Charlotte Brontë

Lodge, Sara

doi:10.1007/978-1-137-08603-7

Cited by 4 publications

(2 citation statements)

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“…The expression of some LGICs by nonexcitable cells is suggestive of additional functions. By convention, the LGICs comprise the excitatory, cationselective, nicotinic acetylcholine [144,659], 5-HT3 [56,1042], ionotropic glutamate [588,997] and P2X receptors [436,946] and the inhibitory, anion-selective, GABAA [76,738] and glycine receptors [603,1116]. The nicotinic acetylcholine, 5-HT3, GABAA and glycine receptors (and an additional zinc-activated channel) are pentameric structures and are frequently referred to as the Cysloop receptors due to the presence of a defining loop of residues formed by a disulphide bond in the extracellular domain of their constituent subunits [662,975].…”

Section: Ligand-gated Ion Channelsmentioning

confidence: 99%

“…Ion channels → Ligand-gated ion channels → Ionotropic glutamate receptors Overview: The ionotropic glutamate receptors comprise members of the NMDA (N-methyl-D-aspartate), AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazoleproprionic acid) and kainate receptor classes, named originally according to their preferred, synthetic, agonist [226,588,997]. Receptor heterogeneity within each class arises from the homo-oligomeric, or hetero-oligomeric, assembly of distinct subunits into cation-selective tetramers.…”

Section: Ionotropic Glutamate Receptorsmentioning

confidence: 99%

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THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: Ion channels

Alexander

Mathie

Peters

et al. 2019

British J Pharmacology

295

248

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The Concise Guide to PHARMACOLOGY 2019/20 is the fourth in this series of biennial publications. The Concise Guide provides concise overviews of the key properties of nearly 1800 human drug targets with an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets and their ligands (http://www.guidetopharmacology.org/), which provides more detailed views of target and ligand properties. Although the Concise Guide represents approximately 400 pages, the material presented is substantially reduced compared to information and links presented on the website. It provides a permanent, citable, point‐in‐time record that will survive database updates. The full contents of this section can be found at http://onlinelibrary.wiley.com/doi/10.1111/bph.14749. Ion channels are one of the six major pharmacological targets into which the Guide is divided, with the others being: G protein‐coupled receptors, nuclear hormone receptors, catalytic receptors, enzymes and transporters. These are presented with nomenclature guidance and summary information on the best available pharmacological tools, alongside key references and suggestions for further reading. The landscape format of the Concise Guide is designed to facilitate comparison of related targets from material contemporary to mid‐2019, and supersedes data presented in the 2017/18, 2015/16 and 2013/14 Concise Guides and previous Guides to Receptors and Channels. It is produced in close conjunction with the International Union of Basic and Clinical Pharmacology Committee on Receptor Nomenclature and Drug Classification (NC‐IUPHAR), therefore, providing official IUPHAR classification and nomenclature for human drug targets, where appropriate.

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