Chemical allergens stimulate human epidermal keratinocytes to produce lymphangiogenic vascular endothelial growth factor

Bae, Ok‐Nam; Ahn, Se-Yeon; Sun, Jing; Hong, Soo Hyun; Lee, Jin Young; Kim, Eun Sun; Jeong, Tae Cheon; Chun, Young‐Jin; Lee, Ai-Young; Noh, Minsoo

doi:10.1016/j.taap.2015.01.008

Cited by 16 publications

(8 citation statements)

References 48 publications

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“…Furthermore, it plays crucial roles in the pathogenesis of certain autoimmune diseases such as psoriasis, inflammatory bowel disease, and systemic lupus erythematosus [ 5 – 7 ]. Up to now, rare studies have been focused on the roles of IL-22 in the pathogenesis of cardiovascular disease, particularly the vascular endothelial cells [ 8 ]. In this study, we aim to investigate the roles of IL-22 in the onset of ALI in mice and the cultivated PMVECs treated by AngII.…”

Section: Introductionmentioning

confidence: 99%

JAK2/STAT3 Pathway Was Associated with the Protective Effects of IL-22 On Aortic Dissection with Acute Lung Injury

Ren

Wang

et al. 2017

Disease Markers

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Patients with aortic dissection (AD) may present acute lung injury (ALI) that may affect the prognosis. In this study, we aim to investigate the roles and mechanism of IL-22 in the pathogenesis of AD complicated with ALI. Six hundred and twenty-one AD patients were included, and the incidence of ALI and pulmonary CT findings were analyzed. Mouse ALI model was established through AngII, and then IL-22 injection and AG490 were given. The pathological changes, infiltration of inflammatory cells, and expression of STAT3 were determined. For the in vitro experiment, cultivated pulmonary microvascular endothelial cells (PMVECs) were treated by angiotensin II (AngII), followed by treating with IL-22 and/or AG490. The expression and migration of STAT3 was determined. Flow cytometry was carried out to evaluate the apoptosis. IL-22 contributed to the expression of STAT3 in lung tissues and attenuation of ALI. IL-22 obviously inhibited the apoptosis of PMVECs mediated by AngII and downregulated the expression and intranuclear transmission of STAT3. Such phenomenon was completely inhibited upon administration of AG490, an inhibitor of JAK2. Our data showed IL-22 contributed to the inhibition of PMVEC apoptosis mediated by AngII through activating the JAK2/STAT3 signaling pathway, which may attenuate the ALI induced by AngII.

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Section: Introductionmentioning

confidence: 99%

JAK2/STAT3 Pathway Was Associated with the Protective Effects of IL-22 On Aortic Dissection with Acute Lung Injury

Ren

Wang

et al. 2017

Disease Markers

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“…These cytokines play crucial roles in various inflammatory skin diseases such as psoriasis and atopic dermatitis [13][14][15]. Moreover, IL-1, IL-6, IL-8, TNF-a, and MCP-1 are closely related to the wound healing process and are used for wound age determination [16,17]. Nuclear factor kappa B (NF-kB) is a major factor mediating UVB-induced inflammatory responses through the expression of various proinflammatory proteins such as inducible nitric oxide synthase, TNF-a, and IL-6 [18][19][20].…”

Section: Introductionmentioning

confidence: 99%

Topical application of glycolic acid suppresses the UVB induced IL-6, IL-8, MCP-1 and COX-2 inflammation by modulating NF-κB signaling pathway in keratinocytes and mice skin

Tang

Liao

Hung

et al. 2017

Journal of Dermatological Science

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“…The VEGFC protein functions mainly in the process of lymphangiogenesis but has also been implicated in the promotion of tumor metastasis and growth [37]. VEGFC gene transcription was significantly increased in allergen-stimulated keratinocytes, but the VEGFC protein itself was not reported to directly affect the in vitro proliferation of epidermal keratinocytes [38,39]. In the context of high-risk HPV infection, VEGFC expression was stimulated by cigarette smoke and associated with the grade of cervical intraepithelial neoplasia [40,41].…”

Section: Discussionmentioning

confidence: 99%

Gene Expression Profiling of MicroRNAs in HPV-Induced Warts and Normal Skin

et al. 2019

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Infection with the human papillomavirus (HPV) is a common occurrence among the global population, with millions of new cases emerging on an annual basis. Dysregulated microRNA (miRNA) expression is increasingly being identified to play a role in a number of different diseases, especially in the context of high-risk HPV infection. The present study investigated the miRNA expression profiles of warts induced by low-risk HPV. In warts, miR-27b, miR-24-1, miR-3654, miR-647, and miR-1914 were downregulated while miR-612 was upregulated compared to normal skin. Using miRTargetLink Human, experimentally supported evidence was obtained showing that miR-27b targeted the vascular endothelial growth factor C (VEGFC) and CAMP-responsive element binding protein 1 (CREB1) genes. The VEGFC and CREB1 genes have been reported to be involved in tumorigenesis and wart formation, respectively. Similarly, the oxidized low-density lipoprotein receptor 1 (OLR1) gene, which plays an important role in the humoral immunity of the skin, and the plexin D1 (PLXND1) gene, which is highly expressed in tumor vasculature, were both found to be common targets of miR-27b, miR-1914, and miR-612.

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Chemical allergens stimulate human epidermal keratinocytes to produce lymphangiogenic vascular endothelial growth factor

Cited by 16 publications

References 48 publications

JAK2/STAT3 Pathway Was Associated with the Protective Effects of IL-22 On Aortic Dissection with Acute Lung Injury

JAK2/STAT3 Pathway Was Associated with the Protective Effects of IL-22 On Aortic Dissection with Acute Lung Injury

Topical application of glycolic acid suppresses the UVB induced IL-6, IL-8, MCP-1 and COX-2 inflammation by modulating NF-κB signaling pathway in keratinocytes and mice skin

Gene Expression Profiling of MicroRNAs in HPV-Induced Warts and Normal Skin

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