Characterization of the Treponema denticola Virulence Factor Dentilisin

Kikuchi, Yuichiro; Ishihara, Kazuyuki

doi:10.1007/978-1-0716-0939-2_17

Cited by 4 publications

(6 citation statements)

References 29 publications

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“…By interrupting or modulating the host's intercellular signaling pathways and degrading host cell-matrix proteins, dentilisin contributes to the progression of the disease. It is involved in nutrient uptake, coaggregation, activation of the complement system, escape strategy of the host immune response, protein degradation and cell invasion (Dashper et al, 2011;Kikuchi & Ishihara, 2021). It is already considered that the variation in activity between strains may have epidemiological value and can influence the disease, therefore, higher levels of dentilisin activity characterizes a more virulent strain (Miller et al, 2014).…”

Section: Virulence Factors and Tissue Penetration Of T Denticolamentioning

confidence: 99%

Review- The periodontal pathogen Treponema denticola: an atherosclerosis risk factor

Santos

Lima

Palma

et al. 2021

RSD

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Objective: Treponema denticola “T. denticola” is a pathogen associated with periodontal diseases that exhibits capacity for adherence, invasion, and colonization of host tissues, which allows alternating its location and damage in different sites of human body. This review aimed to discuss different studies that detected T. denticola in atherosclerotic plaques, demonstrating the importance of periodontal disease on the systemic health and the necessity of exploring the outcome of this colonization apart from the oral cavity. Methodology: Fifty-five studies were identified and gathered in this review according to the following topics: Periodontal disease, atherosclerosis and T. denticola. In vitro and in vivo studies published between 2002 and 2020 were searched on PubMed, raising relevant insights about the role of T. denticola and its association with the systemic disease, atherosclerosis, focusing on the bacterial tissue invasion and development of atherosclerosis. Results: After bibliographic review, it was possible to identify studies demonstrating the presence of T. denticola and other oral pathogens in cardiac or vascular tissues and in blood serum, as well, there is research in which other evidence of a relationship with atherosclerosis is shown. Conclusion: The invasion of periodontal pathogens and its toxins associated to the host’s immune and inflammatory response may contribute to the development of atherosclerosis.

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Section: Virulence Factors and Tissue Penetration Of T Denticolamentioning

confidence: 99%

Review- The periodontal pathogen Treponema denticola: an atherosclerosis risk factor

Santos

Lima

Palma

et al. 2021

RSD

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“…In fact, about (55) (56) , other risk factors were reported to be involved in cell invasion, bacterial co-aggregation, nutrient uptake, complement activation, evasion of the host immune response, inhibition of the hemostasis system (49,52) . Furthermore, the highly existence of Periopathogen within the blood circulation & the synergistic effects with other oral pathogens in cardiovascular tissues, these evidences can interpret the strong associations with atherosclerosis, so, they can conclude that the invasion of highly resistant, putative periodontal pathogens & their toxins associated to the host's immune mechanism & inflammatory response may contribute to the development & progression of cardiovascular atheromatous plaques & atherosclerosis, with diabetes mellitus as well improved in various recent correlated studies (10,57,58,70) .…”

Section: Resultsmentioning

confidence: 99%

Invasion of Diabetic and Atherosclerotic Vessels Patients with Periopathogen Spirochete Treponema denticola in Iraqi Population

AL-Nasrawi,

Abd Ali,

Aljarah

et al. 2021

Indian Journal of Forensic Medicine & Toxicology

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Both Periodontitis & Atherosclerosis of Cardiovascular system are chronic inflammatory disorders can be performed by invasion of their connective tissues with aerobic & anaerobic infectious bacteria & formation of polymicrobial biofilms. Microbial & metabolic plaques are considered to be the initiating factor for many infectious & metabolic diseases, invasion of an oral & systemic organs with various opportunistic pathogens have been reported in many populations. Several studies have been published Conventional & Real time PCR with 16S r RNA gene to improve the existence of the DNA molecules of the most invasive periodontics pathogens in atheromatous plaques of diabetic & cardiovascular blood vessels disease patients.In the present study, among 100 atherosclerotic & diabetic patients suffered from various degrees of ischemic heart disease, the DNA molecules of Treponema denticola was detected in (45/100)45% of atheromatous plaque samples significantly in male 28 /45 (62%) more than 17/45(38%) in female patients (p = 0.07) with no significant importance in cardiovascular & diabetic patients more than 50 years old 23/45(51%) which was approximate to 22/45(49%) in younger than 50 years old. As well as, T. denticola DNA molecules were significantly displayed in atheromatous plaques of type (1, 2) diabetic patients 35 /45 (78%) more than in non-diabetic group 10/45(22%) (p= 0.07) & T. denticola DNA molecules did not displayed in the controller group.In conclusion: the present cross sectional study demonstrated the invasion of atheromatous plaques of cardiovascular atherosclerotic vessels & diabetic patients with highly aggressive anaerobic periodontal spirochetes T. denticola, these results improve the existence of additional risk factor that interfere with the pathogenesis of periodontitis & genesis of cardiovascular atherosclerosis & may be correlated with the atherosclerosis & diabetes mellitus diseases patients in Iraqi population.

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“…T. denticola has been shown to adhere to fibroblasts and epithelial cells, as well as to extracellular matrix proteins present in periodontal tissues [46]. One of its virulence factors (dentilisin) enables invasion and destruction of dental tissues [15,47]. This protease complex is also involved in biofilm formation, degradation of host proteins, and evasion of the host's immune system [15].…”

Section: Bacteria That Are Abundant In the Oral Cavities Of Cats With...mentioning

confidence: 99%

“…Their oral microbiomes may also be enriched in Fusobacterium nucleatum [12] or Odoribacter compared with healthy cats [13]. T. denticola in particular has been associated with irreversible periodontal disease in companion animals [14,15]. Additionally, in dogs with severe periodontal disease, Methanobrevibacter oralis, P. canis, and Tannerella spp.…”

Section: Introductionmentioning

confidence: 99%

The Oral Microbiome across Oral Sites in Cats with Chronic Gingivostomatitis, Periodontal Disease, and Tooth Resorption Compared with Healthy Cats

Anderson,

Rojas,

Scarsella

et al. 2023

Animals

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Feline chronic gingivostomatitis (FCGS) is a chronic mucosal and gingival inflammatory disease in which pathogenesis remains unclear. Interactions between the host inflammatory process, the host immune response, and the oral microbiome are implicated in this pathogenesis. To begin to understand this disease and the impact of the microbiome to host inflammatory disease states, we collected sterile noninvasive plaque biofilm samples from ten distinct sites within the oral cavity in cats with stomatitis (n = 12), healthy cats (n = 9), and cats with tooth resorption or periodontitis (n = 11). Analysis of full-length 16S rRNA gene sequences indicated that the microbiomes of cats with FCGS presented marked dysbiosis at multiple oral sites. Additionally, microbiome beta diversity varied with oral condition, indicating that stomatitis, periodontitis, and/or tooth resorption influence the microbiome differently. Lastly, we found that the microbiomes of swabs taken from the oral cavity were comparable to those taken from plaque using endodontic paper points, validating this as another sampling method. Collectively, our work furthers our understanding of the dysbiosis and composition of bacteria in the oral microbiome in FCGS, with hopes of contributing to the prevention, diagnosis, and treatment of this challenging condition in felines.

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Characterization of the Treponema denticola Virulence Factor Dentilisin

Cited by 4 publications

References 29 publications

Review- The periodontal pathogen Treponema denticola: an atherosclerosis risk factor

Review- The periodontal pathogen Treponema denticola: an atherosclerosis risk factor

Invasion of Diabetic and Atherosclerotic Vessels Patients with Periopathogen Spirochete Treponema denticola in Iraqi Population

The Oral Microbiome across Oral Sites in Cats with Chronic Gingivostomatitis, Periodontal Disease, and Tooth Resorption Compared with Healthy Cats

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