Protective role of the dandelion extract against the blood–liver axis, cell membranes, and anemia disorder in sodium benzoate‐exposed rats

Abstract

Sodium benzoate (SB) as an additive in various food products prevents the growth of microbes. Although SB is considered safe, many studies have reported adverse effects. The aim of this study was to investigate the effect of dandelion extract on cell damage and hematological and biochemical disorders induced by SB in male albino rats. Different doses of SB (200 and 600 mg/kg) and ethanolic dandelion root extract (D) (40 mg/kg) were used in a 2-week treatment of rats. Rat mortality and a higher frequency of behavioral alterations such as apathy, anxiety, and aggression have been reported at a higher dose of SB. Changes in urine pH, proteinuria, nitrituria, and bilirubinemia caused by SB were regulated by adding dandelion extract. Analysis of specific serum and urine parameters, as well as microscopic analysis of hepatocytes, showed liver and kidney failure. Anemia associated with hemolytic disorder due to erythrocyte impaired the presence of acanthocytes, and decreased values of erythrocyte blood count, hemoglobin concentration, average red blood cell size, hemoglobin amount per red blood cell, and mean corpuscular hemoglobin concentration were caused by SB treatment. As a dietary supplement, dandelion extract can be useful in the prevention of SB-induced liver and kidney injury, and also a remedy against induced anemia, neutropenia, thrombocytopenia, hyperproteinemia, hyperglycemia, and reduction of inflammatory responses.

Impact of dietary supplementation with chokeberry (Aronia melanocarpa, Michx.) on tetrachloride‐induced liver injury in Wistar rats: Hematological and biochemical implication

“…Manzamines and Artemisinic acid are used as antimalarial drugs, 6 bioactive components from ginseng (Panax ginseng) are used as an antiproliferative drug against breast cancer cells (MCF-7), 7 and dandelion root extract showed better effects against hepatorenal injury. 8 Aronia melanocarpa (AM) is a medicinal plant native to North America. Its fruits are rich in antioxidants such as anthocyanins, procyanidins, phenolic acids, catechins, and flavonoids, as well as vitamins and bioelements.…”

“…A wide range of plants and their active components are known in medical research. Manzamines and Artemisinic acid are used as antimalarial drugs, 6 bioactive components from ginseng ( Panax ginseng ) are used as an antiproliferative drug against breast cancer cells (MCF‐7), 7 and dandelion root extract showed better effects against hepatorenal injury 8 …”