Chemical Characterization of Bioactive Components of<i>Rosa canina</i>Extract and Its Protective Effect on Dextran Sulfate Sodium-Induced Intestinal Bowel Disease in a Mouse Model

Wanes, Dalanda; Jabri, Mohamed-Amine; Tounsi, H.; Rtibi, Kaïs; Zouari, Nacim; Hajji, Najla; Jridi, Mourad; Abdellaoui, Afifa; Sebaï, Hichem

doi:10.1089/jmf.2019.0191

Cited by 6 publications

(2 citation statements)

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“…(Paunovic et al, 2019). However, studies on the species mostly focus on its fruits and pharmacological properties (Kerasioti et al 2019;Wanes et al 2020;Jemaa et al 2017). In a study on Nerium oleander, the presence of hemicelluloses and lignin in their structure was supported by the low calculated crystallinity index (CrI, 43.4%) and the small crystallite size (2.23) (Jabli et al 2018).…”

Section: Discussionmentioning

confidence: 99%

Identification of some fiber characteristics in Rosa sp. and Nerium oleander L. wood grown under different ecological conditions

Yiğit

Mutevelli

Şevik

et al. 2021

BioRes

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Climate-dependent changes in wood anatomical characteristics were studied for Rosa sp. and Nerium oleander sp. grown in phytosociological areas. For this purpose, wood samples were taken from the individual wood species grown in Antalya, Eskisehir, and Kastamonu provenances, where Terrestrial, Black Sea, and Mediterranean climate types prevail, and 11 anatomical characters were identified or calculated. As a result of the study, it has been determined that the climate has large effects on the characteristics that are the subject of the study and that each characteristic is at a higher level in individuals grown in areas where different climate types prevail. The highest values in Rosa species were obtained in the individuals grown under Terrestrial climate type in all characteristics except for LW (lumen widths), EC (elasticity coefficients), and FF (F-Factors.) Whereas in Nerium oleander, the highest values were obtained in individuals grown in the Mediterranean climate type in FL (fibre lengths), LW (lumen widths), FR (felting ratios), and EC (elasticity coefficients). For the same species type, in the Terrestrial climate, RIJID (rigidity coefficients), MUHT (Muhlstep ratios), and RUNK (Runkel ratios), and in the Black Sea climate DWT (double wall thicknesses) and WT (wall thicknesses) characteristics had high values.

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Section: Discussionmentioning

confidence: 99%

Identification of some fiber characteristics in Rosa sp. and Nerium oleander L. wood grown under different ecological conditions

Yiğit

Mutevelli

Şevik

et al. 2021

BioRes

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“…18 We used the well-established protocol in our laboratory on C57BL/6 mice to induce acute colitis using 5% DSS freshly prepared daily in distilled water as described in. [18][19][20] The key point in preparing the model is the monitoring signs of developing colitis by measuring the mice' s body weight and occult blood in the feces. Moreover, to prepare chronic colitis low concentration of DSS is used for a long time as we used in our previous publication.…”

Section: Experimental Designmentioning

confidence: 99%

Yarrow oil ameliorates ulcerative colitis in mice model via regulating the NF-κB and PPAR-γ pathways

et al. 2021

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Background/Aims: Ulcerative colitis (UC) is a chronic inflammatory disorder with indefinite etiology; however, environmental, genetic, immune factors and microbial agents could be implicated in its pathogenesis. UC treatment is lifelong, therefore; the potential side effects and cost of the therapy are significant. Yarrow is a promising medicinal plant with the ability to treat many disorders, owing to its bioactive compounds especially the essential oil. The main aim of this research was to investigate the therapeutic effect of the yarrow oil on colitis including the involved mechanism of action.Methods: In 21-female C57BL/6 mice were divided into 3 groups; control group, colitis model group, and oil-treated group. Groups 2 and 3 received 5% dextran sulfate sodium (DSS) in drinking water for 9 days, and concomitantly, only group 3 was given 100 mg/kg yarrow oil. Mice were examined for their body weight, stool consistency and bleeding, and the disease activity indexes were calculated.Results: Oral administration of yarrow oil markedly repressed the severity of UC via the reduction of the inflammatory signs and restoring colon length. The oil was able to down-regulate nuclear factor kappa light chain enhancer of activated B cells (NF-κB), up-regulate peroxisome proliferator-activated receptor gamma (PPAR-γ), and enhance transforming growth factor-β expression. The oil normalized the tumor necrosis factor-α expression, restored the normal serum level of interleukin-10 (IL-10) and reduced the serum level of IL-6.Conclusions: Yarrow oil mitigated UC symptoms and regulated the inflammatory cytokines secretion via regulation of NF-κB and PPAR-γ pathways in the mice model, however, this recommendation requires further investigations using clinical studies to confirm the use of the oil on humans.

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Rosa canina L.

Öğüt

2022

Novel Drug Targets With Traditional Herbal Medicines

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Chemical Characterization of Bioactive Components ofRosa caninaExtract and Its Protective Effect on Dextran Sulfate Sodium-Induced Intestinal Bowel Disease in a Mouse Model

Cited by 6 publications

References 64 publications

Identification of some fiber characteristics in Rosa sp. and Nerium oleander L. wood grown under different ecological conditions

Identification of some fiber characteristics in Rosa sp. and Nerium oleander L. wood grown under different ecological conditions

Yarrow oil ameliorates ulcerative colitis in mice model via regulating the NF-κB and PPAR-γ pathways

Rosa canina L.

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