Chelation of cadmium by combining deferasirox and deferiprone in rats

Abstract

The present research aimed to characterize the potential efficiency of two chelators after cadmium administration for 60 days following two dose levels of 20 and 40 mg/kg body weight daily to male rats. However, the hypothesis that the two chelators might be more efficient as combined therapy than as single therapy in removing cadmium from the body was considered. In this way, two known chelators deferasirox and deferiprone (L(1)) were chosen and tested in the acute rat model. Two chelators were given orally as a single or combined therapy for the period of a week. Cadmium and iron concentrations in various tissues were determined by graphite furnace and flame atomic absorption spectrometry methods, respectively. The combined chelation therapy results show that Deferasirox and L(1) are able to remove cadmium ions from the body while iron concentration returned to the normal level and symptoms are also decreased.

Combined Chelation Therapy With Deferasirox and Desferrioxamine in Removing Lead From Rats

“…From pervious results that reported by Fatemi. Amiri et al (2007); Tubafard and Fatemi (2008) and Fatemi et al (2011; and our present results, it can be concluded that two chelators (DFX+ DFO) are more effective as combined therapy than single therapy in removal of lead from the body. Therefore, DFX +DFO combination seems to be a promising drug of lead-mobilizing agent.…”

“…Recent studies with chelators that have different lipophilic properties as combined therapy have shown favorable efficacy to mobilize mercury and cadmium (Tubafard et al, 2010). Results of this kind of combined chelation therapy has been proved by Fatemi et al (2009); Amiri et al (2007); Tubafard and Fatemi (2008); Tubafard et al (2010); Fatemi et al, (2011; and Iranmanesh et al (2013). The aim of this study was to investigate the chelating potency of DFX and DFO.…”

“…These chelating agents promote the excretion and subsequent depletion of the transition metal in biological systems (Tubafard et al, 2010). These chelating agents consist of a range of bidentate, tridentate and hexadentate ligands in which two, three or six atoms are able to coordinate, respectively (Fatemi et al, 2011). Clinical evaluations of some chelators for removal of toxic metal in rats have been previously reported (Amiri et al, 2007;Fatemi et al, 2009;Saljooghi and Fatemi, 2010;.…”

Chelation of Thallium (III) in Rats Using Combined Deferasirox and Deferiprone Therapy

“…In addition, iron concentration after chelation therapy significantly increased, and returned to its normal state. From previous studies ( 26 – 29 ) and trial results, it can be concluded that the two chelators (DFX + L1) were more effective as a combined therapy than as single-agent therapies in the removal of thallium from the body. Therefore, the DFX + L1 combination can be considered for preliminary testing as chelation therapy in thallium toxicity cases.…”

Neuroprotective Effects of Tea Against Cadmium Toxicity

“…Given that the risk of human exposure to Cd is persistently growing due to its prevalence in the environment and the absence of decomposable processes [34], there is a strong impetus to develop effective therapeutic strategies for managing Cd toxicity. While there is no consensus on the efficiency of chelating therapy for Cd induced toxicity, some scholars hold the view that Cd chelation may well intensify its elimination, thus reducing its toxic effects [35,36]. Interestingly, the co-administration of chelating agents and antioxidants has been associated with better effects compared to administration of each molecule individually [37].…”