Reduction in Prevalence of Hypertension and Blood Heavy Metals among Curry-Consumed Korean

Choi, Jo-Woong; Oh, Chorong; Shim, Sun-Yup; Jeong, Su-Youn; Kim, Hyung Sik; Kim, Min-Sun

doi:10.1620/tjem.244.219

Cited by 6 publications

(5 citation statements)

References 53 publications

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“…Curcumin has been used not only for cooking but also in traditional medicine. It is known to be useful in various conditions, including cardiovascular health, cognitive function, and cancer treatment [ 36 – 38 ].…”

Section: Resultsmentioning

confidence: 99%

Overcoming P‐Glycoprotein‐Mediated Multidrug Resistance in Colorectal Cancer: Potential Reversal Agents among Herbal Medicines

Lee

Joung

Cho

et al. 2018

Evidence-Based Complementary and Alternative Medicine

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Objectives Multidrug resistance (MDR) is the major reason for the failure of chemotherapy in colorectal cancer (CRC), and the primary determinant of MDR in CRC patients is active drug efflux owing to overexpression of P-glycoprotein (P-gp) in cancer tissues. Despite research efforts to overcome P-gp-mediated drug efflux, the high toxicity of P-gp inhibitors has been a major obstacle for the clinical use of these agents. The aim of this study was to review the literature for potential P-gp reversal agents among traditional herbal medicines, which offer the advantages of safety and potential synergetic effects in CRC chemotherapy. Methods We searched ten databases including 3 English databases, 1 Chinese medical database, and 6 Korean medical databases up to July 2018 and included in vivo and in vitro studies evaluating the effects of herbal medicines as P-gp reversal agents in CRC. Results A total of 28 potentially related studies were identified and 16 articles were included. Involving 3 studies about Salvia miltiorrhiza and 2 studies about Curcuma longa, finally we found 14 kinds of traditional herbal medicines—Salvia miltiorrhiza, Curcuma longa, Sinomenium acutum, Stephania tetrandra, Bufo gargarizans, Coptis japonica, Piper nigrum and Piper longum, Hedyotis diffusa, Schisandra chinensis, Glycyrrhiza glabra, Glycyrrhiza inflate, Daphne genkwa, Stemona tuberosa Lour, and Andrographis paniculata—as showing efficacy as P-gp inhibitors in anticancer drug-resistant CRC cells in vitro and in vivo. Conclusions This brief account provides insight into the relationship between P-gp and CRC. Further studies on herbal medicines with demonstrated effects against P-gp overexpression will aid in improving the efficacy of chemotherapy in CRC.

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Section: Resultsmentioning

confidence: 99%

Overcoming P‐Glycoprotein‐Mediated Multidrug Resistance in Colorectal Cancer: Potential Reversal Agents among Herbal Medicines

Lee

Joung

Cho

et al. 2018

Evidence-Based Complementary and Alternative Medicine

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“…Eating curry lowered the risk of HTN development as well. We recommend conducting more painstakingly planned clinical trials due to the prevalence of HTN and the link between consuming curry and having lower blood levels of heavy metals [ 14 ].…”

Section: Resultsmentioning

confidence: 99%

Effect of curry leaves in lowering blood pressure among hypertensive Indian patients

Gopal

2023

Bioinformation

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Hypertension, commonly known as high or rising blood pressure, is characterized by a consistently elevated blood arterial pressure. It is a significant medical condition called hypertension raises your risk of developing problems with your heart, brain, kidneys, and other organs. Curry leaves work well as a treatment for high blood pressure. Curry leaves are thought to have a potent therapeutic impact for the treatment of high blood pressure since they are low in salt and high in potassium. Therefore, it is of interest to reduce the level of blood pressure among adults in rural area with the help of curry leaves. According to the statistical analysis, the experimental group's post-test mean score for hypertension was 155 with a standard deviation of 13.892 while the control group's post-test mean score was 162 with a standard deviation of 17.20. The estimated unpaired value of t = 11.07 was deemed to be statistically significant at the p 0.05 level and the mean difference was 7. As a result, the null hypothesis was rejected and the research hypothesis was accepted. Giving Curry leaf powder to patients with hypertension as a consequence was an effective intervention.

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“…A study in mice showed that Cd administration with curcumin resulted in lower Cd levels in the blood and organs (liver, kidney) than in mice that received Cd only [74,75]. Regular consumption of curcumin was linked to lowered blood Cd and lowered risk of hypertension in a Korean study [76].…”

Section: Dietary Factors: Diet Qualitymentioning

confidence: 98%

Toxicity Tolerance in the Carcinogenesis of Environmental Cadmium

Cirovic,

Satarug

2024

IJMS

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Cadmium (Cd) is an environmental toxicant of worldwide public health significance. Diet is the main non-workplace Cd exposure source other than passive and active smoking. The intestinal absorption of Cd involves transporters for essential metals, notably iron and zinc. These transporters determine the Cd body burden because only a minuscule amount of Cd can be excreted each day. The International Agency for Research on Cancer listed Cd as a human lung carcinogen, but the current evidence suggests that the effects of Cd on cancer risk extend beyond the lung. A two-year bioassay demonstrated that Cd caused neoplasms in multiple tissues of mice. Also, several non-tumorigenic human cells transformed to malignant cells when they were exposed to a sublethal dose of Cd for a prolonged time. Cd does not directly damage DNA, but it influences gene expression through interactions with essential metals and various proteins. The present review highlights the epidemiological studies that connect an enhanced risk of various neoplastic diseases to chronic exposure to environmental Cd. Special emphasis is given to the impact of body iron stores on the absorption of Cd, and its implications for breast cancer prevention in highly susceptible groups of women. Resistance to cell death and other cancer phenotypes acquired during Cd-induced cancer cell transformation, under in vitro conditions, are briefly discussed. The potential role for the ZnT1 efflux transporter in the cellular acquisition of tolerance to Cd cytotoxicity is highlighted.

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Reduction in Prevalence of Hypertension and Blood Heavy Metals among Curry-Consumed Korean

Cited by 6 publications

References 53 publications

Overcoming P‐Glycoprotein‐Mediated Multidrug Resistance in Colorectal Cancer: Potential Reversal Agents among Herbal Medicines

Overcoming P‐Glycoprotein‐Mediated Multidrug Resistance in Colorectal Cancer: Potential Reversal Agents among Herbal Medicines

Effect of curry leaves in lowering blood pressure among hypertensive Indian patients

Toxicity Tolerance in the Carcinogenesis of Environmental Cadmium

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