Chemical and physical parameters of tears relevant for the design of ocular drug delivery formulations

Baeyens, Vincent; Gurny, Robert

doi:10.1016/s0031-6865(97)00021-6

Cited by 68 publications

(34 citation statements)

References 67 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…These conditions allow pH-sensitive hydrogels to release the desired drug in the right place [17]. In case of ophthalmologic therapies the release should be close to the medium ocular pH of 7.45 [18,19].…”

mentioning

confidence: 99%

Evaluation of pH-sensitive poly(2-hydroxyethyl methacrylate-co-2-(diisopropylamino)ethyl methacrylate) copolymers as drug delivery systems for potential applications in ophthalmic therapies/ocular delivery of drugs

Faccia¹,

Pardini²,

Amalvy³

2015

Express Polym. Lett.

View full text Add to dashboard Cite

mentioning

confidence: 99%

Evaluation of pH-sensitive poly(2-hydroxyethyl methacrylate-co-2-(diisopropylamino)ethyl methacrylate) copolymers as drug delivery systems for potential applications in ophthalmic therapies/ocular delivery of drugs

Faccia¹,

Pardini²,

Amalvy³

2015

Express Polym. Lett.

View full text Add to dashboard Cite

“…Mucoadhesion, on the other hand, is promoted by the presence of positive charge groups. 52 Our results show that PLGA-rMOMP was stable and had a negative surface charge of −14.30 mV, which may be attributed to the addition of polyvinyl alcohol to the suspension. A study by Kumar et al 53 showed that particles made with polyvinyl alcohol alone were negatively charged and those made with a blend of polyvinyl alcohol-chitosan were more positively charged.…”

Section: Discussionmentioning

confidence: 67%

“…Another concern regarding nanoparticle formulations is the value of the zeta potential, which is important for understanding and predicting the long-term stability and mucoadhesion of nanoparticles. 52 In theory, the more negative or positive the zeta potential, the more stable the nanoparticle suspension. Mucoadhesion, on the other hand, is promoted by the presence of positive charge groups.…”

Section: Discussionmentioning

confidence: 99%

Chlamydia trachomatis recombinant MOMP encapsulated in PLGA nanoparticles triggers primarily T helper 1 cellular and antibody immune responses in mice: a desirable candidate nanovaccine

Fairley¹,

Singh²,

Yilma³

et al. 2013

IJN

View full text Add to dashboard Cite

Abstract:We recently demonstrated by in vitro experiments that PLGA (poly D, L-lactideco-glycolide) potentiates T helper 1 (Th1) immune responses induced by a peptide derived from the recombinant major outer membrane protein (rMOMP) of Chlamydia trachomatis, and may be a promising vaccine delivery system. Herein we evaluated the immune-potentiating potential of PLGA by encapsulating the full-length rMOMP (PLGA-rMOMP), characterizing it in vitro, and investigating its immunogenicity in vivo. Our hypothesis was that PLGA-rMOMP triggers Th1 immune responses in mice, which are desirable prerequisites for a C. trachomatis candidate nanovaccine. Physical-structural characterizations of PLGA-rMOMP revealed its size (approximately 272 nm), zeta potential (−14.30 mV), apparent spherical smooth morphology, and continuous slow release pattern. PLGA potentiated the ability of encapsulated rMOMP to trigger production of cytokines and chemokines by mouse J774 macrophages. Flow cytometric analyses revealed that spleen cells from BALB/c mice immunized with PLGA-rMOMP had elevated numbers of CD4+ and CD8+ T cell subsets, and secreted more rMOMP-specific interferon-gamma (Th1) and interleukin (IL)-12p40 (Th1/Th17) than IL-4 and IL-10 (Th2) cytokines. PLGA-rMOMP-immunized mice produced higher serum immunoglobulin (Ig)G and IgG2a (Th1) than IgG1 (Th2) rMOMP-specific antibodies. Notably, sera from PLGA-rMOMPimmunized mice had a 64-fold higher Th1 than Th2 antibody titer, whereas mice immunized with rMOMP in Freund's adjuvant had only a four-fold higher Th1 than Th2 antibody titer, suggesting primarily induction of a Th1 antibody response in PLGA-rMOMP-immunized mice. Our data underscore PLGA as an effective delivery system for a C. trachomatis vaccine. The capacity of PLGA-rMOMP to trigger primarily Th1 immune responses in mice promotes it as a highly desirable candidate nanovaccine against C. trachomatis.

show abstract

“…Nanoparticulates also help in achieving the most important feature of ocular drug delivery that is equal bioavailability due to their reduced size [19]. Moreover, nanoparticulates are not easily removed from the ocular area because of blinking or tear mechanism as compared to free drug [16,20]. …”

Section: Introductionmentioning

confidence: 99%

An approach to revolutionize cataract treatment by enhancing drug probing through intraocular cell line

Liu

Huang

2018

Libyan Journal of Medicine

View full text Add to dashboard Cite

The purpose of this study is to prepare and characterize solid lipid nanoparticles (SLN) of N-Acetyl Carnosine (NAC) to treat cataract since surgery necessitates equipments and professional help. Cataract is believed to be formed by the biochemical approach where the crystalline eye proteins lose solubility and forms high molecular weight masses. Added advantages of SLN of NAC (henceforth referred as SLN-NAC) in the study are reduced size, sustained release and better corneal penetration of drug. The method of preparation of SLN-NAC by Mill’s method is unique in itself.The size of the SLN-NAC was 75 ± 10 nm in the range of ideal for penetration. The in-vitro release study and the SLN-NAC formulations prepared with Mill’s method demonstrated sustained release up to 24 h following an initial burst after 1 h. The zeta potential of the prepared formulation was −22.1 ± 1 mV. Corneal permeation studies using goat corneas indicate that SLN-NAC penetration rate was higher than those from NAC eye drops. Corneal hydration studies indicated that the formulation caused no harm to the corneal cells.Therefore it may be concluded that SLN-NAC may revolutionize cataract treatment and reversal by improving drug permeation, reducing toxicity and no damage to corneal tissue.

show abstract

Chemical and physical parameters of tears relevant for the design of ocular drug delivery formulations

Cited by 68 publications

References 67 publications

Evaluation of pH-sensitive poly(2-hydroxyethyl methacrylate-co-2-(diisopropylamino)ethyl methacrylate) copolymers as drug delivery systems for potential applications in ophthalmic therapies/ocular delivery of drugs

Evaluation of pH-sensitive poly(2-hydroxyethyl methacrylate-co-2-(diisopropylamino)ethyl methacrylate) copolymers as drug delivery systems for potential applications in ophthalmic therapies/ocular delivery of drugs

Chlamydia trachomatis recombinant MOMP encapsulated in PLGA nanoparticles triggers primarily T helper 1 cellular and antibody immune responses in mice: a desirable candidate nanovaccine

An approach to revolutionize cataract treatment by enhancing drug probing through intraocular cell line

Contact Info

Product

Resources

About