Charting Cognitive and Volumetric Trajectories after Stroke: Protocol for the Cognition and Neocortical Volume after Stroke (CANVAS) Study

Brodtmann, Amy; Werden, Emilio; Pardoe, Heath R.; Li, Qi; Jackson, Graeme D.; Donnan, Geoffrey A.; Cowie, Tiffany; Bradshaw, Jennifer; Darby, David; Cumming, Toby

doi:10.1111/ijs.12301

Cited by 47 publications

(55 citation statements)

References 34 publications

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“…(2016) [22]Cognition and Neocortical Volume After Stroke (CANVAS)Australia2014–20181351m, 3m, 1y, 3y3 mo, 1 y, 3 yInitial, 3 mo, 1 y, 3 yDSM, NINDS-AIRENBrodtmann et al. (2014) [23]Cognitive Function After Stroke (CogFAST-UK)UK2002–20123553m; 1–8y (annually)3 mo; 1–8 y (annually)3 mo, 2 yYesAllan et al. (2011) [12]Cognitive Function After Stroke Nigeria (CogFAST-Nigeria)Nigeria2010–ongoing2173m3 mo3 mo (small subset only)DSM-IV, AHA/ASAAkinyemi et al.…”

Section: Methodsmentioning

confidence: 99%

STROKOG (stroke and cognition consortium): An international consortium to examine the epidemiology, diagnosis, and treatment of neurocognitive disorders in relation to cerebrovascular disease

Sachdev

Crawford

et al. 2016

Alz & Dem Diag Ass & Dis Mo

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IntroductionThe Stroke and Cognition consortium (STROKOG) aims to facilitate a better understanding of the determinants of vascular contributions to cognitive disorders and help improve the diagnosis and treatment of vascular cognitive disorders (VCD).MethodsLongitudinal studies with ≥75 participants who had suffered or were at risk of stroke or TIA and which evaluated cognitive function were invited to join STROKOG. The consortium will facilitate projects investigating rates and patterns of cognitive decline, risk factors for VCD, and biomarkers of vascular dementia.ResultsCurrently, STROKOG includes 25 (21 published) studies, with 12,092 participants from five continents. The duration of follow-up ranges from 3 months to 21 years.DiscussionAlthough data harmonization will be a key challenge, STROKOG is in a unique position to reuse and combine international cohort data and fully explore patient level characteristics and outcomes. STROKOG could potentially transform our understanding of VCD and have a worldwide impact on promoting better vascular cognitive outcomes.

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Section: Methodsmentioning

confidence: 99%

STROKOG (stroke and cognition consortium): An international consortium to examine the epidemiology, diagnosis, and treatment of neurocognitive disorders in relation to cerebrovascular disease

Sachdev

Crawford

et al. 2016

Alz & Dem Diag Ass & Dis Mo

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“…The tasks used to measure each cognitive domain are listed in Table 2. This protocol has been modelled on that validated by the CANVAS study, a longitudinal study of patients after stroke [36]. All tasks are designed for serial testing and are less affected by practice effects.…”

Section: Methodsmentioning

confidence: 99%

Does left ventricular hypertrophy affect cognition and brain structural integrity in type 2 diabetes? Study design and rationale of the Diabetes and Dementia (D2) study

et al. 2017

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BackgroundCognitive impairment is common in type 2 diabetes mellitus, and there is a strong association between type 2 diabetes and Alzheimer’s disease. However, we do not know which type 2 diabetes patients will dement or which biomarkers predict cognitive decline. Left ventricular hypertrophy (LVH) is potentially such a marker. LVH is highly prevalent in type 2 diabetes and is a strong, independent predictor of cardiovascular events. To date, no studies have investigated the association between LVH and cognitive decline in type 2 diabetes. The Diabetes and Dementia (D2) study is designed to establish whether patients with type 2 diabetes and LVH have increased rates of brain atrophy and cognitive decline.MethodsThe D2 study is a single centre, observational, longitudinal case control study that will follow 168 adult patients aged >50 years with type 2 diabetes: 50% with LVH (case) and 50% without LVH (control). It will assess change in cardiovascular risk, brain imaging and neuropsychological testing between two time-points, baseline (0 months) and 24 months. The primary outcome is brain volume change at 24 months. The co-primary outcome is the presence of cognitive decline at 24 months. The secondary outcome is change in left ventricular mass associated with brain atrophy and cognitive decline at 24 months.DiscussionThe D2 study will test the hypothesis that patients with type 2 diabetes and LVH will exhibit greater brain atrophy than those without LVH. An understanding of whether LVH contributes to cognitive decline, and in which patients, will allow us to identify patients at particular risk.Trial registrationAustralian New Zealand Clinical Trials Registry (ACTRN12616000546459), date registered, 28/04/2016Electronic supplementary materialThe online version of this article (doi:10.1186/s12902-017-0173-7) contains supplementary material, which is available to authorized users.

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“…In the Cognition and Neocortical Volume After Stroke (CANVAS) study, 11 we examine structural MRI markers of brain aging (hippocampal volume, total brain volume, cortical thickness, white matter hyperintensity [WMH]) 8 volume in prospectively recruited ischemic stroke patients scanned within 6 weeks after stroke (25.5 ± 9.2 [7–42] days). We compare their results with results from age-matched controls who underwent identical scanning.…”

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Structural MRI markers of brain aging early after ischemic stroke

Werden

Cumming

et al. 2017

Neurology

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Objective:To examine associations between ischemic stroke, vascular risk factors, and MRI markers of brain aging.Methods:Eighty-one patients (mean age 67.5 ± 13.1 years, 31 left-sided, 61 men) with confirmed first-ever (n = 66) or recurrent (n = 15) ischemic stroke underwent 3T MRI scanning within 6 weeks of symptom onset (mean 26 ± 9 days). Age-matched controls (n = 40) completed identical testing. Multivariate regression analyses examined associations between group membership and MRI markers of brain aging (cortical thickness, total brain volume, white matter hyperintensity [WMH] volume, hippocampal volume), normalized against intracranial volume, and the effects of vascular risk factors on these relationships.Results:First-ever stroke was associated with smaller hippocampal volume (p = 0.025) and greater WMH volume (p = 0.004) relative to controls. Recurrent stroke was in turn associated with smaller hippocampal volume relative to both first-ever stroke (p = 0.017) and controls (p = 0.001). These associations remained significant after adjustment for age, sex, education, and, in stroke patients, infarct volume. Total brain volume was not significantly smaller in first-ever stroke patients than in controls (p = 0.056), but the association became significant after further adjustment for atrial fibrillation (p = 0.036). Cortical thickness and brain volumes did not differ as a function of stroke type, infarct volume, or etiology.Conclusions:Brain structure is likely to be compromised before ischemic stroke by vascular risk factors. Smaller hippocampal and total brain volumes and increased WMH load represent proxies for underlying vascular brain injury.

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Charting Cognitive and Volumetric Trajectories after Stroke: Protocol for the Cognition and Neocortical Volume after Stroke (CANVAS) Study

Cited by 47 publications

References 34 publications

STROKOG (stroke and cognition consortium): An international consortium to examine the epidemiology, diagnosis, and treatment of neurocognitive disorders in relation to cerebrovascular disease

STROKOG (stroke and cognition consortium): An international consortium to examine the epidemiology, diagnosis, and treatment of neurocognitive disorders in relation to cerebrovascular disease

Does left ventricular hypertrophy affect cognition and brain structural integrity in type 2 diabetes? Study design and rationale of the Diabetes and Dementia (D2) study

Structural MRI markers of brain aging early after ischemic stroke

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