THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: Ion channels

Abstract

The Concise Guide to PHARMACOLOGY 2019/20 is the fourth in this series of biennial publications. The Concise Guide provides concise overviews of the key properties of nearly 1800 human drug targets with an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets and their ligands (http://www.guidetopharmacology.org/), which provides more detailed views of target and ligand properties. Although the Concise Guide represents approximately 400 pages, the material presented is substantially reduced compared to information and links presented on the website. It provides a permanent, citable, point‐in‐time record that will survive database updates. The full contents of this section can be found at http://onlinelibrary.wiley.com/doi/10.1111/bph.14749. Ion channels are one of the six major pharmacological targets into which the Guide is divided, with the others being: G protein‐coupled receptors, nuclear hormone receptors, catalytic receptors, enzymes and transporters. These are presented with nomenclature guidance and summary information on the best available pharmacological tools, alongside key references and suggestions for further reading. The landscape format of the Concise Guide is designed to facilitate comparison of related targets from material contemporary to mid‐2019, and supersedes data presented in the 2017/18, 2015/16 and 2013/14 Concise Guides and previous Guides to Receptors and Channels. It is produced in close conjunction with the International Union of Basic and Clinical Pharmacology Committee on Receptor Nomenclature and Drug Classification (NC‐IUPHAR), therefore, providing official IUPHAR classification and nomenclature for human drug targets, where appropriate.

Fulditoxin, representing a new class of dimeric snake toxins, defines novel pharmacology at nicotinic ACh receptors

“…PHARMACOLOGY (Harding et al, 2018), and are permanently archived in the Concise Guide to PHARMACOLOGY 2019/20 (Alexander et al, 2019).…”

Novel neuroactive steroid with hypnotic and T‐type calcium channel blocking properties exerts effective analgesia in a rodent model of post‐surgical pain

“…In multigroup studies with parametric variables, post hoc tests (recommended by GraphPad prism, RRID:SCR_002798) were conducted only if F in ANOVA achieved the necessary level of statistical significance and there was no significant variance inhomogeneity. For in vitro experiments, data were analysed with paired or unpaired Stu-Nomenclature of targets and ligands Key protein targets and ligands in this article are hyperlinked to corresponding entries in http://www.guidetopharmacology.org, the common portal for data from the IUPHAR/BPS Guide to PHARMACOLOGY(Harding et al, 2018), and are permanently archived in the Concise Guide to PHARMACOLOGY 2019/20(Alexander et al, 2019). , and a loss of righting reflex (LORR) was monitored for each animal.…”

Icariside II, a phosphodiesterase 5 inhibitor, attenuates cerebral ischaemia/reperfusion injury by inhibiting glycogen synthase kinase‐3β‐mediated activation of autophagy

“…3-methylamphetamine (M9281), rapamycin (37094), SB216763 (S3442), and KT-5823 (K1388) were purchased from Sigma-Aldrich (St. Louis, MO, USA); antibodies were used against light-chain 3B (LC3B; Aviva Systems Biology Cat# ARP51335_P050, RRID:AB_ 2044956), Beclin 1 (Novus Cat# NB500-249B, RRID:AB_1216268), GSK-3β (Cell Signaling Technology Cat# 12456, RRID:AB_2636978), phospho-GSK-3β (Ser9; Cell Signaling Technology Cat# 14310, RRID: AB_2798445), phospho-GSK-3β (Tyr216; Abcam, Cat# 75745), SQSTM1/p62 (Cell Signaling Technology Cat# 5114, RRID: AB_10624872), APG5L/ATG5 (Abcam Cat# ab109490, RRID:AB_ 10861245), PDE 5A (LifeSpan Cat# LS-C42463-50, RRID: AB_1063421), anti-ATG7 (LifeSpan Cat# LS-C121392-50, RRID: AB_10800793), GAPDH (Proteintech Cat# 10494-1-AP, RRID: AB_2263076), and β-actin (Proteintech, Cat# 60008-1-Ig).2.22 | Nomenclature of targets and ligandsKey protein targets and ligands in this article are hyperlinked to corresponding entries in http://www.guidetopharmacology.org, the common portal for data from the IUPHAR/BPS Guide to PHARMA-COLOGY (RRID:SCR_013077;Harding et al, 2018), and are permanently archived in the Concise Guide to PHARMACOLOGY 2019/20(Alexander et al, 2019).…”