Chemical characterization and bioactive properties of decoctions and hydroethanolic extracts of Thymus carnosus Boiss.

Martins-Gomes, Carlos; Taghouti, Meriem; Schäfer, Judith; Bunzel, Mirko; Silva, Amélia M.; Nunes, Fernando M.

doi:10.1016/j.jff.2018.02.012

Cited by 41 publications

(144 citation statements)

References 39 publications

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“…The chromatographic analysis of the polyphenolic compounds was accomplished by reversed phase (C18) high-performance liquid chromatography using an Ultimate 3000 HPLC (Dionex, Sunnyvale, California, USA), equipped with Ultimate 3000 pump and column compartment, a WPS-3000 TSL Analyt auto sampler and a PDA-100 UV-visible photodiode array detector. 48 Compound separation was achieved by gradient elution on an ACE 5 C18 column, 5 μm particle size (250 mm × 4.6 mm) (Advanced Chromatography Technologies, Aberdeen, Scotland), and the analysis conditions were set with solvent A (95:5 water : formic acid (v/v)), solvent B (methanol), and a linear gradient analysis for a total run time of 80 min used as follows: starting from 5% solvent B during 2 min, increasing to 80% solvent B over 68 min, isocratic for 8 min, decreasing to 5% solvent B over 2 min, and last isocratic for 5 min. The sample volume injected was 50 μL, the flow rate was 1.0 mL/min, and the column temperature was maintained at 30 ∘ C. The eluent was continuously monitored from 200 to 600 nm with a photodiode array detector (PDA-100, Dionex).…”

Section: Determination Of the Polyphenolic Profile Of The Olive Fruitmentioning

confidence: 99%

Olive tree physiology and chemical composition of fruits are modulated by different deficit irrigation strategies

et al. 2019

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BACKGROUND Cropping practices focusing on agronomic water use efficiency and their impact on quality parameters must be investigated to overcome constraints affecting olive groves. We evaluated the response of olive trees (Olea europaea, cv. ‘Cobrançosa’) to different water regimes: full irrigation (FI, 100% crop evapotranspiration (ETc)), and three deficit irrigation strategies (DIS) (regulated (RDI, irrigated with 80% of crop evapotranspiration (ETc) in phases I and III of fruit growth and 10% of ETc in the pit hardening stage), and two continuous sustained strategies (SDI) – a conventional SDI (27.5% of ETc), and low‐frequency irrigation adopted by the farmer (SDIAF, 21.2% of ETc). RESULTS The effects of water regimes on the plant water status, photosynthetic performance, metabolite fluctuations and fruit quality parameters were evaluated. All DIS treatments enhanced leaf tissue density; RDI and SDI generally did not affect leaf water status and maintained photosynthetic machinery working properly, and the SDIAF treatment impaired olive tree physiological indicators. The DIS treatments maintained the levels of primary metabolites in leaves, but SDIAF plants showed signs of oxidative stress. Moreover, DIS treatments led to changes in the secondary metabolism, both in leaves and in fruits, with increased total phenolic compounds, ortho‐diphenols, and flavonoid concentration, and higher total antioxidant capacity, as well higher oil content. Phenolic profiles showed the relevance of an early harvest in order to obtain higher oleuropein levels with associated higher health benefits. CONCLUSION Adequate DIS are essential for sustainable olive growing, as they enhance the competitiveness of the sector in terms of olive production and associated quality parameters. © 2019 Society of Chemical Industry

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Section: Determination Of the Polyphenolic Profile Of The Olive Fruitmentioning

confidence: 99%

Olive tree physiology and chemical composition of fruits are modulated by different deficit irrigation strategies

et al. 2019

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“…T. carnosus decoction and hydroethanolic extracts, mainly including rosmarinic acid ( 71 ) and salvianolic acid K ( 76 ), reduced the viability of three cancer cell lines MCF‐7, BT‐474 and RAW 264.7. And hydroethanolic extracts showed higher activity . The essential oil from T. citriodorus leaves had strong toxic effects on HepG2 cells with the IC 50 value 0.34 % and the induced apoptosis mechanism might be associated with the expression of NF‐ κ B .…”

Section: Biological Activitiesmentioning

confidence: 98%

“…And hydroethanolic extracts showed higher activity. [118] The essential oil from T. citriodorus leaves had strong toxic effects on HepG2 cells with the IC 50 value 0.34 % and the induced apoptosis mechanism might be associated with the expression of NF-κB. [119] The extracts from T. quinquecostatus CELAK had antitumor activities against mice transplanted S180 tumor cells and they might have some influences on immunity.…”

Section: Cytotoxic Activitymentioning

confidence: 99%

Traditional Uses, Chemical Constituents and Biological Activities of Plants from the Genus Thymus

Wang

et al. 2019

Chemistry & Biodiversity

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The genus Thymus (Lamiaceae) comprises about 214 species throughout the world, mainly found in North Africa, Europe, and temperate Asia zone. They are traditionally used as food additives and folk medicines. This review comprehensively summarizes information about traditional uses, chemical constituents, and biological activities of this genus and provides recommendations for future investigations. All information was gathered from scientific databases including Google Scholar, Sci‐Finder, Web of Science, ScienceDirect, and CNKI. Volatile oils are the most concerned constituents of this genus. Flavonoids, phenylpropanoids, tannins, organic acids, terpenoids, and phytosterols were also summarized. This genus plants possessed a variety of activities including antimicrobial, antioxidant, anti‐inflammatory, cytotoxic, analgesic, and antidiabetic. In brief, this review will be helpful to provide valuable data for explorations and create more interests towards Thymus genus in the future.

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“…The possibility to administer these natural products either as oral or as an active ingredient in topical formulations is an advantage. Over centuries, antioxidant, anti-inflammatory, anti-carcinogenic, and anti-aging properties have been attributed to plants and their components [133][134][135][136].…”

Section: Apagard®royal-sangimentioning

confidence: 99%

Nanomaterials for Skin Delivery of Cosmeceuticals and Pharmaceuticals

et al. 2020

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Skin aging is described as dermatologic changes either naturally occurring over the course of years or as the result of the exposure to environmental factors (e.g., chemical products, pollution, infrared and ultraviolet radiations). The production of collagen and elastin, the main structural proteins responsible for skin strength and elasticity, is reduced during aging, while their role in skin rejuvenation can trigger a wrinkle reversing effect. Elasticity loss, wrinkles, dry skin, and thinning are some of the signs that can be associated with skin aging. To overcome skin aging, many strategies using natural and synthetic ingredients are being developed aiming to reduce the signs of aging and/or to treat age-related skin problems (e.g., spots, hyper- or hypopigmentation). Among the different approaches in tissue regeneration, the use of nanomaterials loaded with cosmeceuticals (e.g., phytochemicals, vitamins, hyaluronic acid, and growth factors) has become an interesting alternative. Based on their bioactivities and using different nanoformulations as efficient delivery systems, several cosmeceutical and pharmaceutical products are now available on the market aiming to mitigate the signs of aged skin. This manuscript discusses the state of the art of nanomaterials commonly used for topical administration of active ingredients formulated in nanopharmaceuticals and nanocosmeceuticals for skin anti-aging.

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Chemical characterization and bioactive properties of decoctions and hydroethanolic extracts of Thymus carnosus Boiss.

Cited by 41 publications

References 39 publications

Olive tree physiology and chemical composition of fruits are modulated by different deficit irrigation strategies

Olive tree physiology and chemical composition of fruits are modulated by different deficit irrigation strategies

Traditional Uses, Chemical Constituents and Biological Activities of Plants from the Genus Thymus

Nanomaterials for Skin Delivery of Cosmeceuticals and Pharmaceuticals

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