential Oil from East Mediterranean Region

Cited by 23 publications

References 8 publications

Phytotoxic Effects of Plant Essential Oils: A Systematic Review and Structure-Activity Relationship Based on Chemometric Analyses

Phytotoxic Effects of Plant Essential Oils: A Systematic Review and Structure-Activity Relationship Based on Chemometric Analyses

Essential Oil Constituents ofTanacetum cilicicum: Antimicrobial and Phytotoxic Activities

Antitumoral effects of Santolina chameacyparissus on Non-Small Cell Lung Cancer Cells

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