Glycyrrhizae Radix et Rhizoma: The popular occurrence of herbal medicine applied in classical prescriptions

Abstract

Glycyrrhizae Radix et Rhizoma is a well-known herbal medicine with a wide range of pharmacological functions that has been used throughout Chinese history. This review presents a comprehensive introduction to this herb and its classical prescriptions. The article discusses the resources and distribution of species, methods of authentication and determination chemical composition, quality control of the original plants and herbal medicines, dosages use, common classical prescriptions, indications, and relevant mechanisms of the active content. Pharmacokinetic parameters, toxicity tests, clinical trials, and patent applications are discussed. The review will provide a good starting point for the research and development of classical prescriptions to develop herbal medicines for clinical use.

Antitumor immunostimulatory activity of the traditional Chinese medicine polysaccharide on hepatocellular carcinoma

“…Therefore, interventions targeting Treg cells have become the new strategy of many therapies for malignant tumors ( 106 , 107 ). Radix Glycyrrhizae is a commonly used traditional Chinese herbal medicine with a wide range of pharmacological functions throughout Chinese history, and the polysaccharide is a major active compound extracted from it, which is cytotoxic to cancer cells ( 108 , 109 ). An in vivo experimental study with H22 hepatocarcinoma-bearing BALB/c mice has shown that Radix Glycyrrhizae Polysaccharide could down-regulate the population of Treg cells and decrease the expression of Foxp3 mRNA and IL-10 mRNA in the lymph node.…”

Metabolite Profiling Analysis of the Tongmai Sini Decoction in Rats after Oral Administration through UHPLC-Q-Exactive-MS/MS

“…The classical prescriptions of traditional Chinese medicine (TCM) have originated from the fixed combination of certain kinds of herbal medicines recorded in the ancient classics, which have been still widely used in East Asia and exhibited precise clinical efficacy, with obvious characteristics and advantages [ 1 ]. For a long time, some classic prescriptions have been developed into modern Chinese medicinal preparations through the optimization of preparation technology and drug development research [ 2 , 3 ].…”