Chemical and microstructural characterization of natural hydroxyapatite derived from pig bones

Janus, Anna Maria; Faryna, M.; Haberko, Krzysztof; Rakowska, A.; Panz, Tomasz

doi:10.1007/s00604-007-0864-2

Cited by 77 publications

(58 citation statements)

References 13 publications

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“…Both chemical and thermal approaches have been used to prepare biological HA derived from animal bones 14,24,30,31) . Thermal treatment has several advantages: it is the only means to eliminate organic matter 32) and it decreases the risk of disease transmission and immunoreactivity 30) .…”

Section: Synthesis Of Fluorinated Phamentioning

confidence: 99%

Preparation and characterization of fluorinated porcine hydroxyapatite

Liu

Chen

et al. 2012

Dent. Mater. J.

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Simple chemical and thermal treatments were applied to prepare fluorinated porcine hydroxyapatite (FPHA). Morphology of FPHA was observed using SEM. Physiochemical characteristics, namely crystalline phase, chemical composition, functional groups, and binding energy of fluorine were investigated using XRD, EDX, FTIR, and XPS respectively. Concentration of free fluoride ion released from FPHA in HCl solution (pH 3.0-4.0) was detected using a fluoride ion concentration meter. SEM, XPS, XRD, and FTIR results confirmed the fluorination of porcine hydroxyapatite (PHA). Significant crystal morphological difference was observed between PHA and FPHA. Concentration of free fluoride ion released from FPHA increased with rising concentration of immersion solution and length of immersion period. Fluoride was successfully incorporated into PHA by chemical and thermal processes in this study. Fluoride incorporation rate into PHA was a strong function of the fluorine concentration in the immersion solution.

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Section: Synthesis Of Fluorinated Phamentioning

confidence: 99%

Preparation and characterization of fluorinated porcine hydroxyapatite

Liu

Chen

et al. 2012

Dent. Mater. J.

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“…At sintering, the gases move towards the outside of powders and green bodies shrink owing to decrease of distances among the particles. For example, sintering of a biologically formed apatites was investigated [252,253] and the obtained products were characterized [254,255]. In all cases, the numerical value of Ca/P ratio in sintered apatites of biological origin was higher than that of the stoichiometric HA.…”

Section: Sintering and Firingmentioning

confidence: 99%

Medical Application of Calcium Orthophosphate Bioceramics

Dorozhkin¹

2011

BIO

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In the late 1960's, a strong interest was raised in biomedical applications of ceramic materials (named bioceramics a little bit later). Bioceramics was initially used as reasonable alternatives to metals in order to increase their biocompatibility. However, within a short period, it has grown into a diverse class of biomaterials, presently including three essential types: relatively bioinert, bioactive (or surface reactive) and bioresorbable bioceramics. This review is limited to bioceramics prepared from calcium orthophosphates only, which belong to the categories of bioactive and bioresorbable compounds. There have been a number of important advances in this field during the past 30 -40 years. The research was shifted from an initial study on the develop-ment of bioinert bioceramics towards bioactive and bioresorbable bioceramics, and these different types of calcium orthophosphate bioceramics can be tuned through the structural and compositional control. At the turn of the millennium, a new concept of calcium orthophosphate bioceramics has been developed to promote a regeneration of bones. Current biomedical applications of calcium orthophosphate bioceramics include artificial replacements for hips, knees, teeth, tendons and ligaments, as well as repair for periodontal disease, maxillofacial reconstruction, augmenttation and stabilization of the jawbone, spinal fusion and bone fillers after tumor surgery. Potential future applications of calcium orthophosphate bioceramics are demonstrated in drug delivery systems, effective carriers of growth factors, bioactive peptides and/or various types of cells for tissue engineering purposes.

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“…Similar to an earlier study (Oudadesse et al 2004), our results showed Ca, P and Mg to be the main elements in the bones. Ca and P, the main components in hydroxyapatite, are known to be of at most importance (Janus et al 2008). Smaller Ca and P concentrations cause smaller hydroxyapatite content in the bones.…”

Section: Discussionmentioning

confidence: 99%

“…Smaller Ca and P concentrations cause smaller hydroxyapatite content in the bones. Although physiological differences were not found in the toe bones, decreasing hydroxyapatite content may cause more porous structure in the bones (Janus et al 2008). Zn is one of the microelements which are retained in terrestrial metamorphosis (Unrine et al 2007); thus, Zn may also be monitored in adult amphibians.…”

Section: Discussionmentioning

confidence: 99%

Assessment of the effects of urbanization on trace elements of toe bones

Simon

Puky

Braun

et al. 2011

Environ Monit Assess

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Amphibians, particularly frogs and toads, are increasingly used as bioindicators of contaminant accumulation in pollution studies. We developed an analytical technique to analyse their elemental contents based on a small amount of toe bone samples. This method is environment-friendly as, unlike traditional methods, it is not necessary to kill animals during sampling. Using this technique, we explored the effects of urbanization on the elemental contents of toe bones. Bufo bufo specimens were collected from an urban and two rural ponds. The ratios of Ca and P at the ponds were: 20.5% Ca and 14.6% P at the urban pond and 30.4% and 29.6% Ca, 22.4% and 21.7% P at the rural ponds, respectively. For the other elements, the following percentage ratios were found: 0.7% B, 0.3% Mg and 0.06% Zn at the urban pond and 1.1% and 0.4% B, 0.4% Mg and 0.05% Zn at the rural ponds, respectively. Canonical discriminant analysis indicated the separation of the urban and the rural ponds based on the elemental concentrations of toe bones. Significant differences were found between the concentrations of Ca, P, Mg, B and Zn at the urban and the rural ponds (p<0.05). Anthropogenic activity was found to have effects on the elemental contents of toe bones in the urbanized area. Our study also demonstrated that the developed method was appropriate for the elemental analysis of small samples to assess the effects of urbanization.

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Chemical and microstructural characterization of natural hydroxyapatite derived from pig bones

Cited by 77 publications

References 13 publications

Preparation and characterization of fluorinated porcine hydroxyapatite

Preparation and characterization of fluorinated porcine hydroxyapatite

Medical Application of Calcium Orthophosphate Bioceramics

Assessment of the effects of urbanization on trace elements of toe bones

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