Checkerboard reversal pattern and flash VEPs in dialysed and non-dialysed subjects

Effect of haemodialysis on visual‐evoked potential parameters

“…stated that: VEP is only one of a possible universe of measures that may provide quantitative information about the degree of renal insufficiency, and in uraemic patients, the VEP parameters may differ from standard values and may change with varying clinical conditions 4,5 . Prolonged latency of visual evoked potentials (VEP) to both flash 1,5 , 6 and pattern reversal 4,7 , 8 visual stimuli has been demonstrated in uraemic patients by several authors. Even though some previous reports signalled that the latencies of VEP's of patients maintained on chronic haemodialysis seldom return to the normal range of values, 1 in our group, that was not the case.…”

“…Prolonged latency of visual evoked potentials (VEP) to both flash 1,5 , 6 and pattern reversal 4,7 , 8 visual stimuli has been demonstrated in uraemic patients by several authors. Even though some previous reports signalled that the latencies of VEP's of patients maintained on chronic haemodialysis seldom return to the normal range of values, 1 in our group, that was not the case. When we analysed the group as a whole, VEP parameters, just before the dialytic treatment, were significantly different from those of normal controls.…”

“…Many authors have hypothesed the existence of unknown neurotoxins, which could damage both the axonal membrane and synaptic mechanism. As patients with severe azotemia may deteriorate in an unpredictable manner, it is desirable to institute dialysis before patients develop advanced symptoms of uraemia 1 . Evoked potentials, (EP) like VEP (visual evoked potential), provide objective information on the functional integrity of CNS structures and find their greatest clinical use in the diagnosis of demyelinating, brainstem or sensory organ disease 2 .…”

“…Evoked potentials, (EP) like VEP (visual evoked potential), provide objective information on the functional integrity of CNS structures and find their greatest clinical use in the diagnosis of demyelinating, brainstem or sensory organ disease 2 . Different papers have emphasized the presence of VEP abnormalities in metabolic disorders including CRF 1 …”

Central and peripheral involvement in hemodialysed subjects: Neurophysiological and nephrological relationships

“…The reduction in common peroneal MCV seems to indicate that demyelination is not the most important pathogenetic event in this neuropathy, although it may be present secondarily, as morphological data have shown [13]. Rossini [3] noted a significantly altered latency only at the higher spatial stimulation frequencies, sizes 15' and 30' index of elective involvement of the papillomacular bundle. The VEP latencies show serious CNS involvement in the patients, even when there was no clinical manifestation.…”