Chemerin, Resistin, and Adiponectin in Patients with Connective Tissue Diseases

Abstract

SummaryBackgroundThe exact role of cytokines in inflammation and metabolic disorders in case of connective tissue diseases (CTDs) is under discussion.MethodsIn this study, we intended to find the relationship between the selected cytokines in inflammatory and metabolic disorders in patients with CTDs (n=55) and compared the results with those of control group subjects (n=25) matched by age and body mass. We estimated their nutritional status by the bioimpedance method. The levels of basic biochemical parameters and the levels of adiponectin, resistin, and chemerin were also estimated. Multiple regressions and area under the curve in receiver operating characteristic (AUC–ROC) curve were used to find the associations of aforementioned parameters.ResultsPatients with CTDs exhibited higher levels of chemerin than that of control group subjects. We found an inverse relationship between chemerin, RBC count, and hemoglobin levels. The concentration of adiponectin inversely correlated with the levels of platelets and concentrations of glucose and triglycerides as well as the erythrocyte sedimentation rate, whereas the concentration of resistin was positively correlated with WBC count, C-reactive protein (CRP), and the amount of used oral glucocorticosteroids. The mean ± standard deviation for the AUC–ROC curve in case of chemerin was the highest (AUC–ROC=0.714, p=0.0005) than that of both resistin and adiponectin.ConclusionsChemerin and resistin levels are related to the inflammatory state in patients with CTDs, whereas adiponectin levels seem to be correlated with a protective effect. Chemerin can be considered as a marker differentiating a proinflammatory state present in CTDs.

Altered serum level of metabolic and endothelial factors in patients with systemic sclerosis

“…In this study, a statistically significant increased concentration of resistin was found in patients with SSc. It complies with the elevated serum resistin level in other chronic systemic inflammatory diseases, including rheumatoid arthritis and systemic lupus erythematosus [19,20]. Taking into consideration biological profile of action, this observation suggests that increased level of resistin results in severe inflammation which seems to play one of the major roles in the pathogenesis of SSc.…”

Are Vaspin and Omentin-1 Related to Insulin Resistance, Blood Pressure and Inflammation in NAFLD Patients?

“…These controversies in reported results may in part be due to the different influences of various chronic inflammatory diseases on vaspin concentrations. Thus, further studies with larger participants are needed to investigated vaspin and inflammatory cytokines associations (34, 35).…”

“…Clinical studies demonstrated the close relationship between plasma vaspin levels and atherosclerosis, so, vaspin might be involved in the coronary artery disease (CAD) process (35, 36, 37). Experiments also indicated that vaspin could inhibit the release of key inflammatory markers in vascular smooth muscle cells and prevent FFA-induced apoptosis in endothelial cells, also vaspin could inhibit proliferation of vascular smooth muscle cells which induced by chemokinesis inactivation of ROS and MAPK, PI3K/Akt, and NF-kB signaling (12, 36).…”

Are Vaspin and Omentin-1 Related to Insulin Resistance, Blood Pressure and Inflammation in NAFLD Patients?

“…Previous animal studies indicated that omentin improves endothelial functions and prevented blood pressure elevation in rats through endothelium-dependent relaxation. It has been determined that omentin increases the phosphorylation of eNOS and consequently induced relaxation in endothelium (35,39). As mentioned, obese subjects have significantly reduced omentin levels, so omentin low level may play at least in part a key role in accompanied hyper-tension in obese patients (40).…”

“…Clinical studies demonstrated the close relationship between plasma vaspin levels and atherosclerosis, so, vaspin might be involved in the coronary artery disease (CAD) process (35)(36)(37). Experiments also indicated that vaspin could inhibit the release of key inflammatory markers in vascular smooth muscle cells and prevent FFA-induced apoptosis in endothelial cells, also vaspin could inhibit proliferation of vascular smooth muscle cells which induced by chemo kinesis inactivation of ROS and MAPK, PI3K/Akt, and NF-kB signaling (12,36).…”