Chaya (Jatropha tanjorensis) leafs protect against sodium benzoate mediated renal dysfunction and hepatic damage in rats

Oladele, Johnson Olaleye; Oladele, Oluwaseun Titilope; Ademiluyi, Adedayo O.; Oyeleke, Oyedotun M.; Awosanya, Olaide O.; Oyewole, Olu Israel

doi:10.1186/s40816-020-00160-5

Cited by 27 publications

(16 citation statements)

References 32 publications

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“…Numerous plants that grow in Nigeria are well-known to have countless therapeutic potentials that could be due to their antioxidant properties ( Oladele et al., 2020b , c ). Plants are known to be the main source of natural antioxidants in the form of phenolic compounds (phenolic acids, flavonoids and polyphenols) ( Table 3 ).…”

Section: Medicinal Plants With Pharmacological and Biological Action mentioning

confidence: 99%

“…Plants are known to be the main source of natural antioxidants in the form of phenolic compounds (phenolic acids, flavonoids and polyphenols) ( Table 3 ). Most of the anti-inflammatory, digestive, neuroprotective, hepatoprotective and nephroprotective drugs derived from natural origin have been reported to have antioxidant/radical scavenging mechanism as part of their activity ( Oladele et al., 2020b , c ; Oyewole et al., 2017 ). The ingestion of natural antioxidants has been associated with the reduced risk of cancer, cardiovascular disease, diabetes and other diseases associated with ageing ( Ajayi et al., 2017 ).…”

Section: Medicinal Plants With Pharmacological and Biological Action mentioning

confidence: 99%

“…A vast number of indigenous plants in Nigeria have been reported to reveal antioxidant activity, including Allium sativum, Zingiber officinale, Crocus sativus, Dodonaea viscose, Barlerianoctiflora, Anacardium occidentale, Datura fastuosa, Caesalpiniabonducella and many more as in Table 3 . Several of these antioxidants from plants has been shown to be an active oxygen scavengers or free radicals, with have no any harmful effect on human body ( Oyewole et al., 2017 ; Oladele et al., 2020b , c ; Farombi et al., 2019 ). For detrimental effects of reactive oxygen species to be stopped, plants have shown a powerfully in-built enzymatic and non-enzymatic scavenging capacity.…”

Section: Medicinal Plants With Pharmacological and Biological Action mentioning

confidence: 99%

“…Consistent eating of dietary foods like fruits and vegetables is well documented to have potentials in the management of various chronic ailments affecting human in Africa. These supplements of antioxidant are directly being obtained from fresh fruits and vegetables, which contain a vast quantity of alkaloids, flavonoids and antioxidant complements which can take part in the defense mechanisms against different cardiovascular ailments including different types of cancers and many health problems ( Oladele et al., 2020a , b ; Ajayi et al., 2017 ).…”

Section: Medicinal Plants With Pharmacological and Biological Action mentioning

confidence: 99%

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A systematic review on COVID-19 pandemic with special emphasis on curative potentials of Nigeria based medicinal plants

Oladele¹,

Ajayi

Oyeleke³

et al. 2020

Heliyon

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Despite the frightening mortality rate associated with COVID-19, there is no known approved drug to effectively combat the pandemic. COVID-19 clinical manifestations include fever, fatigue, cough, shortness of breath, and other complications. At present, there is no known effective treatment or vaccine that can mitigate/inhibit SARS-CoV-2. Available clinical intervention for COVID-19 is only palliative and limited to support. Thus, there is an exigent need for effective and non-invasive treatment. This article evaluates the possible mechanism of actions of SARS-CoV-2 and present Nigeria based medicinal plants which have pharmacological and biological activities that can mitigate the hallmarks of the pathogenesis of COVID-19. SARS-CoV-2 mode of actions includes hyper-inflammation characterized by a severe and fatal hyper-cytokinaemia with multi-organ failure; immunosuppression; reduction of angiotensin-converting enzyme 2 (ACE2) to enhance pulmonary vascular permeability causing damage to the alveoli; and further activated by open reading frame (ORF)3a, ORF3b, and ORF7a via c-Jun N- terminal kinase (JNK) pathway which induces lung damage. These mechanisms of action of SARS-CoV-2 can be mitigated by a combination therapy of medicinal herbs based on their pharmacological activities. Since the clinical manifestations of COVID-19 are multifactorial with co-morbidities, we strongly recommend the use of combined therapy such that two or more herbs with specific therapeutic actions are administered to combat the mediators of the disease.

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Section: Medicinal Plants With Pharmacological and Biological Action mentioning

confidence: 99%

Section: Medicinal Plants With Pharmacological and Biological Action mentioning

confidence: 99%

Section: Medicinal Plants With Pharmacological and Biological Action mentioning

confidence: 99%

Section: Medicinal Plants With Pharmacological and Biological Action mentioning

confidence: 99%

See 2 more Smart Citations

A systematic review on COVID-19 pandemic with special emphasis on curative potentials of Nigeria based medicinal plants

Oladele¹,

Ajayi

Oyeleke³

et al. 2020

Heliyon

View full text Add to dashboard Cite

show abstract

“…Therefore, the discovery of novel, noninvasive, and nontoxic drug candidates that will effectively mitigate mucosal inflammation is required. Medicinal plants are used since time immemorial in the treatment of various diseases due to their accessibility, inexpensive natural products, and host a broad range of both biologically and chemically active phytocompounds which have been used in the synthesis of therapeutic drugs (Oladele et al., 2017a, 2017d; Oladele, Ajayi, Oyeleke, Oladele, Olowookere, Adeniyi, & Oyewole, 2020; Oladele, Oladele, et al., 2020; Oladele, Oyeleke, Oladele, et al., 2020; Oyewole et al., 2016, 2017). Telfairia occidentalis is a medicinal plant with a number of claimed pharmacological activities (Oladele et al., 2017b, 2017c; Oladele, Oyeleke, Awosanya, et al., 2020; Oladele, Bamigboye, et al., 2020).…”

Section: Introductionmentioning

confidence: 99%

Telfairia occidentalis mitigates dextran sodium sulfate‐induced ulcerative colitis in rats via suppression of oxidative stress, lipid peroxidation, and inflammation

Oladele¹,

Anyim²,

Oyeleke³

et al. 2021

J Food Biochem

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Ulcerative colitis (UC), a subcategory of inflammatory bowel diseases, affects more than 2 million people globally. This study sought to investigate the curative ability of aqueous leaf extract of Telfairia occidentalis (ATO) on dextran sodium sulfate (DSS)‐mediated colitis in rats. UC was induced by 5% of DSS in drinking water, and the curative ability of ATO was assessed at 200 mg/kg by oral administration for 10 days. The effect of ATO was deduced on anti‐inflammatory, preclinical features [disease activity index (DAI)], redox assays, and alterations both microscopic and macroscopic of the colonic mucosa. DSS mediated inflammation in colons of rats with a significant increase in nitric oxide, myeloperoxidase, IL‐1β, IL‐6, and TNF‐α levels compared with a control group. Lipid peroxidation was also induced following exposure of rats to DSS. There is a marked decrease in antioxidant enzymes activities in DSS group. However, treatment with ATO markedly inhibited the colonic inflammation by reversing the elevated levels of inflammatory markers. Furthermore, ATO suppressed the lipid peroxidation chain reaction by reducing the level of malondialdehyde and hydrogen peroxide. ATO attenuates DSS‐induced oxidative stress by increase the level of GSH and enhancing the activities of the cytoprotective enzymes (catalase, glutathione‐S‐transferase, and superoxide dismutase). Taken together, ATO reduced DAI score, inhibited inflammation, suppressed lipid peroxidation, attenuated oxidative stress, and enhanced the antioxidant enzymes activities. These therapeutic effects of ATO might be due to its phytochemicals as showed in gas chromatography‐mass spectroscopy results. The findings of this study indicate that aqueous leaf extract of T. occidentalis has could be a drug candidate for the treatment of UC. Practical applications The study focused on the curative ability of aqueous leaf extract of Telfairia occidentalis on dextran sodium sulfate (DSS) mediated colitis in rats. The extract elicits beneficial effects against colitis via its ability to reduce mucosal inflammation, suppress lipid peroxidation, attenuate oxidative stress, enhance the antioxidant enzymes activities, and reduce both infiltration of inflammatory cells and mucosal damage in colon. This study provides scientific evidence to the therapeutic ability of aqueous leaf extract of T. occidentalis in the treatment of DSS‐induced ulcerative colitis and could be a drug candidate for the treatment of inflammatory bowel diseases in humans.

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Protective role of the dandelion extract against the blood–liver axis, cell membranes, and anemia disorder in sodium benzoate‐exposed rats

Suljević

Mitrašinović-Brulić

Dervišević

et al. 2022

Cell Biochemistry & Function

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Sodium benzoate (SB) as an additive in various food products prevents the growth of microbes. Although SB is considered safe, many studies have reported adverse effects. The aim of this study was to investigate the effect of dandelion extract on cell damage and hematological and biochemical disorders induced by SB in male albino rats. Different doses of SB (200 and 600 mg/kg) and ethanolic dandelion root extract (D) (40 mg/kg) were used in a 2-week treatment of rats. Rat mortality and a higher frequency of behavioral alterations such as apathy, anxiety, and aggression have been reported at a higher dose of SB. Changes in urine pH, proteinuria, nitrituria, and bilirubinemia caused by SB were regulated by adding dandelion extract. Analysis of specific serum and urine parameters, as well as microscopic analysis of hepatocytes, showed liver and kidney failure. Anemia associated with hemolytic disorder due to erythrocyte impaired the presence of acanthocytes, and decreased values of erythrocyte blood count, hemoglobin concentration, average red blood cell size, hemoglobin amount per red blood cell, and mean corpuscular hemoglobin concentration were caused by SB treatment. As a dietary supplement, dandelion extract can be useful in the prevention of SB-induced liver and kidney injury, and also a remedy against induced anemia, neutropenia, thrombocytopenia, hyperproteinemia, hyperglycemia, and reduction of inflammatory responses.

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Chaya (Jatropha tanjorensis) leafs protect against sodium benzoate mediated renal dysfunction and hepatic damage in rats

Cited by 27 publications

References 32 publications

A systematic review on COVID-19 pandemic with special emphasis on curative potentials of Nigeria based medicinal plants

A systematic review on COVID-19 pandemic with special emphasis on curative potentials of Nigeria based medicinal plants

Telfairia occidentalis mitigates dextran sodium sulfate‐induced ulcerative colitis in rats via suppression of oxidative stress, lipid peroxidation, and inflammation

Protective role of the dandelion extract against the blood–liver axis, cell membranes, and anemia disorder in sodium benzoate‐exposed rats

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