Charcot osteoarthropathy in conservative treatment: clinical and functional results

Vasconcelos, Jessica Castro de; Pagnano, Rodrigo Gonçalves; Resende, Mariângela Ribeiro; Moura, Arnaldo Vieira; Wittmann, Denise Engelbrecht Zantut; Parisi, Maria Cândida Ribeiro

doi:10.1186/1758-5996-7-s1-a17

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“…54 Other authors 55 reiterate these findings recommending adequate glycemic control for the prevention of foot complications and future amputations. 8,18,24,49,51 These factors were not significant in this cohort of patients that we reviewed. Offloading measures were used by some of the patients who sought care in the acute phase, constituting, in fact, the main treatment recommendation in this phase, which is fundamental to prevent future collapses and permanent deformities.…”

Section: Discussionmentioning

confidence: 85%

“…16,23,35,42,46-49 Poor glycemic control is identified as a risk for amputations 24,50 and CN in several epidemiological studies. 8,18,23,49,51 Elevated levels of A1c are strongly associated with chronic complications of DM. The mechanism is related to the high glycemic rates that stimulate the production of reactive oxygen species and, consequently, oxidative stress.…”

Section: Discussionmentioning

confidence: 99%

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Incidence and Predictive Factors for Amputations Derived From Charcot's Neuroarthropathy in Persons With Diabetes

Bandeira

Santos

Woo

et al. 2021

The International Journal of Lower Extremity Wounds

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Charcot's neuroarthropathy (CN) is the progressive destruction of the bones and joints of the feet, as a consequence of severe peripheral neuropathy, which predisposes patients to amputations. The purpose of this study was to measure the cumulative incidence of amputations resulting from CN and risk factors among amputated people with diabetes mellitus (DM). This was an epidemiological, observational, and retrospective study of 114 patients with DM who had an amputation involving the lower limbs. Data were collected from 2 specialized outpatient clinics between 2015 and 2019, including socio-demographic and clinical variables (cause of amputation: CN, peripheral arterial disease [PAD], infected ulcers, fracture, osteomyelitis, and others; body mass index [BMI]; 1 or 2 DM, time since DM diagnosis, insulin treatment, glycated hemoglobin; creatinine; smoking and drinking; systemic arterial hypertension, diabetic retinopathy, diabetic kidney disease, diabetic peripheral neuropathy, acute myocardial infarction, PAD, and stroke; characteristics of amputation [level and laterality], in addition to the specific variables related to CN [time of amputation in relation to the diagnosis of CN, diagnosis of CN in the acute phase, and treatment implemented in the acute phase]). We compared socio-demographic and clinical characteristics, including types of amputation, between patients with and without CN. Statistical analyses were performed using the 2 sample t-test or Wilcoxon–Mann–Whitney test, for quantitative variables, and the Pearson's χ2 test or Fisher's exact test for categorical variables. The investigation of the possible association of predictive factors for a CN amputation was carried out through logistic regression. The amputation caused by CN was present in 27 patients with a cumulative incidence of 23.7% in 5 years. There was a statistically significant association between BMI and the occurrence of CN (odds ratio: 1.083; 95% confidence interval: 1.001–1.173; P = .048); higher values of BMI were associated with a higher occurrence of amputations secondary from CN.

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