Chemical and biological metal nanoparticles as antimycobacterial agents: A comparative study

Singh, Richa; Nawale, Laxman; Arkile, Manisha; Shedbalkar, Utkarsha U.; Wadhwani, Sweety A.; Sarkar, Dhiman; Chopade, Balu A.

doi:10.1016/j.ijantimicag.2015.03.014

Cited by 95 publications

(70 citation statements)

References 25 publications

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“…Similar results were already reported for P. aeruginosa [30] and A. baumannii [31,32]. Moreover, this nanomaterial showed a similar action on the growth inhibition of multidrug-resistant bacteria presented by AgNPs synthesized by chemical and biological routes [33].…”

Section: Bacterial Strain Zone Of Inhibition (Mm) Xg 500 Mg/mlsupporting

confidence: 87%

Silver Nanocomposite Biosynthesis: Antibacterial Activity against Multidrug-Resistant Strains of Pseudomonas aeruginosa and Acinetobacter baumannii

et al. 2016

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Abstract:Bacterial resistance is an emerging public health issue that is disseminated worldwide. Silver nanocomposite can be an alternative strategy to avoid Gram-positive and Gram-negative bacteria growth, including multidrug-resistant strains. In the present study a silver nanocomposite was synthesized, using a new green chemistry process, by the addition of silver nitrate (1.10 −3 mol·L −1 ) into a fermentative medium of Xanthomonas spp. to produce a xanthan gum polymer. Transmission electron microscopy (TEM) was used to evaluate the shape and size of the silver nanoparticles obtained. The silver ions in the nanocomposite were quantified by flame atomic absorption spectrometry (FAAS). The antibacterial activity of the nanomaterial against Escherichia coli (ATCC 22652), Enterococcus faecalis (ATCC 29282), Pseudomonas aeruginosa (ATCC 27853) and Staphylococcus aureus (ATCC 25923) was carried out using 500 mg of silver nanocomposite. Pseudomonas aeruginosa and Acinetobacter baumannii multidrug-resistant strains, isolated from hospitalized patients were also included in the study. The biosynthesized silver nanocomposite showed spherical nanoparticles with sizes smaller than 10 nm; 1 g of nanocomposite contained 49.24 µg of silver. Multidrug-resistant strains of Pseudomonas aeruginosa and Acinetobacter baumannii, and the other Gram-positive and Gram-negative bacteria tested, were sensitive to the silver nanocomposite (10-12.9 mm of inhibition zone). The biosynthesized silver nanocomposite seems to be a promising antibacterial agent for different applications, namely biomedical devices or topical wound coatings.

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Section: Bacterial Strain Zone Of Inhibition (Mm) Xg 500 Mg/mlsupporting

confidence: 87%

Silver Nanocomposite Biosynthesis: Antibacterial Activity against Multidrug-Resistant Strains of Pseudomonas aeruginosa and Acinetobacter baumannii

et al. 2016

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“…Deviations from observed MIC between studies results from difference in particle size as well as experimental methods [7]. Studies also show the importance of particulate metal oxides and metal salts as antimicrobial agents towards eukaryotic as well as prokaryotic microorganisms [8,9]. The efficacy of this class of antimicrobial agents as well as the range of applications highlight the importance of understanding and developing technologies to control microbial populations.…”

Section: Discussionmentioning

confidence: 99%

Traditional Biocidal Replacement Viability of Microcrystalline Silver Chloride

Hemminger¹,

Walsh²,

Curtis³

et al. 2017

J Nanomed Nanotechnol

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“…This strain selective mycobactericidal activity showed no DNA damage, cytotoxic or toxic effect to macrophages upto treatment with 5 ppm of silver nanoparticles making silver nanoparticles a suitable therapeutic option for mycobacterial infections. Study of Singh et al (2015) further backed anti-mycobacterial efficiency of silver nanoparticles. This study revealed that the silver nanoparticles were specific towards mycobacteria strains when in comparison to other Gram positive and Gram negative bacteria.…”

Section: Antimicrobial Options For Map With Special Reference To Nanomentioning

confidence: 99%

Nanotechnology Based Therapeutics, Drug Delivery Mechanisms and Vaccination approaches for Countering Mycobacterium avium subspecies paratuberculosis (MAP) Associated Diseases

Stephen¹,

Jain²,

Dhama³

et al. 2015

Asian J. of Animal and Veterinary Advances

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Johne's Disease (JD) is a contagious fatal granulomatous enteritis, known to affect ruminants and is caused by the acid-fast Mycobacterium avium subspecies paratuberculosis (MAP). The bacterium has also been linked to Crohn's Disease (CD) in humans. Treatment options are scarce with culling practiced in the case of Johne's Disease (JD) and administration of anti-inflammatory drugs for pain and inflammation in case of CD. In both cases antimicrobial therapy against MAP does not have the ultimate potential. The very promising, yet untapped potential of nanotechnology offers a suitable platform for developing new therapeutic strategies for diseases caused by the bacteria. Uniformity, specificity and reproducibility are some of the characteristics of nanotechnology that can be exploited for the treatment of infectious diseases. Factors like cost, efficacy, safety and bioavailability of drugs can be greatly improved when the drugs are delivered with precision and at a controlled delivery rate to the target location. Nanotechnology can help in achieving these targets. This review discusses the current scenario of available therapeutic approaches and proposes drugs targeting strategies and vaccine development methods for the treatment and prevention of MAP related diseases.

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Chemical and biological metal nanoparticles as antimycobacterial agents: A comparative study

Cited by 95 publications

References 25 publications

Silver Nanocomposite Biosynthesis: Antibacterial Activity against Multidrug-Resistant Strains of Pseudomonas aeruginosa and Acinetobacter baumannii

Silver Nanocomposite Biosynthesis: Antibacterial Activity against Multidrug-Resistant Strains of Pseudomonas aeruginosa and Acinetobacter baumannii

Traditional Biocidal Replacement Viability of Microcrystalline Silver Chloride

Nanotechnology Based Therapeutics, Drug Delivery Mechanisms and Vaccination approaches for Countering Mycobacterium avium subspecies paratuberculosis (MAP) Associated Diseases

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