Nanomaterials for Skin Delivery of Cosmeceuticals and Pharmaceuticals

Abstract

Skin aging is described as dermatologic changes either naturally occurring over the course of years or as the result of the exposure to environmental factors (e.g., chemical products, pollution, infrared and ultraviolet radiations). The production of collagen and elastin, the main structural proteins responsible for skin strength and elasticity, is reduced during aging, while their role in skin rejuvenation can trigger a wrinkle reversing effect. Elasticity loss, wrinkles, dry skin, and thinning are some of the signs that can be associated with skin aging. To overcome skin aging, many strategies using natural and synthetic ingredients are being developed aiming to reduce the signs of aging and/or to treat age-related skin problems (e.g., spots, hyper- or hypopigmentation). Among the different approaches in tissue regeneration, the use of nanomaterials loaded with cosmeceuticals (e.g., phytochemicals, vitamins, hyaluronic acid, and growth factors) has become an interesting alternative. Based on their bioactivities and using different nanoformulations as efficient delivery systems, several cosmeceutical and pharmaceutical products are now available on the market aiming to mitigate the signs of aged skin. This manuscript discusses the state of the art of nanomaterials commonly used for topical administration of active ingredients formulated in nanopharmaceuticals and nanocosmeceuticals for skin anti-aging.

The Synthesis Methodology of PEGylated Fe3O4@Ag Nanoparticles Supported by Their Physicochemical Evaluation

“…Nanomaterials find applications in such areas as food packaging [ 2 ], the electric industry [ 3 , 4 ], or catalysts [ 5 , 6 ]. Nonetheless, particular interest in nano-sized materials is currently observed in medicine and the related areas, i.e., in orthopedy [ 7 ], dentistry [ 8 , 9 ], or in drug delivery [ 10 , 11 , 12 ].…”

Factors Affecting the Retention Efficiency and Physicochemical Properties of Spray Dried Lipid Nanoparticles Loaded with Lippia sidoides Essential Oil

“…Encapsulation into lipid nanoparticles is receiving significant attention in the pharmaceutical and food sectors, as they offer several advantages, namely their biocompatibility, biodegradability and low toxicity, the possibility to encapsulate hydrophilic and lipophilic compounds, low production costs and easy scale-up [19][20][21][22][23]. Lipid nanoparticles are classified into different types produced by very different lipids and by different methods [24,25]. Among them, nanostructured lipid carriers (NLCs) receive special attention as, due to their solid matrix, they exhibit modified release profile and site-specific targeted delivery [26,27].…”

Properties, Extraction Methods, and Delivery Systems for Curcumin as a Natural Source of Beneficial Health Effects

“…In order to enhance the bioavailability and solubility of curcumin, nanoparticles (NPs), as a colloidal delivery systems, have been used for a few years [ 70 , 71 ] in line with the development of nanotechnologies [ 72 , 73 ] and emerging applications on the nutraceutical area [ 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 ]. There are diverse types of nanocarriers that have been used to deliver curcumin (synthetic and biological) for the treatment of advanced diseases, such as cancer and neurodegenerative disorders [ 84 ].…”