Chemical and biological characterization of sulfated chitosan oligomer as heparin mimics

Kocabay, Samet; Bahar, Mehmet Refik; Tekin, Suat; Akkaya, Recep; Akkaya, Birnur

doi:10.1177/09673911211035068

Cited by 4 publications

(3 citation statements)

References 58 publications

(64 reference statements)

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“…Chitosan oligomers have two reflections at 2θ = 14°, 2θ = 24°. The reflection at 2 = 14° was associated with crystal form I (Kocabay et al, 2021). The XRD pattern of chitosan stearic acid shows two sharp diffraction peaks at 21.3 ° and 23.6 ° (Hamza et al, 2021).…”

Section: Resultsmentioning

confidence: 99%

Magnetic chitosan oligomer‐sulfonate‐stearic acid triple combination as cisplatin carrier for site‐specific targeted on MCF‐7 cancer cells: Preparation, characterization and in vitro experiments

Akkaya,

Nazlim

2023

Chem Biol Drug Des

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In this study, a new amphiphilic target‐specific adsorbent, chitosan oligomer‐sulfonate‐stearic acid triple combination (S‐Cho‐SA), and magnetic chitosan oligomer‐sulfonate‐stearic acid triple combination (M‐S‐Cho‐SA) by oleic acid (OA)‐modified Fe3O4 via hydrophobic interaction are fabricated. By modifying the nanoparticle surfaces and having the ability to magnetically allow the target region, these particles attract attention as important particles used in targeting mechanisms in cancer therapy. With magnetic nanoparticles and an external magnetic field, it is possible to transport therapeutic agents to the target site and keep them in the desired effect zone for a longer period of time. These new adsorbents are characterized by scanning electron microscopy (SEM), attenuated total reflection Fourier transform infrared (ATR FT‐IR) spectroscopy, nuclear magnetic resonance (NMR), X‐ray diffraction (XRD), vibrating sample magnetometer (VSM), and thermogravimetric analysis (TG/DTA). After chemical characterization, it is complexed with cisplatin (CDDP). The magnetic adsorbents were loaded with high efficiency (>50%), and the release experiments exhibited that cisplatin is released more at pH 4.5 compared with pH 7.4 at 37°C. It showed better drug release results under a magnetic field for magnetic adsorbents (36% for pH 4.5 and 3.6% for pH 7.4). The biocompatibility of the prepared adsorbents was demonstrated via the XTT assay in MCF‐7 cell lines. The results also exhibited that S‐Cho‐SA and M‐S‐Cho‐SA were biocompatible, and free cisplatin and cisplatin‐complexed adsorbents showed an antiproliferative effect. The results showed that these new cisplatin‐loaded (M‐S‐Cho‐SA) nanoparticles are good candidates for thermotherapy in cancer treatment in the future, as they can provide selectivity by site‐specific targeting and hold onto an alternative magnetic field due to the magnetic nature of the nanoparticles.

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Section: Resultsmentioning

confidence: 99%

Magnetic chitosan oligomer‐sulfonate‐stearic acid triple combination as cisplatin carrier for site‐specific targeted on MCF‐7 cancer cells: Preparation, characterization and in vitro experiments

Akkaya,

Nazlim

2023

Chem Biol Drug Des

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“…In a study conducted by Samet et al (85), it was found that sulfated chitosan oligomer (ShCsO) is a heparin mimetic. The researchers modified chitosan oligomers into ShCsO and studied its chemical composition and biological properties.…”

Section: Chitosan 6-o Sulfatementioning

confidence: 99%

Chitosan, Its Derivatives, Sources, Preparation Methods, and Applications: A Review

HEMMAMI,

BEN AMOR,

BEN AMOR

et al. 2024

Journal of the Turkish Chemical Society Section A: Chemistry

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Chitosan is a type of biopolymer that can be derived from various natural sources, including animals and marine organisms. When determining its quality, molecular weight, crystallinity, and degree of deacetylation of chitosan are considered. Biocompatibility, bioadhesive, solubility, and polycationic character are all based on these traits. Chitosan’s characteristics make it a good and appealing material for a variety of physical and chemical alterations. This review talks about the structure of chitosan and its properties. It also covers how chitosan is extracted from different sources. Special emphasis is placed on its utilization in the formation of metallic nanoparticles, drug delivery, and wastewater treatment.

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“…Recently, researchers have greatly focused on the bioactivities of polysaccharides and their derivatives, especially sulfated polysaccharides (SPS) . SPS are anionic polymers consisting of several functional groups and possess a wide range of biological properties, such as antioxidant, anticoagulant, and antithrombic activities .…”

Section: Introductionmentioning

confidence: 99%

Antiblood Cell Adhesion of Mussel-Inspired Chondroitin Sulfate- and Caffeic Acid-Modified Polycarbonate Membranes

et al. 2022

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We fabricated a mussel-inspired hemocompatible polycarbonate membrane (PC) modified by the cross-linking of chondroitin sulfate and caffeic acid polymer using CA-CS via a Schiff base and Michael addition reaction and named it CA-CS-PC. The as-fabricated CA-CS-PC membrane shows excellent hydrophilicity with a water contact angle of 0° and a negative surface charge with a zeta potential of −32 mV. The antiadhesion property of the CA-CS-modified PC membrane was investigated by enzyme-linked immunosorbent assay (ELISA), using human plasma protein fibrinogen adsorption studies, and proved to have excellent antiadhesion properties, because of the lower fibrinogen adsorption. In addition, the CA-CS-PC membrane also shows enhanced hemocompatibility. Finally, blood cell attachment tests of the CA-CS-PC membrane were observed by CLSM and SEM, and the obtained results proved that CA-CS-PC effectively resisted cell adhesion, such as platelets and leucocytes. Therefore, this work disclosed a new way to design a simple and versatile modification of the membrane surface by caffeic acid and chondroitin sulfate and apply it for cell adhesion.

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Chemical and biological characterization of sulfated chitosan oligomer as heparin mimics

Cited by 4 publications

References 58 publications

Magnetic chitosan oligomer‐sulfonate‐stearic acid triple combination as cisplatin carrier for site‐specific targeted on MCF‐7 cancer cells: Preparation, characterization and in vitro experiments

Magnetic chitosan oligomer‐sulfonate‐stearic acid triple combination as cisplatin carrier for site‐specific targeted on MCF‐7 cancer cells: Preparation, characterization and in vitro experiments

Chitosan, Its Derivatives, Sources, Preparation Methods, and Applications: A Review

Antiblood Cell Adhesion of Mussel-Inspired Chondroitin Sulfate- and Caffeic Acid-Modified Polycarbonate Membranes

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