Characterizing Highly Cited Papers in Mass Cytometry through H-Classics

Zeo-Sánchez, Daniel E. Di; Sánchez-Núñez, Pablo; Stephens, Camilla; Lucena, M. Isabel

doi:10.3390/biology10020104

Cited by 7 publications

(4 citation statements)

References 66 publications

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“…Mass cytometry data can be analyzed by using SPADE Cluster Analysis, Principal Component Analysis and Boolean Gating (129,130).…”

Section: Mass Cytometrymentioning

confidence: 99%

Flow Cytometry: A Versatile and Powerful Tool for Drug Discovery and Development

Aru,

Yanikkaya Demirel

2024

Pharmedicine J.

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Flow cytometry, a pivotal tool in clinical and research labs since the discovery of cell markers in the mid-1970s, plays a crucial role across all phases of drug discovery. Modern flow cytometers can detect rare cell types relevant to disease pathogenesis, measure numerous parameters simultaneously, thus, offer versatility in drug screening. In drug discovery studies, flow cytometry contributes to the assessment of drug pharmacokinetics, pharmacodynamics and safety in animal models and clinical trials. It can also be used to monitor drug efficacy and identify biomarkers for diagnosis and prognosis. In essence, flow cytometry is a versatile, instrumental technique that supports drug discovery from target identification through to clinical development, limited only by the creativity of the researcher and the availability of fluorescent labels or specific size/scatter related findings. This review article focuses on the use of flow cytometry in drug discovery and drug development studies, summarizing not only conventional assays such as immunophenotyping, measurement of programmed cell death pathways and cell division to provide insights into drug effects and patient responses, but also novel approaches including mass cytometry, spectral cytometry, and droplet cytometry. Keywords: Flow cytometry, drug discovery, drug development, mass cytometry, spectral cytometry

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“…Mass cytometry data can be analyzed by using SPADE Cluster Analysis, Principal Component Analysis and Boolean Gating (129,130).…”

Section: Mass Cytometrymentioning

confidence: 99%

Flow Cytometry: A Versatile and Powerful Tool for Drug Discovery and Development

Aru,

Yanikkaya Demirel

2024

Pharmedicine J.

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“…In recent years, several innovative technologies capable of extracting large amounts of immunophenotypic information have emerged. Examples include high-dimensional and multiparametric fluorescent flow cytometry, single-cell messenger RNA (mRNA) sequencing, and mass cytometry [119].…”

Section: Future Perspectivesmentioning

confidence: 99%

Immunophenotyping to improve the mechanistic understanding of idiosyncratic drug-induced liver injury: clinical implications and future directions

et al. 2023

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The late event onset of a fraction of idiosyncratic drug-induced liver injury (DILI) cases and the link observed by genome-wide association studies (GWASs) of certain human leucocyte antigen (HLA) alleles with DILI due to specific drugs support the crucial role of the immune system (both innate and adaptive) in the pathogenesis of DILI. Recent advances in both flow and mass cytometry have allowed the profiling of all major immune cell types in a given sample. Therefore, determining the lymphocyte populations in samples from patients with DILI would facilitate the development of specific biomarkers for DILI diagnosis and prognosis. To date, a few studies have explored the immune landscape in DILI. In a recent study of leukocyte immunophenotyping using flow cytometry from the Spanish DILI Registry, an important role of adaptive immune response in DILI is suggested. DILI patients had significantly higher levels of T helper 1 (Th1) cells and activated helper and cytotoxic T cells than healthy controls. Furthermore, the increased expression of negative immune checkpoints and ligands in DILI patients could reflect a restoration of the immune homeostasis. Differences in the profile of cytokines in DILI patients from the Drug-Induced Liver Injury Network (DILIN) also suggest an involvement of both innate and adaptive immune systems in DILI development and prognosis. Moreover, several studies based on immunophenotyping of liver infiltrates showed a distinctive pattern of cellular infiltrates in patients with immune checkpoint inhibitors (ICIs)-DILI, with lower levels of plasma cells, CD20+ B cells and CD4+ T cells than in autoimmune hepatitis (AIH) patients. These pioneering studies highlight the importance of immunophenotyping for the mechanistic understanding of DILI. In this review, available data on immunophenotyping in DILI are gathered, and the potential clinical applications of cutting-edge, novel immunophenotyping techniques are discussed.

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“…Several studies have been carried out using R Package Bibliometrix. Some examples have been works done in the field of social research and data science [34], the Internet of Things (IoT) logistics [35], biology [36], or artificial intelligence research [37], among others. Table 2 describes the main results of the analysis: document type, document content, and author collaboration.…”

Section: Bibliometric Analysis Tool: Bibliometrix (R Package)mentioning

confidence: 99%

Tax Regulation on Blockchain and Cryptocurrency: The Implications for Open Innovation

Peláez-Repiso

Sánchez-Núñez

Calvente

2021

Journal of Open Innovation: Technology, Market, and Complexity

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Blockchain is a technology that will change the relationships between the different actors in society, individuals, companies and administration, in aspects as important as taxation, by implementing concepts such as Self-sovereign identity (SSI) and Smart Contracts; which support, for example, virtual currencies, that are not controlled by any state, financial institution or centralized company. Hence, the growing interest of researchers, investors, traders, marketers, enterprises, and administrations to know the scope of this new technology and its tax implications. The main objective of this work is to clarify the status of these studies, explore issues, methods, findings, and trends as well as to define their meaning within the current research scenario. To achieve these objectives, bibliometric analysis was carried out, retrieving 349 research papers, and analyzing 343 papers published between 2015–2019 based on the results of the Web of Science (WoS).

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Characterizing Highly Cited Papers in Mass Cytometry through H-Classics

Cited by 7 publications

References 66 publications

Flow Cytometry: A Versatile and Powerful Tool for Drug Discovery and Development

Flow Cytometry: A Versatile and Powerful Tool for Drug Discovery and Development

Immunophenotyping to improve the mechanistic understanding of idiosyncratic drug-induced liver injury: clinical implications and future directions

Tax Regulation on Blockchain and Cryptocurrency: The Implications for Open Innovation

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