Chemical and Pharmacological Studies of the Plants from Genus <i>Celastrus</i>

Su, Xiao Hui; Zhang, Man Li; Zhan, Wen Hong; Huo, Chang Hong; Shi, Qing; Gu, Yu‐Cheng; Kiyota, Hiromasa

doi:10.1002/cbdv.200700403

Cited by 36 publications

(14 citation statements)

References 54 publications

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“…2). NOESY Correlations observed between Me(15) and HÀC (2) and Me (14), and the large coupling constant (J 1,2 ¼ 10.4 Hz) between HÀC(1) and HÀC(2) of 5 suggested that the configurations of AcOÀC(2) and MeÀC(10) were b and a, respectively. Accordingly, we characterized compound 5 as (1a,2b,8b,9b)-1,2,8-tris(acetyloxy)-9-(benzoyloxy)dihydro-b-agarofuran.…”

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confidence: 92%

“…-Celastrus paniculatus (Celastraceae) is an evergreen shrub distributed throughout Hengchun peninsula of Taiwan, India, and Malaysia [1]. The family Celastraceae is well known for producing dihydroagarofuran derivatives and alkaloids [2], some of which exhibit insecticidal [3], antitumor [4] [5], anti-inflammatory [6], multidrug-resistance (MDR) reversing [7] [8], and immunosuppressive [9] activities. Moreover, seed oil of C. paniculatus has been reported to improve memory [10] and intestinal complaints [11] [12], and display antioxidant [13], and hypolipidemic [14] effects.…”

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confidence: 99%

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New Dihydroagarofuranoid Sesquiterpenes from Celastrus paniculatus

Weng

Yen

2010

Helvetica Chimica Acta

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The six new dihydro-b-agarofuranoid sesquiterpenes 1 -6 and three known compounds were isolated from the whole plant of Celastrus paniculatus. The structures including relative configurations were elucidated by means of spectroscopic analyses. Compounds 1 -6 were evaluated for cytotoxicity against a panel of three human-tumor cell lines.Introduction. 14] effects. In our preliminary cytotoxicity screening for the genus Celastrus in Taiwan, the whole plant extract of C. paniculatus showed in vitro activity. In this article, we report the isolation and structural elucidation of the six new sesquiterpenes 1 -6 1 ) and of three known compounds, including a dihydro-b-agarofuranoid sesquiterpene,

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confidence: 92%

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confidence: 99%

New Dihydroagarofuranoid Sesquiterpenes from Celastrus paniculatus

Weng

Yen

2010

Helvetica Chimica Acta

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“…With regard to other plant extracts, sesquiterpenes from Aquilaria spp. and extracts from plants of the genus Celastrus were also found to reduce joint pain [30, 31]. …”

Section: Resultsmentioning

confidence: 99%

A Pilot Study on Bioactive Constituents and Analgesic Effects of MyrLiq®, a Commiphora myrrha Extract with a High Furanodiene Content

Germanò¹,

Occhipinti

Maffei

2017

BioMed Research International

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The analgesic properties of myrrh (Commiphora myrrha) have been known since ancient times and depend on the presence of bioactive sesquiterpenes with furanodiene skeletons. MyrLiq is a C. myrrha extract with a standardized content of curzerene, furanoeudesma-1,3-diene, and lindestrene (12.31 ± 0.05 g kg−1, 18.84 ± 0.02 g kg−1, and 6.23 ± 0.01 g kg−1, resp.) and a high total furanodiene content (40.86 ± 0.78 g kg−1). A balanced sample of 95 female and 89 male volunteers (with ages ranging from 18 to older than 60 years) exhibiting different pain pathologies, including headache, fever-dependent pain, joint pain, muscle aches, lower back pain, and menstrual cramps, was divided into two groups. The experimental group received 1 capsule/day containing either 200 mg or 400 mg of MyrLiq (corresponding to 8 mg and 16 mg of bioactive furanodienes, resp.) for 20 days, and the placebo group was given the same number of capsules with no MyrLiq. A score was recorded for all volunteers based on their previous experience with prescribed analgesics. For the male volunteers, pain alleviation was obtained with 400 mg of MyrLiq/day for almost all pathologies, whereas, for female volunteers, alleviation of lower back pain and fever-dependent pain was observed with only 200 mg of MyrLiq/day. These results indicate that MyrLiq has significant analgesic properties.

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“…The extracts of this plant has been used for years in Chinese traditional medicine for its anti-inflammatory properties ( Tao and Lipsky, 2000 ; Kannaiyan et al, 2011a , b , c ). Recently there has been a tremendous increase in the interest about the potential anticancer properties of CSL ( Su et al, 2009 ; Shanmugam et al, 2016 ). It has been reported to display anti-inflammatory and anti-neoplastic effects in various tumor cells including MM via modulation of diverse oncogenic molecular targets ( Kannaiyan et al, 2011a , c ).…”

Section: Introductionmentioning

confidence: 99%

Celastrol Attenuates the Invasion and Migration and Augments the Anticancer Effects of Bortezomib in a Xenograft Mouse Model of Multiple Myeloma

et al. 2018

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Several lines of evidence have demonstrated that deregulated activation of NF-κB plays a pivotal role in the initiation and progression of a variety of cancers including multiple myeloma (MM). Therefore, novel molecules that can effectively suppress deregulated NF-κB upregulation can potentially reduce MM growth. In this study, the effect of celastrol (CSL) on patient derived CD138+ MM cell proliferation, apoptosis, cell invasion, and migration was investigated. In addition, we studied whether CSL can potentiate the apoptotic effect of bortezomib, a proteasome inhibitor in MM cells and in a xenograft mouse model. We found that CSL significantly reduced cell proliferation and enhanced apoptosis when used in combination with bortezomib and upregulated caspase-3 in these cells. CSL also inhibited invasion and migration of MM cells through the suppression of constitutive NF-κB activation and expression of downstream gene products such as CXCR4 and MMP-9. Moreover, CSL when administered either alone or in combination with bortezomib inhibited MM tumor growth and decreased serum IL-6 and TNF-α levels. Overall, our results suggest that CSL can abrogate MM growth both in vitro and in vivo and may serve as a useful pharmacological agent for the treatment of myeloma and other hematological malignancies.

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Chemical and Pharmacological Studies of the Plants from Genus Celastrus

Cited by 36 publications

References 54 publications

New Dihydroagarofuranoid Sesquiterpenes from Celastrus paniculatus

New Dihydroagarofuranoid Sesquiterpenes from Celastrus paniculatus

A Pilot Study on Bioactive Constituents and Analgesic Effects of MyrLiq®, a Commiphora myrrha Extract with a High Furanodiene Content

Celastrol Attenuates the Invasion and Migration and Augments the Anticancer Effects of Bortezomib in a Xenograft Mouse Model of Multiple Myeloma

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