Characterizing the subjective, psychomotor, and physiological effects of oral oxycodone in non-drug-abusing volunteers

Zacny, James P.; Gutierrez, Sandra

doi:10.1007/s00213-003-1540-9

Cited by 110 publications

(103 citation statements)

References 37 publications

(44 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Some studies included questionnaires involving reinforcement data including drug effect, liking, and take again [6][7][8][9]. One study directly assessed breakpoint values of participants' desire for drug vs. money [10].…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Likeability and Abuse Liability of Commonly Prescribed Opioids

et al. 2012

View full text Add to dashboard Cite

Introduction Nonmedical use of prescription opioid analgesics is associated with epidemic levels of morbidity and mortality. There are several factors that affect the abuse liability of the various opioids, including likability or the pleasurable subjective effects. Due to rising public health concerns over escalating prescription opioid abuse, we sought to examine the literature about abuse liability with a specific focus on likability studies. Methods A search of EMBASE and MEDLINE databases identified articles that described the comparative likeability and/or abuse potential of hydrocodone and oxycodone relative to each other and/or of either one to morphine. After an assessment of study quality using the Oxford/Jadad scale, relevant details such as demographics, study design, and outcome measures were compiled into an evidence table.Results We identified nine studies that met inclusion criteria. All were double-blinded, randomized, placebocontrolled crossover studies and scored 5 out of 5 Jadad scale. There was no consistent clinically significant difference between abuse liability of morphine and hydrocodone. Oxycodone demonstrated high abuse liability on the basis of its high likability scores and a relative lack of negative subjective effects. Conclusion Oral oxycodone has an elevated abuse liability profile compared to oral morphine and hydrocodone.

show abstract

Section: Resultsmentioning

confidence: 99%

“…NIDA ratings and a paucity of negative ratings across the majority of studies assessed [7,9,10,12]. Oxycodone also demonstrated significantly increased reinforcing characteristics.…”

mentioning

confidence: 96%

Likeability and Abuse Liability of Commonly Prescribed Opioids

et al. 2012

View full text Add to dashboard Cite

show abstract

“…In the current study, complete pharmacodynamic characterizations of the time course of each medication were not performed. However, a previous study showed that the time course of oral oxycodone and morphine was similar (Zacny and Gutierrez, 2003). Because heroin is rapidly metabolized to morphine, the time course of effects for these two drugs is likely to be similar (see Comer et al, 1999;Jasinski and Preston, 1986).…”

Section: Discussionmentioning

confidence: 99%

Abuse Liability of Prescription Opioids Compared to Heroin in Morphine-Maintained Heroin Abusers

Comer

Sullivan

Whittington

et al. 2007

Neuropsychopharmacol

131

101

View full text Add to dashboard Cite

Abuse of prescription opioid medications has increased dramatically in the United States during the past decade, as indicated by a variety of epidemiological sources. However, few studies have systematically examined the relative reinforcing effects of commonly abused opioid medications. The current double-blind, placebo-controlled in-patient study was designed to compare the effects of intravenously delivered fentanyl (0, 0.0625, 0.125, 0.187, and 0.250 mg/70 kg), oxycodone (0, 6.25, 12.5, 25, and 50 mg/70 kg), morphine (0, 6.25, 12.5, 25, and 50 mg/70 kg), buprenorphine (0, 0.125, 0.5, 2, and 8 mg/70 kg), and heroin (0, 3.125, 6.25, 12.5, and 25 mg/70 kg) in morphinemaintained heroin abusers (N ¼ 8 completers maintained on 120 mg per day oral morphine in divided doses (30 mg q.i.d.)). All of the participants received all of the drugs tested; drugs and doses were administered in non-systematic order. All of the drugs produced statistically significant, dose-related increases in positive subjective ratings, such as 'I feel a good drug effect' and 'I like the drug.' In general, the order of potency in producing these effects, from most to least potent, was fentanyl4buprenorphineXheroin 4morphine ¼ oxycodone. In contrast, buprenorphine was the only drug that produced statistically significant increases in ratings of 'I feel a bad drug effect' and it was the only drug that was not self-administered above placebo levels at any dose tested. These data suggest that the abuse liability of buprenorphine in heroin-dependent individuals may be low, despite the fact that it produces increases in positive subjective ratings. The abuse liabilities of fentanyl, morphine, oxycodone, and heroin, however, appear to be similar under these experimental conditions.

show abstract

“…We used a dose of oxycodone that in past studies has produced subjective effects (Zacny and Gutierrez 2003Zacny and Lichtor 2008) and is in the upper range of therapeutically prescribed doses for relatively opioidnaïve patients, 10 mg. We tested two doses of ethanol (0.3 and 0.6 g/kg). Our primary hypothesis was that the two drugs taken together would produce a more positive profile than when either drug was taken alone and that the higher dose of ethanol combined with oxycodone would produce a greater magnitude of effect than the lower dose combined with the opioid.…”

Section: Introductionmentioning

confidence: 99%

Subjective, psychomotor, and physiological effects of oxycodone alone and in combination with ethanol in healthy volunteers

Zacny

Gutierrez

2011

Psychopharmacology

Self Cite

View full text Add to dashboard Cite

show abstract

Characterizing the subjective, psychomotor, and physiological effects of oral oxycodone in non-drug-abusing volunteers

Abstract: Oxycodone produced effects similar to those of other mu opioid agonists. Although oxycodone produced abuse liability-related subjective effects, it also produced unpleasant effects, a phenomenon we have observed in other opioid studies in non-drug-abusing volunteers.

Cited by 110 publications

References 37 publications

Likeability and Abuse Liability of Commonly Prescribed Opioids

Likeability and Abuse Liability of Commonly Prescribed Opioids

Abuse Liability of Prescription Opioids Compared to Heroin in Morphine-Maintained Heroin Abusers

Subjective, psychomotor, and physiological effects of oxycodone alone and in combination with ethanol in healthy volunteers

Contact Info

Product

Resources

About