2021
DOI: 10.3390/nano11071776
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Chemical and Physical Characterisation of Human Serum Albumin Nanocolloids: Kinetics, Strength and Specificity of Bonds with 99mTc and 68Ga

Abstract: Nanoparticles of Human Serum Albumin (NC) labelled with 99mTc are widely used in Nuclear Medicine and represent the gold-standard for the intraoperative detection of the sentinel lymph node in many kinds of cancer, mainly breast cancer and melanoma. A significant amount of radionuclides can be incorporated into the HSA particle, due to the multiple binding sites, and HSA-based nanocolloid catabolism is a fast and easy process that results in innocuous degradation products. NCs labelled with different isotopes … Show more

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Cited by 7 publications
(12 citation statements)
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References 21 publications
(28 reference statements)
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“…It was then normalised to the number of human serum albumin molecules forming a single MAA particle, obtaining (8.29(2) 1 × 10 −5 ), which is even lower than that of HSA (about 1 atom/10,000 tightly bound) at SPC condition. A value sharply different from NC (46.4(2)) and from human serum albumin forming a single NC particle (2.1(2)) was observed [23].…”
Section: Discussionmentioning
confidence: 91%
See 2 more Smart Citations
“…It was then normalised to the number of human serum albumin molecules forming a single MAA particle, obtaining (8.29(2) 1 × 10 −5 ), which is even lower than that of HSA (about 1 atom/10,000 tightly bound) at SPC condition. A value sharply different from NC (46.4(2)) and from human serum albumin forming a single NC particle (2.1(2)) was observed [23].…”
Section: Discussionmentioning
confidence: 91%
“…To characterise the bond characteristic between isotopes and MAA, an attempt was made to evaluate the kinetics of radiolabelling of MAA with 99m Tc. The speed of radiolabelling was too rapid to detect the variation of MAA labelled (95% labelling in less than 60 s); it should be noted that the speed increase from HSA to NC [23] to MAA is probably due to the greater reaction surface.…”
Section: Discussionmentioning
confidence: 95%
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“…Smaller, 50–80 nm HSA nanoparticles labelled with 99m Tc provide a diagnostic radiopharmaceutical agent for sentinel lymph nodes scintigraphy (Giammarile et al 2013 ; Sadkin et al 2020 ). Several commercially available kit formulations for preparing [ 99m Tc]Tc-HSA nanocolloid have become available recently and are described in the literature (Nanotop®, Nanoalbumon®, Nanocoll®) (Persico et al 2015 ; Gommans et al 2009 ; Marenco et al 2021 ). Since the radiopharmaceutical is prepared shortly prior to administration, a quality control (QC) must be performed immediately after radiolabelling in order to determine the radiochemical purity (RCP).…”
Section: Introductionmentioning
confidence: 99%
“…The SPC of Nanoalbumon® (Medi-Radiopharma Ltd, Erd, Hungary) stipulates 85% aqueous methanol mobile phase with iTLC-SG or Whatman No. 1 for determining the RCP (Marenco et al 2021 ). The United States Pharmacopoeia includes a monograph on [ 99m Tc]Tc-albumin colloid injection, giving a method for determining RCP using iTLC-SG with methyl ethyl ketone (United States Pharmacopoeia Convention.…”
Section: Introductionmentioning
confidence: 99%