Chemical and thermal cross-linking of collagen and elastin hydrolysates

Properties and modification of porous 3-D collagen/hydroxyapatite composites

“…Many attempts have been made to overcome this problem through the means of mixing collagen with either natural (e.g. elastin [11,12], chitosan [10,12], glycoaminoglycans -GAGs [13,14]) or synthetic polymers (e.g. poly(vinyl alcohol) -PVA [15], polycaprolactone -PCL [6,16], polylactic acid -PLLA [6], polyglycolic acid -PGA [6,17]) or by adding mineral crystals [18,19].…”

Fabrication of three-dimensional collagen scaffold using an inverse mould-leaching process

“…4b, the positions of peaks before and after cross-linked collagen are located in the completely same points, but the area of the IR bands for cross-linked collagen is much smaller compared to uncross-linked collagen. According to Sinokowska et al [26], the position of IR spectra for the collagen cross-liked with EDC could be same with the uncross-linked collagen because the secondary structure of collagen is not destroyed. Also, the coupled area of amide A and OH band (3,700-3,100 cm -1 ) is much smaller for cross-linked collagen because crosslinked collagen loses water bonded to the collagen [26].…”

“…According to Sinokowska et al [26], the position of IR spectra for the collagen cross-liked with EDC could be same with the uncross-linked collagen because the secondary structure of collagen is not destroyed. Also, the coupled area of amide A and OH band (3,700-3,100 cm -1 ) is much smaller for cross-linked collagen because crosslinked collagen loses water bonded to the collagen [26]. From these IR spectra, the collagen was sufficiently crosslinked in the EDC solution.…”

Biodegradable polymers for dental tissue engineering and regeneration

“…In fact, it is used as suture material in surgery [304], as depot delivery device in the local extended release of antibiotics [305], DNA [306], siRNA [307], and proteins [308] and as haemostatic sealant [309]. In tissue engineering, collagen sponges are widely diffused due to their ability to withstand high tensile loads (92.5 MPa ultimate tensile strength) [310]. Other applications of collagen relate to reconstructive skin surgery and tissue engineering scaffold for cartilage, tendon, and ligament [311].…”