Chemical Characterization of Single Particles by Laser Ablation/Desorption in a Quadrupole Ion Trap Mass Spectrometer

Dale, John; Yang, Mo; Whitten, William B.; Ramsey, J. Michael

doi:10.1021/ac00092a021

Cited by 29 publications

(30 citation statements)

References 15 publications

(1 reference statement)

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“…In 1994, Dale et al, for example, began a distinct line of instrument development by creating a system using a quadrupole ion trap [14]. In that same year, Murhpy et al described a more conventional instrument [15,16] and in 1998 conducted unique studies sampling particles at 5 to 19 km from the nose of an airplane [17].…”

mentioning

confidence: 99%

Parameters contributing to efficient ion generation in aerosol MALDI mass spectrometry

McJimpsey

Jackson

Lebrilla

et al. 2008

J. Am. Soc. Mass Spectrom.

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The Bioaerosol Mass Spectrometry (BAMS) system was developed for the real-time detection and identification of biological aerosols using laser desorption ionization. Greater differentiation of particle types is desired; consequently MALDI techniques are being investigated. The small sample size (ϳ1 m 3 ), lack of substrate, and ability to simultaneously monitor both positive and negative ions provide a unique opportunity to gain new insight into the MALDI process. Several parameters known to influence MALDI molecular ion yield and formation are investigated here in the single particle phase. A comparative study of five matrices (2,6-dihydroxyacetophenone, 2,5-dihydroxybenzoic acid, ␣-cyano-4-hydroxycinnamic acid, ferulic ␣ acid, and sinapinic acid) with a single analyte (angiotensin I) is presented and reveals effects of matrix selection, matrix-to-analyte molar ratio, and aerosol particle diameter. The strongest analyte ion signal is found at a matrix-to-analyte molar ratio of 100:1. At this ratio, the matrices yielding the least and greatest analyte molecular ion formation are ferulic acid and ␣-cyano-␣ 4-hydroxycinnamic acid, respectively. Additionally, a significant positive correlation is found between aerodynamic particle diameter and analyte molecular ion yield for all matrices. SEM imaging of select aerosol particle types reveals interesting surface morphology and structure.

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mentioning

confidence: 99%

Parameters contributing to efficient ion generation in aerosol MALDI mass spectrometry

McJimpsey

Jackson

Lebrilla

et al. 2008

J. Am. Soc. Mass Spectrom.

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“…37 Dale et al demonstrated the detection of 2,4,6-trinitrotoluene (TNT) adsorbed on silicon carbide beads using a single-particle quadrupole ion trap mass spectrometer. 38 Time-of-flight SPAMS at Lawrence Livermore National Laboratory (LLNL) in the form of bioaerosol mass spectrometry (BAMS) has been applied to the detection of various species of Bacillus spores, [39][40][41][42][43][44][45] viruses, 39 toxin simulants, 39 fungi, 41 and Mycobacteria, 45 with and without the use of a chemical matrix during ionization. Matrix-free systems are ideal for real-time and on-line detection systems, as no sample preparation and thus very few reagents are needed for the analysis.…”

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confidence: 99%

Identification of High Explosives Using Single-Particle Aerosol Mass Spectrometry

et al. 2007

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The application of single-particle aerosol mass spectrometry (SPAMS) to the real-time detection of micrometersized single particles of high explosives is described. Dualpolarity time-of-flight mass spectra from 1000 single particles each of 2,4,6-trinitrotoluene (TNT), 1,3,5-trinitro-1,3,5-triazinane (RDX), and pentaerythritol tetranitrate (PETN), as well as those of complex explosives, Composition B, Semtex 1A, and Semtex 1H, were obtained over a range of desorption/ionization laser fluences between 0.50 and 8.01 nJ/µm 2 . Mass spectral variability with laser fluence for each explosive is discussed. The ability of the SPAMS system to identify explosive components in a single complex explosive particle (∼1 pg) without the need for consumables is demonstrated.

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“…This is a significant problem in the case of various complex mixture analyses of real microparticle samples. The wide variety of ion signals limits the quantitative evaluation of analyte concentration, due to the many experimental parameters such as shot-to-shot laser intensity, nonuniformity of particle size, different extents of overlap between laser beam and particle, and orientation of the particle surface interacting with the laser beam (23). The variety of intensities owing to particle size differences can be overcome if a standard-size particle material is used.…”

Section: Resultsmentioning

confidence: 99%

“…Recently, an ion trap mass spectrometer coupled with laser-induced ionization has been developed for the analysis of single microparticles (23)(24)(25)(26)(27). This technique has several advantages: an extremely small amount of a solid sample can be directly analyzed without sample manipulation, which prevents possible contamination during sample handling; the tandem mass analysis enables one to identify organic species and their molecular structures.…”

Section: Introductionmentioning

confidence: 99%

Identification of Aromatic Compounds on a Single Microparticle by Laser Desorption/Ionization Ion Trap Mass Spectrometry

Hong

Song

Cha

et al. 1999

Microchemical Journal

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Chemical Characterization of Single Particles by Laser Ablation/Desorption in a Quadrupole Ion Trap Mass Spectrometer

Cited by 29 publications

References 15 publications

Parameters contributing to efficient ion generation in aerosol MALDI mass spectrometry

Parameters contributing to efficient ion generation in aerosol MALDI mass spectrometry

Identification of High Explosives Using Single-Particle Aerosol Mass Spectrometry

Identification of Aromatic Compounds on a Single Microparticle by Laser Desorption/Ionization Ion Trap Mass Spectrometry

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