An approach to revolutionize cataract treatment by enhancing drug probing through intraocular cell line

Abstract

The purpose of this study is to prepare and characterize solid lipid nanoparticles (SLN) of N-Acetyl Carnosine (NAC) to treat cataract since surgery necessitates equipments and professional help. Cataract is believed to be formed by the biochemical approach where the crystalline eye proteins lose solubility and forms high molecular weight masses. Added advantages of SLN of NAC (henceforth referred as SLN-NAC) in the study are reduced size, sustained release and better corneal penetration of drug. The method of preparation of SLN-NAC by Mill’s method is unique in itself.The size of the SLN-NAC was 75 ± 10 nm in the range of ideal for penetration. The in-vitro release study and the SLN-NAC formulations prepared with Mill’s method demonstrated sustained release up to 24 h following an initial burst after 1 h. The zeta potential of the prepared formulation was −22.1 ± 1 mV. Corneal permeation studies using goat corneas indicate that SLN-NAC penetration rate was higher than those from NAC eye drops. Corneal hydration studies indicated that the formulation caused no harm to the corneal cells.Therefore it may be concluded that SLN-NAC may revolutionize cataract treatment and reversal by improving drug permeation, reducing toxicity and no damage to corneal tissue.

Breaking Barriers: Nanomedicine-Based Drug Delivery for Cataract Treatment

“…27 However, the transformation also impedes the diffusion-dependent transportation of antioxidants to the lens center. Both LCS and NACS can also be incorporated into lipid-based carriers 70,71 and gold nanoparticles (AuNPs) 72 to enhance their efficacious corneal penetration and accumulating antioxidants in nuclear fiber cells. By carefully designing prodrugs, the release and distribution of the drug in the eye can be better controlled, resulting in prolonged intraocular retention time, increased corneal permeability and significantly improved bioavailability.…”

“…This suggests that SLN-NAC has the potential to revolutionize cataract treatment by enhancing drug permeation, reducing toxicity, and avoiding damage to corneal tissue. 71 Penetration enhancers, such as cyclodextrins, can temporarily increase the https://doi.org/10.2147/IJN.S463679…”

Recent Progress of Solid Lipid Nanoparticles and Nanostructured Lipid Carriers as Ocular Drug Delivery Platforms

“…Various nanoscale drug delivery systems, such as liposomes [ 22 , 23 ], niosomes [ 24 , 25 ], solid lipid/polymeric nanoparticles [ 26 , 27 , 28 , 29 ], nanostructured lipid carriers [ 30 , 31 ], nanomicelles [ 32 , 33 ], microemulsions [ 34 , 35 ], and dendrimers [ 36 ], have been successfully developed for ocular delivery purposes, and have been reported to achieve enhanced bioavailability, sustained and controlled drug release, and a reduction in the number of applications, as well as side effects. SLNs and NLCs raise great interest due to their excellent biocompatibility and tolerability, tunable physiochemical characteristics, and scaling-up capabilities [ 37 , 38 , 39 ].…”