Characterizations on the Stability and Release Properties of β-ionone Loaded Thermosensitive Liposomes (TSLs)

Abstract

Liposomes with phase transition temperatures, T, near pathogenic site temperature are potential chemoprophylactic delivery vehicles. We prepared and characterized the thermal properties of liposomes composed of 1,2-dipalmitoyl- sn-glycero-3-phosphocholine (DPPC) and hydrogenated soy phosphatidylcholine (HSPC) incorporating β-ionone with T at 42 °C. Liposomes with β-ionone/lipid ratio (w/w) of 1:20 and 1:8 had the necessary stability and released most of the β-ionone. The molecular architecture surrounding T was studied by fluorescent probes, Raman spectroscopy, and differential scanning calorimeter (DSC). β-Ionone was found to be preferentially located in the deep regions of the lipid bilayer (toward the long chain alkyl of the lipid) at moderate loading. The results showed that β-ionone encapsulated liposomes have a superior release at higher loading amount. Increasing β-ionone leads to disorder in the liquid crystalline state and accelerates the release rate. These studies provide information on the membrane structural properties of β-ionone loaded liposomes that guide rational bioactive molecular delivery systems design for health products.

Development of Oral Delivery Systems with Enhanced Antioxidant and Anticancer Activity: Coix Seed Oil and β-Carotene Coloaded Liposomes

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Stability and release performance of curcumin-loaded liposomes with varying content of hydrogenated phospholipids

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Palladium-Catalyzed Alkynylation of Enones with Alkynylsilanes via C–C Bond Activation

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