We perform global fits to the moments of semileptonic B-decay distributions and extract jV cb j, the heavy quark masses, and the nonperturbative parameters of the heavy quark expansion. We include next-to-nextto-leading-order perturbative corrections and recent determinations of the charm mass and discuss how they improve the precision of the global fit. In particular, using the m c determination of Chetyrkin et al. [Phys. Rev. D80, 074010 (2009)], we get m kin b ¼ 4.541ð23Þ GeV and jV cb j ¼ ð42:42 AE 0.86Þ × 10 −3 . We also discuss the implications of the new fits for the normalization of rare B decays, the zero-recoil sum rule in B → D Ã lν, and the inclusive determination of jV ub j.