Chemical analysis of the Chinese herbal medicine licorice (Gan-Cao): An update review

Shang, Zhanpeng; Liu, Chenrui; Qiao, Xue; Ye, Min

doi:10.1016/j.jep.2022.115686

Cited by 31 publications

(19 citation statements)

References 118 publications

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“…Some scholars have proposed the idea of “quality evaluation by morphological identification” ( Xie, 1994 ). The current quality evaluation methods of Chinese herbs rely more on chromatographic pharmacodynamics ( Ma et al, 2022 ; Yan and Zou, 2022 ), serum pharmacochemistry ( Wu et al, 2019 ; Tang et al, 2022 ), pharmacokinetics ( Ouyang et al, 2022 ; Shang et al, 2022 ), metabonomics ( Ning et al, 2013 ; Feng et al, 2020 ), quality markers ( Zhang et al, 2018a ; Ren et al, 2020 ), biological effect detection ( Wang et al, 2013 ; Zhang et al, 2022 ), and other modern scientific techniques, while the most common method relies on the fingerprinting techniques to determine the content of active ingredients to evaluate and control the quality of Chinese herbs ( Zhang and Jiang, 2021 ). A holistic view and evidence-based treatment are the significant features of the theoretical system of Chinese herbs, and the quality of Chinese herbs is the result of the overall performance of its multi-components and multi-effects ( Liu et al, 2019 ).…”

Section: Introductionmentioning

confidence: 99%

A biophoton method for identifying the quality states of fresh Chinese herbs

et al. 2023

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Introduction: The quality of Chinese herbs is the basis for ensuring their safety and efficacy. However, the quality evaluation system is imperfect. In particular, there is a lack of quality evaluation methods for fresh Chinese herbs during growth. The biophoton is a common phenomenon and provides complete information about the interior of the living system, which is consistent with the holistic concept of traditional Chinese medicine. Therefore, we aim to correlate the biophoton characteristics with the quality states to find the biophoton parameters that can characterize the quality states of fresh Chinese herbs.Methods: The biophoton characteristics of motherwort and safflower were measured and characterized by the counts per second (CPS) in the steady state and the initial intensity (I0) and coherent time (T) of delayed luminescence. The active ingredient content was measured by ultra-high-performance liquid chromatography (UPLC). The pigment content of motherwort leaves was measured by UV spectrophotometry. The t-test and correlation analysis were performed on the experimental results.Results: The CPS and I0 of motherwort and I0 of safflower showed a significant downward trend during the growth process, and their active ingredient content showed a trend that increased and then decreased. The CPS, I0, and the content of active ingredients and pigments in a healthy state were significantly higher than those in a poor state, while T showed the opposite results. The CPS and I0 were all significantly and positively correlated with the content of active ingredients and pigments, while the T of motherwort showed the opposite results.Conclusion: It is feasible to identify the quality states of fresh Chinese herbs by using their biophoton characteristics. Both CPS and I0 have better correlations with the quality states and can be considered characteristic parameters of the quality of fresh Chinese herbs.

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Section: Introductionmentioning

confidence: 99%

A biophoton method for identifying the quality states of fresh Chinese herbs

et al. 2023

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“…Characterization of triterpenoids Triterpenoids, which naturally occur as O ‐glycosides (saponins), are another class of bioactive ingredients in the JFH formula, mainly from AR [17] and GRR [22]. The triterpenoids arising from GRR generally exhibited oleanane‐type skeletons.…”

Section: Resultsmentioning

confidence: 99%

An efficient approach addressing the chemical complexity of Jiawei Fangji Huangqi decoction by integrating ultra‐high‐performance liquid chromatography/ion mobility‐quadrupole time‐of‐flight mass spectrometry and intelligent data processing workflows

Jiang

Zhao

Zou

et al. 2023

J of Separation Science

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A challenge in the quality control of traditional Chinese medicine is the systematic multicomponent characterization of the compound formulae. Jiawei Fangji Huangqi, a modified form of Fangji Huangqi, is a prescription comprising seven herbal medicines. To address the chemical complexity of the Jiawei Fangji Huangqi decoction, we integrated ion mobility‐quadrupole time‐of‐flight high‐definition MSE coupled to ultra‐high‐performance liquid chromatography and intelligent data processing workflows available in the UNIFI software package. Good chromatographic separation was achieved on CORTECS UPLC T3 column within 52 min, and high‐accuracy MS2 data were acquired using high‐definition MSE in the negative and positive modes. A chemical library of 1250 compounds was created and incorporated into the UNIFI software to enable automatic peak annotation of the high‐definition MSE data. We identified or tentatively characterize 430 compounds in the Jiawei Fangji Huangqi decoction. The potential superiority of high‐definition MSE over conventional MS data acquisition approaches was revealed in its spectral quality (MS2), differentiation of isomers, separation of coeluting compounds, and target mass coverage. The multiple components of the Jiawei Fangji Huangqi decoction were elucidated, offering insight into its improved pharmacological action compared with that of the Fangji Huangqi formula.

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“…More than 30 species of GRER are found worldwide, of which three are identified by the Chinese Pharmacopoeia (2020) as GRER (Commission, 2020; Duan et al, 2020; Rizzato et al, 2017). In China, most GRER grows in the Inner Mongolia, Xinjiang Uygur, and Ningxia Hui autonomous regions, as well as Gansu, Shaanxi, and Shanxi provinces (Ding et al, 2022; Shang et al, 2022). The global geographical distribution of the three GRER species, according to the Global Biodiversity Information Facility (GBIF) website, is shown in Figure 2.…”

Section: Introductionmentioning

confidence: 99%

Glycyrrhizae Radix et Rhizoma: The popular occurrence of herbal medicine applied in classical prescriptions

Kang

Zhang

et al. 2023

Phytotherapy Research

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Glycyrrhizae Radix et Rhizoma is a well-known herbal medicine with a wide range of pharmacological functions that has been used throughout Chinese history. This review presents a comprehensive introduction to this herb and its classical prescriptions. The article discusses the resources and distribution of species, methods of authentication and determination chemical composition, quality control of the original plants and herbal medicines, dosages use, common classical prescriptions, indications, and relevant mechanisms of the active content. Pharmacokinetic parameters, toxicity tests, clinical trials, and patent applications are discussed. The review will provide a good starting point for the research and development of classical prescriptions to develop herbal medicines for clinical use.

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Chemical analysis of the Chinese herbal medicine licorice (Gan-Cao): An update review

Cited by 31 publications

References 118 publications

A biophoton method for identifying the quality states of fresh Chinese herbs

A biophoton method for identifying the quality states of fresh Chinese herbs

An efficient approach addressing the chemical complexity of Jiawei Fangji Huangqi decoction by integrating ultra‐high‐performance liquid chromatography/ion mobility‐quadrupole time‐of‐flight mass spectrometry and intelligent data processing workflows

Glycyrrhizae Radix et Rhizoma: The popular occurrence of herbal medicine applied in classical prescriptions

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