Elevated levels of chemerin, leptin, and interleukin-18 in gestational diabetes mellitus

Fatima, Syeda Sadia; Alam, Faiza; Chaudhry, Bushra; Khan, Taseer Ahmed

doi:10.1080/14767058.2016.1199671

Cited by 42 publications

(39 citation statements)

References 28 publications

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“…Increased IL18 levels were detected in women with GDM and correlated with maternal obesity [25]. Fatima et al found that increased IL18 levels in women with GDM were correlated with low-grade inflammation and insulin resistance [26]. IL18 gene polymorphisms have been investigated among patients with type 1 and type 2 diabetes [27][28][29][30][31].…”

Section: Discussionmentioning

confidence: 99%

IL16 and IL18 gene polymorphisms in women with gestational diabetes

Tarnowski

Wieczorek²,

Dziedziejko

et al. 2017

Ginekol Pol

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Objectives: Gestational diabetes mellitus is a carbohydrate intolerance that occurs during pregnancy. Various inflammatory mediators are considered to be risk factors leading to GDM development. Among them are pro-inflammatory cytokines, such as IL16 and IL18. The aim of this study was to examine the association between IL16 and IL18 polymorphisms and GDM. Material and methods:This study included 204 pregnant women with GDM and 207 pregnant women with normal glucose tolerance (NGT). All samples were genotyped in duplicate using allelic discrimination assays with TaqMan® probes.Results: We observed that there was a decreased frequency of IL16 rs4778889 CC genotype carriers among women with GDM (CC vs. CT + TT: OR = 0.14; 95% CI = 0.02-1.15; p = 0.034). However, there was no significant difference in the distribution of alleles (C vs. T: OR = 0.81; 95% CI = 0.54-1.21; p = 0.30). There was a decreased frequency of the IL18 rs187238 G allele among GDM women (G vs. C: OR = 0.71; 95% CI = 0.53-0.96; p = 0.027). We also observed a decreased frequency of the IL18 rs1946518 T allele among women with GDM; however, this difference had only borderline statistical significance. We observed an association between IL18 rs187238, rs1946518 and BMI in pregnant women. Conclusions:The results of this study suggest that IL18 rs187238 and rs1946518 polymorphisms may be associated with an increased risk of GDM as well as with BMI in pregnant women.

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Section: Discussionmentioning

confidence: 99%

IL16 and IL18 gene polymorphisms in women with gestational diabetes

Tarnowski

Wieczorek²,

Dziedziejko

et al. 2017

Ginekol Pol

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“…Of the 494 articles that were retrieved, 20 were included in the meta-analysis; four were apelin studies [4,6,7,11], nine were chemerin studies [5,8,15,16,[23][24][25][26][27], five were omentin studies [28][29][30][31][32], one study involved both apelin and omentin [12], and one study involved both chemerin and omentin [33]. The 20 studies enrolled 2981 participants, of which 1493 were GDM patients and 1488 were healthy pregnant women (controls) [4-8, 11, 12, 15, 16, 23-33] (Fig.…”

Section: Literature Research and Characteristics Of The Included Studiesmentioning

confidence: 99%

Circulating apelin, chemerin and omentin levels in patients with gestational diabetes mellitus: a systematic review and meta-analysis

et al. 2020

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Background: The available data on the significance of circulating apelin, chemerin and omentin in women with gestational diabetes mellitus (GDM) are inconsistent. This analysis includes a systematic review of the evidence associating the serum concentrations of these adipokines with GDM. Methods: Publications through December 2019 were retrieved from PubMed, Embase, the Cochrane Library, and Web of Science. Subgroup analysis and meta-regression were conducted to evaluate sources of heterogeneity. Results: Analysis of 20 studies, including 1493 GDM patients and 1488 normal pregnant women did not find significant differences in circulating apelin and chemerin levels (apelin standardized mean difference [SMD] = 0.43, 95% confidence interval (CI): − 0.40 to 1.26, P = 0.31; chemerin SMD = 0.77, 95% CI − 0.07 to 1.61, P = 0.07). Circulating omentin was significantly lower in women with GDM than in healthy controls (SMD = − 0.72, 95% CI − 1.26 to − 0.19, P = 0.007). Publication bias was not found; sensitivity analysis confirmed the robustness of the pooled results. Conclusions: Circulating omentin was decreased in GDM patients, but apelin and chemerin levels were not changed. The results suggest that omentin has potential as a novel biomarker for the prediction and early diagnosis of GDM.

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“…Leptin is increased in GDM 96,117,118 . Vaspin has also been documented to be increased in GDM by most authors who have studied this 119–121 , though a report of no association also exists 122 .…”

Section: Inflammatory Mediators: Parallels Between Gestational Diabetmentioning

confidence: 94%

“…Vaspin has also been documented to be increased in GDM by most authors who have studied this 119–121 , though a report of no association also exists 122 . Results of investigations into the association between serum chemerin and gestational diabetes have been mixed, with the majority of studies finding no effect 123–126 , while two studies reported an elevation 118,127 , and at least one small study described a reduction in chemerin among women with GDM 128 . Many of the above authors reported that obesity was a stronger determinant than GDM of serum chemerin.…”

Section: Inflammatory Mediators: Parallels Between Gestational Diabetmentioning

confidence: 99%

Roles of Inflammation and Depression in the Development of Gestational Diabetes

Robakis

Aasly

Williams

et al. 2017

Curr Behav Neurosci Rep

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Inflammation, the body’s response to harmful external agents, has long been found to be associated with depressive symptoms. The relationship between inflammation and depression is well established in the general population of people with depression, but is less so among perinatal women. Depression in the perinatal period is a common disorder, however available data do not indicate that there is a specific inflammatory picture associated with perinatal depression. We suggest that perinatal depression may be a heterogeneous construct, and that inflammation may be relevant to it in the context of other inflammatory morbidities of pregnancy. In this review we explore the available support for the hypothesis that inflammation associated with depression can represent a precipitating insult for the development of gestational diabetes, a known inflammatory morbidity of pregnancy.

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Elevated levels of chemerin, leptin, and interleukin-18 in gestational diabetes mellitus

Abstract: High chemerin and leptin levels are seen in GDM which may be associated with subclinical inflammation suggesting a role in development of insulin resistance.

Cited by 42 publications

References 28 publications

IL16 and IL18 gene polymorphisms in women with gestational diabetes

IL16 and IL18 gene polymorphisms in women with gestational diabetes

Circulating apelin, chemerin and omentin levels in patients with gestational diabetes mellitus: a systematic review and meta-analysis

Roles of Inflammation and Depression in the Development of Gestational Diabetes

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