Chemerin in Non-Alcoholic Fatty Liver Disease ? Up or Down?

Buechler, Christa

doi:10.4172/2161-1017.1000e117

Cited by 2 publications

(1 citation statement)

References 34 publications

(64 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This excessive storage of fat in the liver makes the organ susceptible to inflammation and fibrosis. NAFLD is strongly associated with obesity, type 2 diabetes mellitus (T2DM), and cardiovascular disease [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Serum Omentin-1, Vaspin, Leptin, Adiponectin Levels in Obese/Overweight Children and Their Relationship With Non-Alcoholic Fatty Liver Disease

2022

View full text Add to dashboard Cite

To investigate adipokines (vaspin, omentin-1, adiponectin and leptin) and their correlation with hepatosteatosis degree in obese/overweight (O/O) children. We analyzed adipokine levels of 81 children (49 O/O, [body mass index (BMI) > 95 th ] and 32 non-obese (BMI = 5-85 th ) admitted to the pediatric outpatient clinic. Serum triglyceride, glucose, low density lipoprotein-cholesterol, total cholesterol, high density lipoprotein-cholesterol, alanine aminotransferase, aspartate aminotransferase (AST), insulin, HbA1c levels and leptin, omentin-1, vaspin, adiponectin levels were studied. O/O children with hepatosteatosis were divided into grades 1, 2 and 3 according to the degree of hepatosteatosis determined by ultrasonography. While AST (p = 0.001), triglyceride (p = 0.006), BMI percentile (p = 0.000), HOMA index (p = 0.002), systolic blood pressure (p = 0.02), leptin (p = 0.001), omentin-1 (p = 0.001), adiponectin (p = 0.001) levels were higher, vaspin level was lower (p = 0.008) in the (O/O) group compared to the controls. There was a positive correlation between HDL and vaspin, and a negative correlation between HDL and omentin-1 in the O/O group. Also it was observed that as the degree of hepatosteotosis increased, leptin (p = 0.004), omentin-1 (p = 0.001) levels were increased. There was no significant change in vaspin level (p = 0.128). The high levels of omentin-1, leptin and adiponectin have an association with the development of hepatosteatosis in O/O children.

show abstract

Section: Introductionmentioning

confidence: 99%