Characterizing the metabolic effects of exogenous ketone supplementation – an alternative or adjuvant to the ketogenic diet

Poff, Angela M.; Kesl, Shannon; Koutnik, Andrew P.; Ward, N. I.; Ari, Csilla; DeBlasi, Janine M.; D’Agostino, Dominic P.

doi:10.1096/fasebj.31.1_supplement.970.7

Cited by 6 publications

(2 citation statements)

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“…First, decanoic acid increases the production of ketones (beta-hydroxybutyric acid, acetone, and acetoacetate). Ketones have various anti-inflammatory properties, including the inhibition of the NLRP3 inflammasome [33,34], reduction in the levels of cytosolic pro-inflammatory factors (IL-1β, IL-6, IFN-γ, MCP-1) [35], and inhibition of oxidative stress [36]. Inflammation is known to be integral to the development of CAD, initiating the early stages of atherosclerosis and continuing throughout the process.…”

Section: Discussionmentioning

confidence: 99%

Relationship between Dietary Decanoic Acid and Coronary Artery Disease: A Population-Based Cross-Sectional Study

Wu,

Yang,

et al. 2023

Nutrients

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Background: Coronary artery disease (CAD) is a cardiovascular disease with significant personal health and socioeconomic consequences. The biological functions of decanoic acid and the pathogenesis of CAD overlap considerably; however, studies exploring their relationship are limited. Methods: Data from 34,186 Americans from the National Health and Nutrition Examination Survey (NHANES) from 2003 to 2018 were analyzed. The relationship between dietary decanoic acid (DDA) and CAD prevalence was explored using weighted multivariate logistic regression models, generalized summation models, and fitted smoothing curves. Stratified analyses and interaction tests were conducted to explore the potential modifiers between them. Results: DDA was negatively associated with CAD prevalence, with each 1 g/d increase in the DDA being associated with a 21% reduction in CAD prevalence (odds ratio (OR) 0.79, 95% confidence interval (CI) 0.61–1.02). This relationship persisted after log10 and trinomial transformations, respectively. The OR after log10 transformation was 0.81 (95% CI 0.69–0.96), and the OR for tertile 3 compared with tertile 1 was 0.83 (95% CI 0.69–1.00). The subgroup analyses found this relationship to be significant among males and non-Hispanic white individuals, and there was a significant interaction (interaction p-values of 0.011 and 0.012, respectively). Conclusions: DDA was negatively associated with the prevalence of CAD, and both sex and race may modify this relationship.

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Section: Discussionmentioning

confidence: 99%

Relationship between Dietary Decanoic Acid and Coronary Artery Disease: A Population-Based Cross-Sectional Study

Wu,

Yang,

et al. 2023

Nutrients

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“…However, a study by Poff et al showed that the administration of ketone bodies alone was effective in reducing a number of pro-inflammatory cytokines, including IL-1β, IL-6, IFN-γ, MCP-1 and RANTES. This demonstrates that ketone bodies have important anti-inflammatory effects [90]. The publication by Youm et al confirms that BHB has the potential to alleviate inflammatory diseases mediated by the NLRP3 inflammasome.…”

Section: Anti-inflammatory Cardioprotective Potential Of the State Of...mentioning

confidence: 90%

The Ketogenic Diet and Cardiovascular Diseases

Dyńka,

Kowalcze,

Charuta

et al. 2023

Nutrients

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The most common and increasing causes of death worldwide are cardiovascular diseases (CVD). Taking into account the fact that diet is a key factor, it is worth exploring this aspect of CVD prevention and therapy. The aim of this article is to assess the potential of the ketogenic diet in the prevention and treatment of CVD. The article is a comprehensive, meticulous analysis of the literature in this area, taking into account the most recent studies currently available. The ketogenic diet has been shown to have a multifaceted effect on the prevention and treatment of CVD. Among other aspects, it has a beneficial effect on the blood lipid profile, even compared to other diets. It shows strong anti-inflammatory and cardioprotective potential, which is due, among other factors, to the anti-inflammatory properties of the state of ketosis, the elimination of simple sugars, the restriction of total carbohydrates and the supply of omega-3 fatty acids. In addition, ketone bodies provide “rescue fuel” for the diseased heart by affecting its metabolism. They also have a beneficial effect on the function of the vascular endothelium, including improving its function and inhibiting premature ageing. The ketogenic diet has a beneficial effect on blood pressure and other CVD risk factors through, among other aspects, weight loss. The evidence cited is often superior to that for standard diets, making it likely that the ketogenic diet shows advantages over other dietary models in the prevention and treatment of cardiovascular diseases. There is a legitimate need for further research in this area.

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Targeting the Warburg effect for cancer treatment: Ketogenic diets for management of glioma

Poff

Koutnik

Egan

et al. 2019

Seminars in Cancer Biology

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143

119

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Gliomas are a highly heterogeneous tumor, refractory to treatment and the most frequently diagnosed primary brain tumor. Although the current WHO grading system (2016) demonstrates promise towards identifying novel treatment modalities and better prediction of prognosis over time, to date, existing targeted and mono therapy approaches have failed to elicit a robust impact on disease progression and patient survival. It is possible that tumor heterogeneity as well as specifically targeted agents fail because redundant molecular pathways in the tumor make it refractory to such approaches. Additionally, the underlying metabolic pathology, which is significantly altered during neoplastic transformation and tumor progression, is unaccounted for. With several molecular and metabolic pathways implicated in the carcinogenesis of CNS tumors, including glioma, we postulate that a systemic, broad spectrum approach to produce robust targeting of relevant and multiple molecular and metabolic regulation of growth and survival pathways, critical to the modulation of hallmarks of carcinogenesis, without clinically limiting toxicity, may provide a more sustained impact on clinical outcomes compared to the modalities of treatment evaluated to date. The objective of this review is to examine the emerging hallmark of reprogramming energy metabolism of the tumor cells and the tumor microenvironment during carcinogenesis, and to provide a rationale for exploiting this hallmark and its biological capabilities as a target for secondary chemoprevention and treatment of glioma. This review will primarily focus on interventions to induce ketosis to target the glycolytic phenotype of many cancers, with specific application to secondary chemoprevention of low grade glioma- to halt the progression of lower grade tumors to more aggressive subtypes, as evidenced by reduction in validated intermediate endpoints of disease progression including clinical symptoms.

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Characterizing the metabolic effects of exogenous ketone supplementation – an alternative or adjuvant to the ketogenic diet

Cited by 6 publications

References 0 publications

Relationship between Dietary Decanoic Acid and Coronary Artery Disease: A Population-Based Cross-Sectional Study

Relationship between Dietary Decanoic Acid and Coronary Artery Disease: A Population-Based Cross-Sectional Study

The Ketogenic Diet and Cardiovascular Diseases

Targeting the Warburg effect for cancer treatment: Ketogenic diets for management of glioma

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