Chemical characterization and toxicological assessment of hydroethanolic extract of Mandevilla velame xylopodium

Ribeiro, Reginaldo Vicente; Mariano, Daniel Botelho; Arunachalam, Karuppusamy; Soares, Ilsamar Mendes; Aguiar, Raimundo Wagner de Souza; Ascêncio, Sérgio Donizeti; Ribeiro, Marlon; Colodel, Edson Moleta; Martins, Domingos Tabajara de Oliveira

doi:10.1016/j.bjp.2019.05.002

Cited by 5 publications

(2 citation statements)

References 24 publications

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“…The WHO (2019) encouraged member countries to adopt national policies tailored to their specific situations, taking into account that the most frequent type of traditional medication with the usage of medicinal plants around the world. Prior to human use, toxicological evaluations of herbal medicines and dose validation standards are needed to evaluate and understand the associated toxic effects (Ribeiro et al, 2019). Therefore, in order to ensure that medicinal herbs are safe for regular usage, they must be thoroughly tested for toxicity.…”

Section: Introductionmentioning

confidence: 99%

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2023

Pak. J. Pharm. Sci.,

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Canarium strictum Roxb. (Burseraceae) is a tree distributed in India, China and Thailand. In traditional Ayurvedic medicine, it is used to treat asthma, rheumatism, blood impurities, syphilis, fever, epilepsy and cough. Toxicological information is currently unavailable warrants present research. Ethanol leaf extract obtained by soxhlet extraction was used to investigate its toxicity. The acute toxicity data showed ethanolic leaf extract is safe up to 2000mg/kg dose in female albino mice. There were no behavioral or physiological alterations or gross clinical abnormalities. The ethanolic leaf extract was administered orally to Wistar rats (n=5) of both sexes at a dose of 300, 600 and 1200mg/kg/d for 90 days during the investigation of sub-chronic toxicity. There were no treatment-related deleterious effects on general behavior, body weight, relative organ weight, biochemical and hematological parameters in the sub-chronic trial when evaluated daily/weekly. Organ histopathology revealed no significant abnormalities. Additionally, the ethanolic leaf extract improved rats' cholesterol and metabolic profiles. There is no apparent harm with ethanolic leaf extract treatment for 13 weeks, unless the dosage is quite high. Thus, it implies that the leaves are safer to use as a traditional medicine remedy for a variety of conditions in a wide dose range.

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Section: Introductionmentioning

confidence: 99%

Untitled

2023

Pak. J. Pharm. Sci.,

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“…Simões is an endemic species from the Brazilian semiarid region, occurring in the states of Pernambuco and Paraíba [4], there are no studies regarding their chemical composition or pharmacological activities [4]. Rich in flavonoids, steroids, and pregnane glycosides Mandevilla species have been used by folk medicine in therapy for snakebites, wound healing, and to treat skin infections and inflammation [5][6][7][8][9][10].…”

Section: Introductionmentioning

confidence: 99%

New Pregnane Glycosides from Mandevilla dardanoi and Their Anti-Inflammatory Activity

et al. 2022

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Mandevilla Lindl. is an important genus of the Apocynaceae family, not only as ornamental plants but also for its medicinal uses. In Brazil, Mandevilla species are indicated to treat asthma and skin infections, their anti-inflammatory potential and wound healing properties are also reported in the literature. Concerning their chemical composition, this group of plants is a conspicuous producer of pregnane glycosides. Mandevilla dardanoi is an endemic species from the Brazilian semiarid region not studied by any phytochemical methods. In view of the medicinal potential of Mandevilla species, this study aimed to isolate new pregnane glycosides from M. dardanoi. To achieve this main goal, modern chromatography techniques were employed. Five new pregnane glycosides, dardanols A-E, were isolated from the roots of M. dardanoi by HPLC. Their structures were determined using extensive 1D and 2D-NMR and mass spectrometry (MSn and HRESIMS) data. The cytotoxicity and the anti-inflammatory potential of these compounds were evaluated. The first was evaluated by measuring proinflammatory cytokines and nitric oxide production by stimulated macrophages. Dardanols were able to inhibit the production of nitric oxide and reduce IL-1β and TNF-α. The current work demonstrates the chemodiversity of Brazilian semiarid species and contributes to amplifying knowledge about the biological potential of the Mandevilla genus.

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