Chemerin, IL-18 and IL-1 Beta as Biomarkers of Metabolic Syndrome in Egyptian Obese Children

Gad, Suzan; Shora, Hassan A; Abdelwahab, Amina; Abdou, Rania M.; Raouf, Batoul M. Abdel; Elmikaty, Hani A; Nassar, Sanaa; Ali, Ahmed; Ismail, Hussein; Dahshan, Ismail

doi:10.31080/asms.2022.06.1310

Cited by 3 publications

(4 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Gad et al. ( 78 ) revealed higher chemerin serum levels in obese children with metabolic syndrome. In his study chemerin positively correlated with fasting blood glucose and negatively with HDL-C. Other studies confirmed positive relationship between chemerin and insulin and HOMA-IR ( 25 – 27 ).…”

Section: Discussionmentioning

confidence: 99%

The link between vitamin D, chemerin and metabolic profile in overweight and obese children - preliminary results

et al. 2023

View full text Add to dashboard Cite

BackgroundVitamin D affects adipogenesis, oxidative stress, inflammation, secretion of adipocytokines, lipid metabolism and thermogenesis. Some researchers postulate that those effects could be exerted by the influence of vitamin D on chemerin levels.Aim of the studyWe aimed to investigate if there is a link between serum 25-hydroksyvitamin D [25(OH)D], chemerin and metabolic profile in overweight and obese children before and after vitamin D supplementation.Material and methodsThe prospective study included 65 overweight and obese children aged 9.08-17.5 years and 26 peers as a control. None of the patients in the study group had received vitamin D within the last twelve months before the study.ResultsThe study group had lower baseline 25(OH)D (p<0.001) and higher chemerin (p<0.001), triglycerides (TG, p<0.001), triglycerides/high density lipoprotein cholesterol (TG/HDL-C, p<0.001), C-reactive protein (CRP, p<0.05), fasting insulin (p<0.001), Homeostasis Model Assessment - Insulin Resistance (HOMA-IR, p<0.001), alanine aminotransferase (ALT, p<0.001) and uric acid (p<0.001) compared to the control group. Baseline vitamin D was related to fasting insulin (R=-0.29, p=0.021), HOMA-IR (R=-0.30, p=0.016), HDL-C (R=0.29, p=0.020) and uric acid (R=-0.28, p=0.037) in the study group. Baseline chemerin was related to insulin at 30’ (R=0.27, p=0.030), 60’ (R=0.27, p=0.033), 90’ (R=0.26, p=0.037) and 120’ (R=0.26, p=0.040) during the oral glucose tolerance test (OGTT) and ALT (R=0.25, p=0.041) in the study group. Correlation between vitamin D and chemerin (R=-0.39, p=0.046) was found only in the control group. After six months of vitamin D supplementation a decrease in CRP (p<0.01), total cholesterol (p<0.05), ALT (p<0.01), glucose at 150’ OGTT (p<0.05) was observed. Moreover, we noticed a tendency for negative association between 25(OH)D and chemerin levels (p=0.085). Multivariable backward linear regression models were build using baseline vitamin D, baseline chemerin and six months chemerin as the dependent variables.ConclusionsOur study confirmed that vitamin D has positive effect on metabolic profile in overweight and obese children. The relationship between vitamin D and chemerin is not clear, nevertheless we have observed a tendency to decrease chemerin concentrations after improving vitamin D status, even without a significant reduction in body fat mass.

show abstract

Section: Discussionmentioning

confidence: 99%

The link between vitamin D, chemerin and metabolic profile in overweight and obese children - preliminary results

et al. 2023

View full text Add to dashboard Cite

show abstract

“…It's a long-term inflammatory disease. It has been found that the adipocytokines chemerin, IL-8, and IL-1 beta play a crucial role in the link between Met S and inflammation and could serve as useful diagnostic and monitoring markers for the condition (21) .…”

Section: Figure (2)mentioning

confidence: 99%

“…Type II diabetes mellitus is a metabolic disorder characterised by decreased insulin production and elevated blood glucose levels (hyperglycemia). The development of type 2 diabetes mellitus is strongly associated with serum chemerin increases, which are correlated with obesity (21) .…”

Section: Chemerin and Glucose Homeos Tasismentioning

confidence: 99%

See 1 more Smart Citation

Biological Role of Chemerin in Inflammatory Skin Disease: Review Article

Ghonemy¹,

Elsaid²,

Ibrahim³

et al. 2023

The Egyptian Journal of Hospital Medicine

View full text Add to dashboard Cite

Background: Chemerin is a novel adipokine that has been found to function in both autocrine and paracrine pathways. It draws in both innate and adaptive immune cells as a chemoattractant. There are several roles for this pro-inflammatory chemokine. Also called retinoic acid receptor responder 2 (RAR2) and tazarotene-induced gene 2 (TIG2). The protein chemerin is involved in a variety of processes, including metabolism, inflammation, and adipogenesis, as well as vascular dysregulation. Chemerin was evaluated among different inflammatory skin diseases and showed significant correlations. Objective: Review of the biological role of chemerin in inflammatory skin disease. Methods: We looked for data on Chemerin, Biological role and Inflammatory skin disease in medical journals and databases like PubMed, Google Scholar, and Science Direct. However, only the most recent or extensive study was taken into account between February 2015 and January 2023. References from related works were also evaluated by the authors. There are not enough resources to translate documents into languages other than English, hence those documents have been ignored. It was generally agreed that documents such as unpublished manuscripts, oral presentations, conference abstracts, and dissertations did not qualify as legitimate scientific study. Conclusion: Psoriatic individuals had increased chemerin levels in their skin biopsies. Also serum chemerin levels were found to increase with acne vulgaris disease severity. Recent research has found a correlation between obesity and atopic dermatitis, an inflammatory skin condition. Adipokines can be used as a marker for the degree to which eczema is present.

show abstract

Association of RARRES2 rs17173608 gene polymorphism and serum Chemerin with acute myocardial infarction and its risk factors: A case-control study in an Iranian population

Pirsaraei,

Khodabandehloo,

Mousavi

et al. 2024

Gene

View full text Add to dashboard Cite

Chemerin, IL-18 and IL-1 Beta as Biomarkers of Metabolic Syndrome in Egyptian Obese Children

Cited by 3 publications

References 18 publications

The link between vitamin D, chemerin and metabolic profile in overweight and obese children - preliminary results

The link between vitamin D, chemerin and metabolic profile in overweight and obese children - preliminary results

Biological Role of Chemerin in Inflammatory Skin Disease: Review Article

Association of RARRES2 rs17173608 gene polymorphism and serum Chemerin with acute myocardial infarction and its risk factors: A case-control study in an Iranian population

Contact Info

Product

Resources

About