Chelation therapy in cardiovascular disease: an update

Sultan, Sulaiman; Murarka, Shishir; Jahangir, Ahad; Mookadam, Farouk; Jahangir, Arshad

doi:10.1080/17512433.2017.1339601

Cited by 14 publications

(9 citation statements)

References 66 publications

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“…Chelation can reduce heavy metal burden in the body, and chelating agents, such as, desferrioxamine B for Fe overload and ethylenediaminetetraacetic acid (EDTA) or meso-2,3-dimercaptosuccinic acid (DMSA) for Hg toxicity, respectively (Ferrero 2016). Furthermore, chelation therapy is used offlabel to treat CVD (Sultan et al 2017). However, chelation therapies have side effects because they also chelate other essential ions like calcium or magnesium.…”

Section: Discussionmentioning

confidence: 99%

Reduction in Prevalence of Hypertension and Blood Heavy Metals among Curry-Consumed Korean

Choi

Shim

et al. 2018

Tohoku J. Exp. Med.

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Curcuma longa is rich in curcumin and used to treat disease and in food as a spice, especially in curry dishes. The objective of the present study was to determine whether curry intake reduces blood levels of heavy metals and hypertension (HTN) using Korean National Health and Nutrition Examination Survey 2013 data (n = 1,350). Study subjects (n = 1,350) were divided into two groups: 1) a curry intake group (n = 603), members of which had consumed a curry dish more than once a month over the previous year, and 2) a non-curry intake group (n = 747). Analysis showed the curry intake group had significantly lower heavy metal blood concentrations (Pb, Hg, and Cd) and blood concentrations of heavy metals were significantly associated with prevalence of HTN (P < 0.001 for Pb, Hg, and Cd). Curry intake also reduced the risk of HTN prevalence (odd ratios for curry intake vs. non-curry intake; Pb, 1.503 vs. 1.862; Hg, 1.112 vs. 1.149; Cd, 1.676 vs. 1.988). Logistic regression analysis was used to confirm the association between blood heavy metal levels and HTN. After adjusting for age, sex, lifetime smoking, and body mass index, the odd ratio of HTN was significant in the non-curry intake group, but not in the curry intake group, implying other factors influenced relations in the curry intake group. In view of the importance of curry consumption with reduced concentrations of heavy metals in blood and the prevalence of HTN, we suggest further well-designed clinical trials be conducted.

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Section: Discussionmentioning

confidence: 99%

Reduction in Prevalence of Hypertension and Blood Heavy Metals among Curry-Consumed Korean

Choi

Shim

et al. 2018

Tohoku J. Exp. Med.

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“…This chelating agent is used widely as a pharmaceutical excipient and as an anticoagulant for laboratory haematological tests. EDTA salts are administered intravenously to treat severe hypercalcaemia and heavy metal poisoning ( Sultan et al, 2017 ). It also has an antimicrobial effect that has led to its licensing as a lock solution for central venous lines in some countries ( Liu et al, 2018 ).…”

Section: Chelating Agentsmentioning

confidence: 99%

“…Systemic toxicity of EDTA is minimal when given appropriately ( Sultan et al, 2017 ). Ciliotoxicity is again minimal; in an embryonic chicken model, tracheal ciliary beating was inhibited by approximately 50% with 0.1% EDTA and this fully reversed when exposure ceased ( van de Donk et al, 1980 ).…”

Section: Chelating Agentsmentioning

confidence: 99%

Topical Antibiofilm Agents With Potential Utility in the Treatment of Chronic Rhinosinusitis: A Narrative Review

et al. 2022

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The role of bacterial biofilms in chronic and recalcitrant diseases is widely appreciated, and the treatment of biofilm infection is an increasingly important area of research. Chronic rhinosinusitis (CRS) is a complex disease associated with sinonasal dysbiosis and the presence of bacterial biofilms. While most biofilm-related diseases are associated with highly persistent but relatively less severe inflammation, the presence of biofilms in CRS is associated with greater severity of inflammation and recalcitrance despite appropriate treatment. Oral antibiotics are commonly used to treat CRS but they are often ineffective, due to poor penetration of the sinonasal mucosa and the inherently antibiotic resistant nature of bacteria in biofilms. Topical non-antibiotic antibiofilm agents may prove more effective, but few such agents are available for sinonasal application. We review compounds with antibiofilm activity that may be useful for treating biofilm-associated CRS, including halogen-based compounds, quaternary ammonium compounds and derivatives, biguanides, antimicrobial peptides, chelating agents and natural products. These include preparations that are currently available and those still in development. For each compound, antibiofilm efficacy, mechanism of action, and toxicity as it relates to sinonasal application are summarised. We highlight the antibiofilm agents that we believe hold the greatest promise for the treatment of biofilm-associated CRS in order to inform future research on the management of this difficult condition.

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“…Rationale and data in the chelation therapy on cardiovascular diseases 134 Clarifying the role of the treatment with EDTA for prevention of cardiovascular disease 135 Effect of chelation therapy on cardiovascular disease 136 Malaria Synthesis of four different metal complexes with potential malaria activity 10…”

Section: Cardiovascularmentioning

confidence: 99%

An overview on ligands of therapeutically interest

Martin¹,

Alés²,

Asuero³

2018

PPIJ

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The principles governing metal-ligand complex stability and specificity depend on the properties of both the metal and the chelating agent. The exploration of coordination chemistry offers the real prospects of providing new understanding of intractable diseases and of devising novel therapeutics and diagnosis agents. Refinement in the approach to chelator design has come with a more subtle understanding of binding kinetics, catalytic mechanisms and donor interactions. Ligands that effectively bind metal ions and also include specific features to enhance targeting, reporting, and overall efficacy are driving innovation in areas of disease, diagnosis and therapy. In this contribution the topics of bioinorganic medicinal chemistry, chelating agents in the treatment of metallic ion overload in the body, and expanding the notion of chelating agent in medicine are successively dealt with, paying then attention to platinum, gold, iron, copper and aluminium ion metal complexes having medicinal interest. A tabular summary containing selected applications of ligands and complexes of therapeutic interest is also shown to including the most relevant and current bibliography. A number of papers concerning miscellaneous topics based on selected key words are also tabulated. Metal chelation principles offer wide new opportunities in the drug design field in addition to the classical answer of metal sequestration or elimination.

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Chelation therapy in cardiovascular disease: an update

Cited by 14 publications

References 66 publications

Reduction in Prevalence of Hypertension and Blood Heavy Metals among Curry-Consumed Korean

Reduction in Prevalence of Hypertension and Blood Heavy Metals among Curry-Consumed Korean

Topical Antibiofilm Agents With Potential Utility in the Treatment of Chronic Rhinosinusitis: A Narrative Review

An overview on ligands of therapeutically interest

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