Chemerin expression in Chinese pregnant women with and without gestational diabetes mellitus

Li, Xuemei; Ji, Hui; Li, Chunjun; Wang, Penghua; Yu, Pei; Yu, Di

doi:10.1016/j.ando.2014.10.001

Cited by 33 publications

(32 citation statements)

References 35 publications

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“…Garces et al (23) found no significant association of insulin and HOMA levels with chemerin, as did other independent studies (11,24,25). We found similar results for chemerin in pregnant women with GDM; however, other studies presented an association of chemerin with insulin resistance in pregnancy (26,27). Overall, it appears that chemerin may not be useful in predicting GDM.…”

Section: Discussionsupporting

confidence: 44%

Are adipokines associated with gestational diabetes mellitus?

Görkem¹,

Küçükler²,

Toğrul³

et al. 2016

J Turkish German Gynecol Assoc

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Conclusion:No differences were found in serum chemerin, RBP-4, and visfatin between pregnant women with GDM and healthy pregnant women. Further prospective studies will be essential to elucidate the contribution of adipokines to GDM and the positive correlation between maternal RBP-4 and chemerin. (J Turk Ger Gynecol Assoc 2016; 17: 186-90) Keywords: Chemerin, retinol binding protein-4, visfatin, gestational diabetes Received: 13 July, 2016 Accepted: 15 October, 2016 Are adipokines associated with gestational diabetes mellitus? Abstract levels of chemerin are detected in obesity and are associated with multiple components of metabolic syndromes, including body mass index (BMI), triglycerides, high density cholesterol, hypertension, inflammation, and markers of liver pathology (10). Chemerin is also expressed in human placenta (11). Serum levels of chemerin correlate significantly with systemic markers of inflammation, such as TNF-alpha, interleukin 6, and C-reactive protein (12). Overall, these findings suggest that chemerin levels are related to adiposity and glucose metabolism. They also represent a possible link between obesity and the development of GDM. Retinol binding protein-4 is a blood carrier protein for retinol that is synthesized in hepatocytes and adipocytes (13). Increased levels of RBP-4 have been demonstrated in several metabolic conditions, including obesity, insulin resistance, polycystic ovary syndrome, and cardiovascular disease (14). Also, RBP-4 is believed to induce expression of enzymes involved in gluconeogenesis in hepatocytes and to impair insulin signaling pathways in skeletal muscle (15). Visfatin is predominantly secreted by visceral tissue; however, it is also found in skeletal muscle, liver, bone marrow, lymphocytes, and placenta (16). Visfatin promotes adipogenesis and exerts insulin-mimetic effects (17). It also upregulates production of proinflammatory cytokines by monocytes (18). Circulating levels of visfatin are increased in patients with type 1 and 2 DM and obesity (13,19). However, the association of visfatin with GDM is still unclear (20). Only a few adipokines have been investigated with respect to their involvement in GDM. Evidence in the existing literature does not support clear roles of chemerin, RBP-4, and visfatin in the prediction of GDM. In this study, we aimed to investigate the association of maternal serum levels of chemerin, RBP-4, visfatin, and insulin with GDM. Therefore, we performed a prospective cross-sectional study in pregnant women with GDM and with normal glucose tolerance. Material and Methods Study populationThis cross-sectional study was conducted in the Obstetrics and Gynecology Department of Hitit University between March 2015 and September 2015. The ethics committee of Ankara Numune Hospital approved the study, which was in accordance with the Declaration of Helsinki, 2013 Brazil version (20796219-724.131). All participants gave written informed consent for the study. The patients were 18 to 35 years of age and had singleton pregnancies. ...

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Section: Discussionsupporting

confidence: 44%

Are adipokines associated with gestational diabetes mellitus?

Görkem¹,

Küçükler²,

Toğrul³

et al. 2016

J Turkish German Gynecol Assoc

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“…A study conducted on nineteen pregnant females in their first trimester and thirty three in their last trimester showed that Chemerin levels gradually rose during pregnancy and were associated with both BMI and insulin resistance [17]. Another study conducted on Chinese pregnant females showed association of raised serum Chemerin with insulin resistance in obese subjects [18]. Contrary results are reported by Hare et al, as low Chemerin levels were observed in GDM pregnant females (n=nine) compared to normal pregnant women (n=eight).…”

Section: Discussionmentioning

confidence: 89%

Elevated levels of chemerin, leptin, and interleukin-18 in gestational diabetes mellitus

Fatima

Alam

Chaudhry

et al. 2016

The Journal of Maternal-Fetal & Neonatal Medicine

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“…Of the 494 articles that were retrieved, 20 were included in the meta-analysis; four were apelin studies [4,6,7,11], nine were chemerin studies [5,8,15,16,[23][24][25][26][27], five were omentin studies [28][29][30][31][32], one study involved both apelin and omentin [12], and one study involved both chemerin and omentin [33]. The 20 studies enrolled 2981 participants, of which 1493 were GDM patients and 1488 were healthy pregnant women (controls) [4-8, 11, 12, 15, 16, 23-33] (Fig.…”

Section: Literature Research and Characteristics Of The Included Studiesmentioning

confidence: 99%

Circulating apelin, chemerin and omentin levels in patients with gestational diabetes mellitus: a systematic review and meta-analysis

et al. 2020

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Background: The available data on the significance of circulating apelin, chemerin and omentin in women with gestational diabetes mellitus (GDM) are inconsistent. This analysis includes a systematic review of the evidence associating the serum concentrations of these adipokines with GDM. Methods: Publications through December 2019 were retrieved from PubMed, Embase, the Cochrane Library, and Web of Science. Subgroup analysis and meta-regression were conducted to evaluate sources of heterogeneity. Results: Analysis of 20 studies, including 1493 GDM patients and 1488 normal pregnant women did not find significant differences in circulating apelin and chemerin levels (apelin standardized mean difference [SMD] = 0.43, 95% confidence interval (CI): − 0.40 to 1.26, P = 0.31; chemerin SMD = 0.77, 95% CI − 0.07 to 1.61, P = 0.07). Circulating omentin was significantly lower in women with GDM than in healthy controls (SMD = − 0.72, 95% CI − 1.26 to − 0.19, P = 0.007). Publication bias was not found; sensitivity analysis confirmed the robustness of the pooled results. Conclusions: Circulating omentin was decreased in GDM patients, but apelin and chemerin levels were not changed. The results suggest that omentin has potential as a novel biomarker for the prediction and early diagnosis of GDM.

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Chemerin expression in Chinese pregnant women with and without gestational diabetes mellitus

Cited by 33 publications

References 35 publications

Are adipokines associated with gestational diabetes mellitus?

Are adipokines associated with gestational diabetes mellitus?

Elevated levels of chemerin, leptin, and interleukin-18 in gestational diabetes mellitus

Circulating apelin, chemerin and omentin levels in patients with gestational diabetes mellitus: a systematic review and meta-analysis

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