Chemical and biological studies of <i>Ribes nigrum</i> L. buds essential oil

Oprea, Eliza; Rădulescu, Vicenţiu D.; Balotescu, Carmen; Lazăr, Veronica; Bucur, Marcela; Mladin, P.; Fărcăşanu, Ileana C.

doi:10.1002/biof.5520340102

Cited by 11 publications

(5 citation statements)

References 22 publications

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“…A decrease in blood glucose level was also observed in Group Cii (Diabetic treated with 80 mg/kg body weight of aqueous leaf extract of V. amygdalina) when compared with Groups Aii and Aiii on days (7, 14 and 21) ( Table 2). Tannin has been reported to inhibit alpha-amylase, sucrose, as well as the action of SGLUT-1 of the intestinal brush border (Tiwari and Rao, 2002) and some other enzymes (Zheng et al, 2009;Oprea et al, 2008).…”

Section: Phytochemical Analysismentioning

confidence: 99%

Anti-hyperglycaemic and anti-hyperlipidemic effect of aqueous leaf extract of Vernonia amygdalina in Wistar rats

Ibegbu¹,

Emmanuel²,

Ikele³

et al. 2018

Afr. J. Pharm. Pharmacol.

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Diabetes mellitus is a complex metabolic disorder characterised by impaired glucose tolerance and hyperglycemia, which is caused by either lack of or resistance to insulin in tissues; this disease causes significant morbidity and mortality largely due to its end-organ complications. Traditional treatment of diabetes mellitus has involved the use of several plant extracts; in this study the efficacy of aqueous leaf extract of Vernonia amygdalina (VA) was sought as a treatment module for alloxan induced diabetic rats. The aqueous leaf extract of VA was administered in three (3) different doses (40, 80 and 120 mg/kg) to non-diabetic and alloxan-induced diabetic rats. The body weights of the experimental animals were taken along with blood samples collection at baseline, on 7 th , 14 th and 21 st days; thereafter the blood glucose and serum lipid levels were determined. The aqueous leaf extract of VA showed statistical significant (p<0.05) reduction of blood glucose, serum triglyceride and cholesterol, as well as body weight in both non-diabetic and alloxan-induced diabetic rats. This study showed that aqueous leaf extract of VA administered at different doses contains anti-hyperglycemic and lipid lowering activities, with 80 mg/kg body weight dosage appearing to be the minimum effective dose; suggesting that aqueous leaf extract of VA is likely to contain actives that could be important in the control of blood glucose and serum lipid levels in diabetics.

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Section: Phytochemical Analysismentioning

confidence: 99%

Anti-hyperglycaemic and anti-hyperlipidemic effect of aqueous leaf extract of Vernonia amygdalina in Wistar rats

Ibegbu¹,

Emmanuel²,

Ikele³

et al. 2018

Afr. J. Pharm. Pharmacol.

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“…Tabart et al have reported that buds possess higher antioxidant ability than do other black currant parts. The essential oils of buds have been reported to possess significant antimicrobial activity against pathogenic bacteria . Hence, the buds could be a natural alternative for the treatment of infectious diseases.…”

Section: Introductionmentioning

confidence: 99%

“…The essential oils of buds have been reported to possess significant antimicrobial activity against pathogenic bacteria. 30 Hence, the buds could be a natural alternative for the treatment of infectious diseases.…”

Section: ■ Introductionmentioning

confidence: 99%

An Optimized Method for Analysis of Phenolic Compounds in Buds, Leaves, and Fruits of Black Currant (Ribes nigrum L.)

Vagiri

Ekholm

Andersson

et al. 2012

J. Agric. Food Chem.

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Although the fruits are the economic driver for the black currant industry, the buds and leaves are excellent sources of beneficial phenolic compounds that may contribute to the future value of the crop. In this study, extraction of phenolic compounds for different parts of the black currant plant was optimized, and an efficient method for their separation by HPLC was developed. This allowed the simultaneous quantification of a range of hydroxycinnamic acids, flavan-3-ols, flavonols, and anthocyanins by DAD following their identification by HPLC-ESI-MS(n). A total of 23 compounds were detected in the buds, 22 of which were found in fruit and leaves. To the best of our knowledge, this is the first report of flavonol glycosides of quercetin, myricetin, isorhamnetin, and kaempferol along with hydroxycinnamic acids such as neo-chlorogenic acid and chlorogenic acid in the buds. Additionally, we provide the first evidence of kaempferol-3-O-rutinoside in black currant leaves. This approach offers avenues for superior combined compositional identification and cultivar selection targeted at the generation of polyphenol-rich products derived from the whole crop and not just the fruit.

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“…EOs are mixtures of molecules such as terpenoids, phenol-derived aromatic components and aliphatic components. Their quality, quantity and composition can vary depending on plant species, subsp., growth conditions (seasonal variation, climate, phenophase at the moment of harvesting), plant organ, age and oil extraction method [ 235 ].…”

Section: Drugs As Antibiotic Alternatives or Complementsmentioning

confidence: 99%

Resistance, Tolerance, Virulence and Bacterial Pathogen Fitness—Current State and Envisioned Solutions for the Near Future

2023

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The current antibiotic crisis and the global phenomena of bacterial resistance, inherited and non-inherited, and tolerance—associated with biofilm formation—are prompting dire predictions of a post-antibiotic era in the near future. These predictions refer to increases in morbidity and mortality rates as a consequence of infections with multidrug-resistant or pandrug-resistant microbial strains. In this context, we aimed to highlight the current status of the antibiotic resistance phenomenon and the significance of bacterial virulence properties/fitness for human health and to review the main strategies alternative or complementary to antibiotic therapy, some of them being already clinically applied or in clinical trials, others only foreseen and in the research phase.

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Chemical and biological studies of Ribes nigrum L. buds essential oil

Cited by 11 publications

References 22 publications

Anti-hyperglycaemic and anti-hyperlipidemic effect of aqueous leaf extract of Vernonia amygdalina in Wistar rats

Anti-hyperglycaemic and anti-hyperlipidemic effect of aqueous leaf extract of Vernonia amygdalina in Wistar rats

An Optimized Method for Analysis of Phenolic Compounds in Buds, Leaves, and Fruits of Black Currant (Ribes nigrum L.)

Resistance, Tolerance, Virulence and Bacterial Pathogen Fitness—Current State and Envisioned Solutions for the Near Future

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