Chemical characteristics, antioxidant capacities and hepatoprotection of polysaccharides from pomegranate peel

Zhai, Xichuan; Zhu, Caiping; Yang, Zhou; Sun, Jingru; Alim, Aamina; Yang, Xingbin

doi:10.1016/j.carbpol.2018.09.013

Cited by 44 publications

(18 citation statements)

References 38 publications

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“…Effect References fruit ↓of progression of cognitive and behavioral impairments in Alzheimer's disease [65] whole fruit extract anti-inflammatory and antioxidant effects [66] whole fruit extract ↓apoptosis and inflammation in liver cells [67] peel polysaccharide ↓weight loss and ↑immune organ index of immunosuppressed mice [68] peel polysaccharide protection against CCl 4 -induced liver injury [69] pomegranate aril extract inhibition of contact hypersensitivity of allergic dermatitis [70] juice ↑hypoxia-induced fetal growth and ↓apoptosis in the placenta in pregnant mice [71] juice neuroprotection and protection against oxidative damage in Parkinson's disease rat model [72] juice antileishmanial activity, probably by boosting the endogenous antioxidant activity in female BALB/c mice [73] leaf ↓total serum cholesterol and triglycerides of hyperlipidemic mice [74] peel extract contribution in prevention and treatment of Giardia lamblia infection [75] peel extract preventing bone loss associated with ovariectomy in mice [48] 3.2.1. Obesity, Diabetes…”

Section: Derivativementioning

confidence: 99%

“…Another important product of the pomegranate with several health benefits is the pomegranate peel polysaccharides (rhamnose, glucuronic acid, galacturonic acid, glucose and xylose), which may be used in efficacious adjacent immunopotentiating therapy or an alternative means in lessening chemotherapy-induced immunosuppression; they can also be utilized as immunostimulants for the food and pharmaceutical industries [68]. Several studies have shown that pomegranate peel polysaccharides may enhance the immunomodulatory effect, induced by cyclophosphamide, of immunosuppressed mice [68], exhibit a strong protective effects against CCl 4 -induced liver injury in mice [69], and, at low doses, alleviate contact hypersensitivity symptoms, suggesting that they may provide beneficial effects on allergic contact dermatitis at physiologically relevant doses in humans [70].…”

Section: Other Health Benefitsmentioning

confidence: 99%

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Food Applications and Potential Health Benefits of Pomegranate and its Derivatives

Kandylis

Kokkinomagoulos

2020

Foods

162

112

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Pomegranate (Punica granatum L.) is an ancient fruit that is particularly cultivated in west Asia, though it is also cultivated in the Mediterranean region and other parts of the world. Since ancient years, its consumption has been associated with numerous health benefits. In recent years, several in vitro and in vivo studies have revealed its beneficial physiological activities, especially its antioxidative, antimicrobial and anti-inflammatory properties. Furthermore, human-based studies have shown promising results and have indicated pomegranate potential as a protective agent of several diseases. Following that trend and the food industry’s demand for antioxidants and antimicrobials from natural sources, the application of pomegranate and its extracts (mainly as antioxidants and antimicrobials), has been studied extensively in different types of food products with satisfactory results. This review aims to present all the recent studies and trends in the applications of pomegranate in the food industry and how these trends have affected product’s physicochemical characteristics and shelf-life. In addition, recent in vitro and in vivo studies are presented in order to reveal pomegranate’s potential in the treatment of several diseases.

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Section: Derivativementioning

confidence: 99%

Section: Other Health Benefitsmentioning

confidence: 99%

Food Applications and Potential Health Benefits of Pomegranate and its Derivatives

Kandylis

Kokkinomagoulos

2020

Foods

162

112

View full text Add to dashboard Cite

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“…A great number of antioxidants have drawn considerable attention as promising beneficial supplements to eliminate alcohol-induced liver injury in animal models [9]. Dozens of natural polysaccharides have been described to have substantial hepatoprotective activities against alcohol-induced liver injury [10,11,12,13].…”

Section: Introductionmentioning

confidence: 99%

Optimization of Ultrasonic-Microwave Assisted Extraction and Hepatoprotective Activities of Polysaccharides from Trametes orientalis

et al. 2019

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Ultrasonic-microwave assisted extraction (UMAE) of Trametes orientalis polysaccharides was optimized by response surface methodology. Hepatoprotective effects of a purified T. orientalis polysaccharide (TOP-2) were evaluated by alcohol-induced liver injury model mice. The optimal UMAE parameters were indicated as below: ratio of water to raw material 28 mL/g, microwave power 114 W, extraction time 11 min. The polysaccharides yield was 7.52 ± 0.12%, which was well consistent with the predicted value of 7.54%. Pre-treatment with TOP-2 effectively increased the liver index and spleen index in alcohol-treated mice. The elevated serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels of mice after alcohol exposure were inhibited by TOP-2 administration. The liver tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β) levels have decreased significantly as a result of alcohol exposure, while pre-treatment with TOP-2 could mitigate these consequences. Furthermore, pre-treatment with TOP-2 could efficiently boost the superoxidase dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px) activities, and observably constrain the malondialdehyde (MDA) level. The findings suggest that TOP-2 might be useful for alleviating the alcohol-induced hepatotoxicity via its antioxidant and anti-inflammatory potential.

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“…27 Our results indicate more phenolic compounds in PPE in compared with PSE that is in the accordance with findings of Russo et al and Zhai et al (2018). 10,12 Russo et al observed differences in phenolic compound profiles among the different pomegranate parts and also varieties. In their study, pomegranate peel samples showed a high concentration of phenolic compounds with respect to pulp and juice samples for each variety.…”

Section: Discussionmentioning

confidence: 99%

“…9 The main benefits of pomegranate are attributed to the unique composition of polyphenols, and it exhibits high anti-inflammatory, antiproliferative, anti-hypertensive, anti-invasive, antimetastatic, and apoptotic properties and antioxidant capacities. 8,10,11 Russo et al (2018) found thirty-five phenolic compounds belonging to different classes in different pomegranate parts by high-performance liquid chromatography coupled with photodiode array and mass spectrometry detection. Twenty-eight of them were in four different phenolic compound classes including anthocyanins, phenolic acids, hydrolyzable tannins, and flavonoids.…”

Section: Introductionmentioning

confidence: 99%

Effects of Pomegranate Seed and Peel Methanolic Extracts on Methotrexate-Induced Hepatotoxicity in Rats

et al. 2019

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Background: Hepatotoxicity—the most important side effect of the Methotrexate (MTX)—seems to relate to the generation of reactive oxygen species. Pomegranate has high anti-oxidant capacities. We studied if MTX-induced hepatotoxicity can be protected by pomegranate peel and seed methanolic extracts (PPE and PSE) in rats. Methods: Forty-eight Wistar rats were divided on the basis of: orally received normal saline as control, orally received 500 mg/kg PSE, orally received 500 mg/kg PPE, intramuscularly (IM) received 10 mg/kg MTX, MTX- and PSE-received, and MTX- and PPE-received groups. After the intervention, blood and liver samples were obtained. Results: The results showed considerable antioxidant activity (510.7 ± 2.5 µg/ml) and total phenolic content (147.2 ± 0.2 mg GAE/g extract) of PSE and PPE, respectively. The ALT value reached the levels of the control group after treatment with PSE in PSE + MTX group. The serum level of ALT showed a significant increase in PPE+MTX group in comparison with MTX group. The results indicated that the PSE and PPE did not have considerable effect on ALP levels alone or together with MTX. Our results showed that PSE+ MTX and also PPE+ MTX treatment caused serum AST values to increase significantly in comparison with control and MTX groups. In histopatological study, the extracts decreased the pathological changes induced by methotrexate. Conclusion: The present study demonstrated that PPE and PSE that have notable total flavonoid and phenolic contents and also antioxidant activity, can protect the liver against histo-pathological and some enzymatic changes induced by MTX in rats.

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Chemical characteristics, antioxidant capacities and hepatoprotection of polysaccharides from pomegranate peel

Cited by 44 publications

References 38 publications

Food Applications and Potential Health Benefits of Pomegranate and its Derivatives

Food Applications and Potential Health Benefits of Pomegranate and its Derivatives

Optimization of Ultrasonic-Microwave Assisted Extraction and Hepatoprotective Activities of Polysaccharides from Trametes orientalis

Effects of Pomegranate Seed and Peel Methanolic Extracts on Methotrexate-Induced Hepatotoxicity in Rats

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